The effects of amrinone and calcium chloride on pulmonary vasculature and biventricular function in ethchlorvynol‐induced lung injury in sheep

The effects of amrinone and CaCl2 on pulmonary vasculature and biventricular function in sheep with acute lung injury (ALI) were studied. Seven sheep were ventilated with a tidal volume of 10–12 ml.kg‐1 with end‐tidal C02 of 40 ± 5 mmHg (5.3 ± 0.7 kPa) after acute lung injury was induced with up to 30 mg kg‐1 of ethchlorvynol (ECV). Biventricular function and hemodynamic profiles were estimated with a rapid computerized thermodilution method and modified pulmonary artery catheters after acute lung injury, following a loading dose (1 mg kg‐1) and maintenance dose (5 μg kg‐1 min‐1) of amrinone and after a bolus dose of CaCl2 (20 mg kg‐1). ECV successfully induced acute lung damage in sheep, causing significant increases in pulmonary artery pressure (PAP) and pulmonary vascular resistance index (PVRI). Amrinone reversed the unfavorable changes induced by ECV, significantly reducing PAP, PVRI and left ventricular end‐diastolic volume (LVEDV). CaCl2, however, reversed the effect of amrinone and increased PAP, PVRI, and LVEDV but decreased left ventricular ejection fraction.

[1]  J. Holaday,et al.  Calcium administration increases the mortality of endotoxic shock in rats. , 1989, Critical care medicine.

[2]  P. Jebson,et al.  Swine model of early adult respiratory distress syndrome induced by intravenous ethchlorvynol. , 1989, Critical care medicine.

[3]  J. Holaday,et al.  Hypercalcemia attenuates blood pressure response to epinephrine. , 1988, The Journal of pharmacology and experimental therapeutics.

[4]  M. Nakatsuka,et al.  The Combined use of Noradrenaline, Amrinone and Nitroglycerin in the Management of Severe Low Cardiac Output after Coronary Artery Surgery , 1988, Anaesthesia and intensive care.

[5]  Goldstein Ra.  Clinical effects of intravenous amrinone in patients with congestive heart failure. , 1986 .

[6]  J. Reeves,et al.  Effects of amrinone and milrinone on calcium influx into the myocardium. , 1986, Circulation.

[7]  R. A. Goldstein.  Clinical effects of intravenous amrinone in patients with congestive heart failure. , 1986, Circulation.

[8]  N. Rawlings.  THE SHEEP AS AN EXPERIMENTAL ANIMAL. , 1984 .

[9]  H. Schaff,et al.  Hemodynamic effects of calcium chloride injection following cardiopulmonary bypass: response to bolus injection and continuous infusion. , 1984, The Annals of thoracic surgery.

[10]  J. Lock,et al.  Pulmonary Vascular Effects of Amrinone in Conscious Lambs , 1983, Pediatric Research.

[11]  W. Sibbald,et al.  Biventricular Function in the Adult Respiratory Distress Syndrome: Hemodynamic and Radionuclide Assessment, with Special Emphasis on Right Ventricular Function , 1983 .

[12]  W. Sibbald,et al.  Biventricular function in the adult respiratory distress syndrome. , 1983, Chest.

[13]  P. Barash,et al.  Measurement of ejection fraction by thermal dilution techniques. , 1983, The Journal of surgical research.

[14]  J. Downs,et al.  Ionized calcium concentration and cardiovascular function after cardiopulmonary bypass. , 1981, Archives of surgery.

[15]  W. Sibbald,et al.  Does the pulmonary capillary wedge pressure predict left ventricular preload in critically ill patients? , 1981, Critical Care Medicine.

[16]  J. Duff,et al.  Pulmonary hypertension in sepsis: measurement by the pulmonary arterial diastolic-pulmonary wedge pressure gradient and the influence of passive and active factors. , 1978, Chest.

[17]  F. Glauser,et al.  Pulmonary tissue concentrations of ethchlorvynol after intravenous injection. , 1977, The American review of respiratory disease.

[18]  J. W. Bennett.  Regional body surface area of sheep , 1973, The Journal of Agricultural Science.