Know-how of RNA interference and its applications in research and therapy.

[1]  Hiroyuki Miyoshi,et al.  Optimization of an siRNA‐expression system with an improved hairpin and its significant suppressive effects in mammalian cells , 2004, The journal of gene medicine.

[2]  Reuven Agami,et al.  A large-scale RNAi screen in human cells identifies new components of the p53 pathway , 2004, Nature.

[3]  Tyra G. Wolfsberg,et al.  Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[4]  A. Brand,et al.  Spreading silence with Sid , 2004, Genome Biology.

[5]  Ji-Joon Song,et al.  The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes , 2003, Nature Structural Biology.

[6]  F. Leenders,et al.  Inducible shRNA expression for application in a prostate cancer mouse model. , 2003, Nucleic acids research.

[7]  Yang Shi,et al.  Small RNA: can RNA interference be exploited for therapy? , 2003, The Lancet.

[8]  T. Du,et al.  Asymmetry in the Assembly of the RNAi Enzyme Complex , 2003, Cell.

[9]  S. Asano,et al.  Maxizymes and small hairpin-type RNAs that are driven by a tRNA promoter specifically cleave a chimeric gene associated with leukemia in vitro and in vivo. , 2003, Cancer research.

[10]  René Bernards,et al.  New tools for functional mammalian cancer genetics , 2003, Nature Reviews Cancer.

[11]  K. Taira,et al.  Control of siRNA expression utilizing Cre-loxP recombination system. , 2003, Nucleic acids research. Supplement.

[12]  I. Hariharan,et al.  Big things from a little RNA. , 2003, Trends in Cell Biology.

[13]  D. Marks,et al.  The small RNA profile during Drosophila melanogaster development. , 2003, Developmental cell.

[14]  V. Ambros,et al.  Role of MicroRNAs in Plant and Animal Development , 2003, Science.

[15]  N. Perrimon,et al.  Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. , 2003, Developmental biology.

[16]  V. Ambros.  MicroRNA Pathways in Flies and Worms Growth, Death, Fat, Stress, and Timing , 2003, Cell.

[17]  Mamoru Watanabe,et al.  Inhibition of intracellular hepatitis C virus replication by synthetic and vector‐derived small interfering RNAs , 2003, EMBO reports.

[18]  S. Ishii,et al.  Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter. , 2003, Genes & development.

[19]  David P. Bartel,et al.  MicroRNAs: At the Root of Plant Development?1 , 2003, Plant Physiology.

[20]  S. Kaul,et al.  Targeting mortalin using conventional and RNA‐helicase‐coupled hammerhead ribozymes , 2003, EMBO reports.

[21]  D. Dykxhoorn,et al.  Killing the messenger: short RNAs that silence gene expression , 2003, Nature Reviews Molecular Cell Biology.

[22]  V. Ambros,et al.  MicroRNAs and Other Tiny Endogenous RNAs in C. elegans , 2003, Current Biology.

[23]  S. Douc-Rasy,et al.  La séquestration cytoplasmique de la protéine p53 revisitée , 2003 .

[24]  C. Burge,et al.  The microRNAs of Caenorhabditis elegans. , 2003, Genes & development.

[25]  C. Burge,et al.  Vertebrate MicroRNA Genes , 2003, Science.

[26]  P. Rowley,et al.  Inhibition of telomerase activity in human cancer cells by RNA interference. , 2003, Molecular cancer therapeutics.

[27]  G. Ruvkun,et al.  A uniform system for microRNA annotation. , 2003, RNA.

[28]  Patrick J. Paddison,et al.  An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo , 2003, Nature Genetics.

[29]  Judy Lieberman,et al.  RNA interference targeting Fas protects mice from fulminant hepatitis , 2003, Nature Medicine.

[30]  Phillip A Sharp,et al.  siRNAs can function as miRNAs , 2003 .

[31]  T. Tuschl,et al.  New microRNAs from mouse and human. , 2003, RNA.

[32]  Edwards Allen,et al.  P1/HC-Pro, a viral suppressor of RNA silencing, interferes with Arabidopsis development and miRNA unction. , 2003, Developmental cell.

[33]  G. Hannon,et al.  Germline transmission of RNAi in mice , 2003, Nature Structural Biology.

[34]  Petr Svoboda,et al.  RNAi: mammalian oocytes do it without RNA-dependent RNA polymerase. , 2003, RNA.

[35]  K. Taira,et al.  Comparison of the suppressive effects of antisense oligonucleotides and siRNAs directed against the same targets in mammalian cells. , 2003, Antisense & nucleic acid drug development.

[36]  K. Taira,et al.  Stimulatory effect of an indirectly attached RNA helicase-recruiting sequence on the suppression of gene expression by antisense oligonucleotides. , 2003, Antisense & nucleic acid drug development.

[37]  Michaela Scherr,et al.  Gene silencing mediated by small interfering RNAs in mammalian cells. , 2003, Current medicinal chemistry.

[38]  Inder M Verma,et al.  A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[39]  K. Taira,et al.  Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells. , 2003, Nucleic acids research.

[40]  P. Jarvis,et al.  Chromatin Silencing: RNA in the Driving Seat , 2003, Current Biology.

[41]  D. Baltimore,et al.  Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5 , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[42]  J. Couzin.  Small RNAs Make Big Splash , 2002, Science.

[43]  K. Taira,et al.  Development and application of siRNA expression vector. , 2002, Nucleic acids research. Supplement.

[44]  K. Taira,et al.  Effects on RNA interference in gene expression (RNAi) in cultured mammalian cells of mismatches and the introduction of chemical modifications at the 3'-ends of siRNAs. , 2002, Antisense & nucleic acid drug development.

[45]  Haibin Xia,et al.  siRNA-mediated gene silencing in vitro and in vivo , 2002, Nature Biotechnology.

[46]  Henning Urlaub,et al.  Single-Stranded Antisense siRNAs Guide Target RNA Cleavage in RNAi , 2002, Cell.

[47]  G. Hutvagner,et al.  A microRNA in a Multiple-Turnover RNAi Enzyme Complex , 2002, Science.

[48]  J. Lieberman,et al.  siRNA-directed inhibition of HIV-1 infection , 2002, Nature Medicine.

[49]  W. Nelson,et al.  Methyl-CpG Binding Domain Protein 2 Represses Transcription from Hypermethylated π-Class Glutathione S-Transferase Gene Promoters in Hepatocellular Carcinoma Cells* , 2002, The Journal of Biological Chemistry.

[50]  Eric J Wagner,et al.  Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. , 2002, Molecular cell.

[51]  W. Earnshaw,et al.  Reverse genetics of essential genes in tissue-culture cells: 'dead cells talking'. , 2002, Trends in cell biology.

[52]  D. Engelke,et al.  Effective expression of small interfering RNA in human cells , 2002, Nature Biotechnology.

[53]  K. Taira,et al.  U6 promoter–driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells , 2002, Nature Biotechnology.

[54]  Ali Ehsani,et al.  Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells , 2002, Nature Biotechnology.

[55]  Stacy L DeRuiter,et al.  RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[56]  M. Mann,et al.  miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. , 2002, Genes & development.

[57]  E. Moss,et al.  MicroRNAs: Hidden in the Genome , 2002, Current Biology.

[58]  S. Elledge,et al.  Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. , 2002, Genes & development.

[59]  J. Downward,et al.  The Serine Protease Omi/HtrA2 Regulates Apoptosis by Binding XIAP through a Reaper-like Motif* , 2002, The Journal of Biological Chemistry.

[60]  V. Ambros.  microRNAs Tiny Regulators with Great Potential , 2001, Cell.

[61]  S. Barik,et al.  Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses , 2001, BMC Microbiology.

[62]  K. Taira,et al.  Discovery of functional genes in the post-genome era by novel RNA-protein hybrid ribozymes. , 2001, Nucleic acids research. Supplement.

[63]  G. Hannon,et al.  C . elegans involved in developmental timing in Dicer functions in RNA interference and in synthesis of small RNA , 2001 .

[64]  R. Schultz,et al.  RNAi in mouse oocytes and preimplantation embryos: effectiveness of hairpin dsRNA. , 2001, Biochemical and biophysical research communications.

[65]  E. Moss,et al.  RNA interference: It's a small RNA world , 2001, Current Biology.

[66]  B. Bass,et al.  A Role for the RNase III Enzyme DCR-1 in RNA Interference and Germ Line Development in Caenorhabditis elegans , 2001, Science.

[67]  T. Tuschl,et al.  Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells , 2001, Nature.

[68]  T. Tuschl,et al.  RNA Interference and Small Interfering RNAs , 2001, Chembiochem : a European journal of chemical biology.

[69]  D. Baulcombe,et al.  Size constraints for targeting post-transcriptional gene silencing and for RNA-directed methylation in Nicotiana benthamiana using a potato virus X vector. , 2001, The Plant journal : for cell and molecular biology.

[70]  A. Caudy,et al.  Role for a bidentate ribonuclease in the initiation step of RNA interference , 2001 .

[71]  Magdalena Zernicka-Goetz,et al.  Specific interference with gene function by double-stranded RNA in early mouse development , 2000, Nature Cell Biology.

[72]  L Misquitta,et al.  Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): a role for nautilus in embryonic somatic muscle formation. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[73]  L. Sperling,et al.  Homology-dependent gene silencing in Paramecium. , 1998, Molecular biology of the cell.

[74]  A. Fire,et al.  Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans , 1998, Nature.

[75]  K. Kemphues,et al.  par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed , 1995, Cell.

[76]  V. Ambros,et al.  The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 , 1993, Cell.

[77]  C. Napoli,et al.  Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans. , 1990, The Plant cell.

[78]  T. Megraw,et al.  RNAi in cultured Drosophila cells. , 2004, Methods in molecular biology.

[79]  B. Reinhart,et al.  A biochemical framework for RNA silencing in plants. , 2003, Genes & development.

[80]  Yang Shi,et al.  Mammalian RNAi for the masses. , 2003, Trends in genetics : TIG.

[81]  K. Taira,et al.  Expression of siRNA from a single transcript that includes multiple ribozymes in mammalian cells. , 2003, Oligonucleotides.

[82]  J. Lisziewicz,et al.  Gene Therapy Approaches to HIV Infection , 2002, American journal of pharmacogenomics : genomics-related research in drug development and clinical practice.

[83]  C. Rossé,et al.  The exocyst is a Ral effector complex , 2002, Nature Cell Biology.

[84]  T. Pélissier,et al.  A DNA target of 30 bp is sufficient for RNA-directed DNA methylation. , 2000, RNA.