A Comprehensive Review On Pelletization Technology: A Novel Strategy For Formulation Development

Pelletization technology is gaining very much attention in present times as it has provided a competent pathway for the oral drug delivery system manufacturing. Pellets offers many biopharmaceuticals as well as technological recompenses over the conventional dosage forms. Pellets offer required strength for dose which can be blended for the delivery of incompatible bioactive agents and helps in providing different release profiles. In this review we will be discussing the extensively used techniques of pelletization, extrusion and spheronization in detail with their methods and applications in the field of pharmacy as a competent pathway for the novel drug delivery systems.

[1]  J. Siepmann,et al.  Controlled drug release from Gelucire-based matrix pellets: experiment and theory. , 2006, International journal of pharmaceutics.

[2]  H. Petereit,et al.  Properties of enteric coated sodium valproate pellets. , 2003, International journal of pharmaceutics.

[3]  Qian Zhang,et al.  Preparation and in vitro/in vivo evaluation of sustained-release metformin hydrochloride pellets. , 2006, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[4]  B. Seshagiri,et al.  DESIGN AND EVALUATION OF ATOMOXETINE HCl PELLETS BY MUPS TECHNOLOGY , 2014 .

[5]  T. Mehta,et al.  A REVIEW ON ORAL OSMOTICALLY DRIVEN SYSTEMS , 2013 .

[6]  W. Smith,et al.  Tablet granulations composed of spherical-shaped particles. , 1972, Journal of pharmaceutical sciences.

[7]  F. Bertrand,et al.  Optimization and scale-up of a fluid bed tangential spray rotogranulation process. , 2007, International journal of pharmaceutics.

[8]  Ravindra Tiwari,et al.  INFLUENCE OF PROCESS AND FORMULATION VARIABLES ON PHYSICAL PROPERTIES OF THE PELLETS USING A 2 3 FACTORIAL DESIGN Research Article , 2011 .

[9]  FORMULATION AND EVALUATION OF FLOATING MICROPARTICLES OF METOPROLOL SUCCINATE Research Article , 2011 .

[10]  P. Chaudhari,et al.  Development and evaluation of a novel modified release pellet-based system for the delivery of desloratadine and pseudoephedrine hydrochloride , 2011 .

[11]  T. Higuchi,et al.  Solubility determination of barely aqueous-soluble organic solids. , 1979, Journal of pharmaceutical sciences.

[12]  G. Alderborn,et al.  Drying behaviour of two sets of microcrystalline cellulose pellets. , 2001, International journal of pharmaceutics.

[13]  Hardik P Patel.  FORMULATION AND EVALUATION OF CONTROLLED POROSITY OSMOTIC DRUG DELIVERY SYSTEM OF METOPROLOL SUCCINATE , 2012 .

[14]  M. Reddy,et al.  A REVIEW OF PELLETS AND PELLETIZATION PROCESS - A MULTIPARTICULATE DRUG DELIVERY SYSTEM , 2013 .