Synaptic remodeling, synaptic growth and the storage of long-term memory in Aplysia.

[1]  E. Kandel,et al.  Nuclear Translocation of CAM-Associated Protein Activates Transcription for Long-Term Facilitation in Aplysia , 2007, Cell.

[2]  E. Kandel,et al.  Molecular Mechanisms of Memory Storage in Aplysia , 2006, The Biological Bulletin.

[3]  Yasunori Hayashi,et al.  Dendritic Spine Geometry: Functional Implication and Regulation , 2005, Neuron.

[4]  W. Gan,et al.  Development of Long-Term Dendritic Spine Stability in Diverse Regions of Cerebral Cortex , 2005, Neuron.

[5]  M. Segal Dendritic spines and long-term plasticity , 2005, Nature Reviews Neuroscience.

[6]  E. Kandel,et al.  Serotonin-Induced Regulation of the Actin Network for Learning-Related Synaptic Growth Requires Cdc42, N-WASP, and PAK in Aplysia Sensory Neurons , 2005, Neuron.

[7]  T. Bonhoeffer,et al.  Bidirectional Activity-Dependent Morphological Plasticity in Hippocampal Neurons , 2004, Neuron.

[8]  Mu-ming Poo,et al.  Shrinkage of Dendritic Spines Associated with Long-Term Depression of Hippocampal Synapses , 2004, Neuron.

[9]  E. Kandel,et al.  Transient expansion of synaptically connected dendritic spines upon induction of hippocampal long-term potentiation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[10]  J. Weiner,et al.  Cell Adhesion Molecules in Synapse Formation , 2004, The Journal of Neuroscience.

[11]  John H Byrne,et al.  Dissociation of morphological and physiological changes associated with long-term memory in aplysia. , 2004, Journal of neurophysiology.

[12]  E. Kandel,et al.  The Persistence of Long-Term Memory A Molecular Approach to Self-Sustaining Changes in Learning-Induced Synaptic Growth , 2004, Neuron.

[13]  G. Ellis‐Davies,et al.  Structural basis of long-term potentiation in single dendritic spines , 2004, Nature.

[14]  N. Ziv,et al.  Cellular and molecular mechanisms of presynaptic assembly , 2004, Nature Reviews Neuroscience.

[15]  E. Kandel,et al.  Role of Aplysia cell adhesion molecules during 5-HT-induced long-term functional and structural changes. , 2003, Learning & memory.

[16]  Joseph E LeDoux,et al.  Structural plasticity and memory , 2004, Nature Reviews Neuroscience.

[17]  R. Fitzsimonds,et al.  The Presynaptic Release Apparatus Is Functional in the Absence of Dendritic Contact and Highly Mobile within Isolated Axons , 2003, Neuron.

[18]  P. Scheiffele Cell-cell signaling during synapse formation in the CNS. , 2003, Annual review of neuroscience.

[19]  Mary Chen,et al.  Presynaptic Activation of Silent Synapses and Growth of New Synapses Contribute to Intermediate and Long-Term Facilitation in Aplysia , 2003, Neuron.

[20]  Vincenzo De Paola,et al.  AMPA receptors regulate dynamic equilibrium of presynaptic terminals in mature hippocampal networks , 2003, Nature Neuroscience.

[21]  Richard G M Morris,et al.  Introduction. Long-term potentiation and structure of the issue. , 2003, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[22]  N. Ziv,et al.  Unitary Assembly of Presynaptic Active Zones from Piccolo-Bassoon Transport Vesicles , 2003, Neuron.

[23]  T. A. Ryan,et al.  Actin has a molecular scaffolding, not propulsive, role in presynaptic function , 2003, Nature Neuroscience.

[24]  Mu-ming Poo,et al.  Signalling and crosstalk of Rho GTPases in mediating axon guidance , 2003, Nature Cell Biology.

[25]  J. Fiala,et al.  Polyribosomes Redistribute from Dendritic Shafts into Spines with Enlarged Synapses during LTP in Developing Rat Hippocampal Slices , 2002, Neuron.

[26]  John H Byrne,et al.  Localized Neuronal Outgrowth Induced by Long-Term Sensitization Training in Aplysia , 2002, The Journal of Neuroscience.

[27]  Stephen J. Smith,et al.  Stability and Plasticity of Developing Synapses in Hippocampal Neuronal Cultures , 2002, The Journal of Neuroscience.

[28]  D. Benson,et al.  Structural Remodeling of the Synapse in Response to Physiological Activity , 2002, Cell.

[29]  R. Malenka,et al.  AMPA receptor trafficking and synaptic plasticity. , 2002, Annual review of neuroscience.

[30]  Michael J. Sailor,et al.  Remodeling of Synaptic Actin Induced by Photoconductive Stimulation , 2001, Cell.

[31]  E. Kandel The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses , 2001, Science.

[32]  E. Kandel,et al.  Rapid Increase in Clusters of Presynaptic Proteins at Onset of Long-Lasting Potentiation , 2001, Science.

[33]  Thomas J. Carew,et al.  Molecular Mechanisms Underlying a Unique Intermediate Phase of Memory in Aplysia , 2001, Neuron.

[34]  D. Benson,et al.  Stages of Synapse Development Defined by Dependence on F-Actin , 2001, The Journal of Neuroscience.

[35]  P. Greengard,et al.  Synapsin Controls Both Reserve and Releasable Synaptic Vesicle Pools during Neuronal Activity and Short-Term Plasticity inAplysia , 2001, The Journal of Neuroscience.

[36]  T. A. Ryan,et al.  Calcium accelerates endocytosis of vSNAREs at hippocampal synapses , 2001, Nature Neuroscience.

[37]  Eckart D. Gundelfinger,et al.  Assembling the Presynaptic Active Zone A Characterization of an Active Zone Precursor Vesicle , 2001, Neuron.

[38]  R. Yuste,et al.  Morphological changes in dendritic spines associated with long-term synaptic plasticity. , 2001, Annual review of neuroscience.

[39]  L Shapiro,et al.  Making memories stick: cell-adhesion molecules in synaptic plasticity. , 2000, Trends in cell biology.

[40]  A. Matus,et al.  Actin-based plasticity in dendritic spines. , 2000, Science.

[41]  E. Kandel,et al.  A novel function for serotonin-mediated short-term facilitation in aplysia: conversion of a transient, cell-wide homosynaptic hebbian plasticity into a persistent, protein synthesis-independent synapse-specific enhancement. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[42]  Zhongna Sun,et al.  Presynaptic Morphological Changes Associated with Long-Term Synaptic Facilitation Are Triggered by Actin Polymerization at Preexisting Varicositis , 2000, The Journal of Neuroscience.

[43]  Noam E Ziv,et al.  Assembly of New Individual Excitatory Synapses Time Course and Temporal Order of Synaptic Molecule Recruitment , 2000, Neuron.

[44]  S. Halpain,et al.  Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[45]  Roberto Malinow,et al.  LTP mechanisms: from silence to four-lane traffic , 2000, Current Opinion in Neurobiology.

[46]  Susanne E. Ahmari,et al.  Assembly of presynaptic active zones from cytoplasmic transport packets , 2000, Nature Neuroscience.

[47]  Michael A Sutton,et al.  Parallel Molecular Pathways Mediate Expression of Distinct Forms of Intermediate-Term Facilitation at Tail Sensory–Motor Synapses in Aplysia , 2000, Neuron.

[48]  N. Toni,et al.  LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite , 1999, Nature.

[49]  E. Kandel,et al.  A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis , 1999, Cell.

[50]  F. Engert,et al.  Dendritic spine changes associated with hippocampal long-term synaptic plasticity , 1999, Nature.

[51]  K. Svoboda,et al.  Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity. , 1999, Science.

[52]  Eric R Kandel,et al.  CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation , 1998, Cell.

[53]  J. Byrne,et al.  Cellular Correlates of Long-Term Sensitization inAplysia , 1998, The Journal of Neuroscience.

[54]  Gero Miesenböck,et al.  Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins , 1998, Nature.

[55]  Zhongna Sun,et al.  Binding of Serotonin to Receptors at Multiple Sites Is Required for Structural Plasticity Accompanying Long-Term Facilitation ofAplysia Sensorimotor Synapses , 1998, The Journal of Neuroscience.

[56]  A. Hall,et al.  Rho GTPases and the actin cytoskeleton. , 1998, Science.

[57]  E. Kandel,et al.  Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage , 1997, Cell.

[58]  E. Kandel,et al.  Mutation in the Phosphorylation Sites of MAP Kinase Blocks Learning-Related Internalization of apCAM in Aplysia Sensory Neurons , 1997, Neuron.

[59]  Zhongna Sun,et al.  Pathway-Specific Synaptic Plasticity: Activity-Dependent Enhancement and Suppression of Long-Term Heterosynaptic Facilitation at Converging Inputs on a Single Target , 1997, The Journal of Neuroscience.

[60]  E. Kandel,et al.  Toward a molecular definition of long-term memory storage. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[61]  T. Carew,et al.  Dynamics of Induction and Expression of Long-Term Synaptic Facilitation in Aplysia , 1996, The Journal of Neuroscience.

[62]  R. Fields,et al.  Neural cell adhesion molecules in activity-dependent development and synaptic plasticity , 1996, Trends in Neurosciences.

[63]  Eric R. Kandel,et al.  Cell Adhesion Molecules, CREB, and the Formation of New Synaptic Connections , 1996, Neuron.

[64]  D. Muller,et al.  Induction of long-term potentiation is associated with major ultrastructural changes of activated synapses. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[65]  Y. Jan,et al.  Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines , 1996, Nature.

[66]  Eric R Kandel,et al.  A novel intermediate stage in the transition between short- and long-term facilitation in the sensory to motor neuron synapse of aplysia , 1995, Neuron.

[67]  E. Kandel,et al.  C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia , 1994, Cell.

[68]  E. Kandel,et al.  5-HT and cAMP induce the formation of coated pits and vesicles and increase the expression of clathrin light chain in sensory neurons of aplysia , 1993, Neuron.

[69]  E. R. Kandel,et al.  Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communication , 1993, Cell.

[70]  E. Kandel,et al.  Structural changes accompanying memory storage. , 1993, Annual review of physiology.

[71]  E. Kandel,et al.  Inhibitors of protein and RNA synthesis block structural changes that accompany long-term heterosynaptic plasticity in Aplysia , 1992, Neuron.

[72]  E R Kandel,et al.  Serotonin-mediated endocytosis of apCAM: an early step of learning-related synaptic growth in Aplysia. , 1992, Science.

[73]  E. Kandel,et al.  Modulation of an NCAM-related adhesion molecule with long-term synaptic plasticity in Aplysia. , 1992, Science.

[74]  L. Squire,et al.  The medial temporal lobe memory system , 1991, Science.

[75]  J. Byrne,et al.  cAMP induces long-term morphological changes in sensory neurons ofAplysia , 1991, Brain Research.

[76]  Daniel,et al.  Cognitive Neuroscience Analyses of Memory: A Historical Perspective , 1991, Journal of Cognitive Neuroscience.

[77]  S. Schacher,et al.  Neuron-specific membrane glycoproteins promoting neurite fasciculation in Aplysia californica , 1990, The Journal of cell biology.

[78]  E. Kandel,et al.  Target-dependent structural changes accompanying long-term synaptic facilitation in Aplysia neurons. , 1990, Science.

[79]  C. H. Bailey,et al.  Time course of structural changes at identified sensory neuron synapses during long-term sensitization in Aplysia , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[80]  E R Kandel,et al.  Inhibitor of protein synthesis blocks long-term behavioral sensitization in the isolated gill-withdrawal reflex of Aplysia. , 1989, Journal of neurobiology.

[81]  C. H. Bailey,et al.  The anatomy of a memory: convergence of results across a diversity of tests , 1988, Trends in Neurosciences.

[82]  C. H. Bailey,et al.  Long-term sensitization in Aplysia increases the number of presynaptic contacts onto the identified gill motor neuron L7. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[83]  C. H. Bailey,et al.  Morphological basis of short-term habituation in Aplysia , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[84]  C. H. Bailey,et al.  Long-term memory in Aplysia modulates the total number of varicosities of single identified sensory neurons. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[85]  E. Kandel,et al.  Serotonin produces long-term changes in the excitability of Aplysia sensory neurons in culture that depend on new protein synthesis , 1987, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[86]  J. Byrne,et al.  Long-term sensitization in Aplysia: biophysical correlates in tail sensory neurons. , 1987, Science.

[87]  E R Kandel,et al.  A critical period for macromolecular synthesis in long-term heterosynaptic facilitation in Aplysia. , 1986, Science.

[88]  E R Kandel,et al.  Additional component in the cellular mechanism of presynaptic facilitation contributes to behavioral dishabituation in Aplysia. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[89]  W N Frost,et al.  Monosynaptic connections made by the sensory neurons of the gill- and siphon-withdrawal reflex in Aplysia participate in the storage of long-term memory for sensitization. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[90]  C. H. Bailey,et al.  Morphological basis of long-term habituation and sensitization in Aplysia. , 1983, Science.

[91]  E. Kandel,et al.  Mechanism of calcium current modulation underlying presynaptic facilitation and behavioral sensitization in Aplysia. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[92]  E. Kandel,et al.  Ultrastructure of the synapses of sensory neurons that mediate the gill-withdrawal reflex inAplysia , 1979, Journal of neurocytology.

[93]  Martin Goldstein,et al.  How We Know , 1978 .

[94]  E R Kandel,et al.  Functioning of identified neurons and synapses in abdominal ganglion of Aplysia in absence of protein synthesis. , 1971, Journal of neurophysiology.

[95]  Irving Kupfermann,et al.  Neuronal Correlates of Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia , 1970, Science.

[96]  E R Kandel,et al.  Neuronal Mechanisms of Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia , 1970, Science.