Retina Measuring the Effect of Pars Plana Vitrectomy on Vitreous Oxygenation Using Magnetic Resonance Imaging

METHODS. Patients due to undergo PPV for either macular hole or epiretinal membrane were recruited. MRI scanning was performed 1 week before and at least 3 months after PPV. MRI T1 mapping was performed using an inversion recovery–true fast imaging with steady-state precession (TrueFISP) sequence at several inversion times, from a single slice positioned through the center of both eyes in the axial oblique plane. Additional phantom data were measured in porcine vitreous, to define the relationships between T1 relaxation times and balanced salt solution (BSS), to simulate human vitreous and aqueous, respectively, for a suitable pO2 range (5–70 mm Hg). Pre-PPV pO2 was also measured intraoperatively using a polarographic oxygen probe.

[1]  Yi Zhang,et al.  Human vitreous: MR imaging of oxygen partial pressure. , 2013, Radiology.

[2]  Sveinn H Hardarson,et al.  Retinal oximetry in central retinal artery occlusion , 2013, Acta ophthalmologica.

[3]  John T. Thompson.  Vitreomacular adhesion and neovascular age-related macular degeneration. , 2012, Retina.

[4]  Einar Stefánsson,et al.  Retinal vessel oxygen saturation in healthy individuals. , 2012, Investigative ophthalmology & visual science.

[5]  Einar Stefánsson,et al.  Oxygen saturation in branch retinal vein occlusion , 2012, Acta ophthalmologica.

[6]  P. Kroll,et al.  Appearance of age‐related macular degeneration in vitrectomized and nonvitrectomized eyes: an intraindividual case study , 2012, Acta ophthalmologica.

[7]  M. Landers,et al.  DETERMINATION OF RETINAL AND VITREOUS TEMPERATURE IN VITRECTOMY , 2012, Retina.

[8]  Einar Stefánsson,et al.  Retinal oxygen saturation is altered in diabetic retinopathy , 2011, British Journal of Ophthalmology.

[9]  Chung-May Yang,et al.  Transient regression of choroidal neovascularization membrane after vitrectomy in age‐related macular degeneration with vitreomacular traction syndrome , 2011, Acta ophthalmologica.

[10]  P. Tofts,et al.  Determination of T 1-Dependence on Oxygenation in the Eye Using a Simple Phantom Model , 2011 .

[11]  Young-Hoon Park,et al.  Comparison of two probe designs for determining intraocular oxygen distribution , 2010, British Journal of Ophthalmology.

[12]  M. Abràmoff,et al.  Effects of vitrectomy on age-related macular degeneration. , 2010, Ophthalmology.

[13]  M. Shimura,et al.  VITRECTOMY FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION WITH VITREOUS HEMORRHAGE , 2010, Retina.

[14]  E. Stefánsson,et al.  Diffusion characteristics of vitreous humour and saline solution follow the Stokes Einstein equation , 2009, Graefe's Archive for Clinical and Experimental Ophthalmology.

[15]  T. Williamson,et al.  Measurement of PO2 during vitrectomy for central retinal vein occlusion, a pilot study , 2009, Graefe's Archive for Clinical and Experimental Ophthalmology.

[16]  J. Crowley,et al.  The gel state of the vitreous and ascorbate-dependent oxygen consumption: relationship to the etiology of nuclear cataracts. , 2009, Archives of ophthalmology.

[17]  P. Tofts,et al.  Movement-Artefact-Free Measurement of T 1 in the Human Eye to Determine Oxygenation of the Vitreous Humour , 2009 .

[18]  E. Stefánsson.  Physiology of vitreous surgery , 2009, Graefe's Archive for Clinical and Experimental Ophthalmology.

[19]  B. Berkowitz,et al.  Prognostic MRI biomarkers of treatment efficacy for retinopathy , 2008, NMR in biomedicine.

[20]  S. Mennel,et al.  Vitreomacular traction and exudative age‐related macular degeneration , 2008, Acta ophthalmologica.

[21]  Francesca Mojana,et al.  The role of abnormal vitreomacular adhesion in age-related macular degeneration: spectral optical coherence tomography and surgical results. , 2008, American journal of ophthalmology.

[22]  D. Laidlaw,et al.  Vitrectomy for diabetic macular oedema , 2008, Eye.

[23]  Nick C Fox,et al.  Imaging cadavers: Cold FLAIR and noninvasive brain thermometry using CSF diffusion , 2008, Magnetic resonance in medicine.

[24]  N. Yoshimura,et al.  ROLE OF POSTERIOR VITREOUS DETACHMENT INDUCED BY INTRAVITREAL TISSUE PLASMINOGEN ACTIVATOR IN MACULAR EDEMA WITH CENTRAL RETINAL VEIN OCCLUSION , 2007, Retina.

[25]  Akinori Uemura,et al.  LONG-TERM OUTCOMES OF VITRECTOMY WITH OR WITHOUT ARTERIOVENOUS SHEATHOTOMY IN BRANCH RETINAL VEIN OCCLUSION , 2007, Retina.

[26]  E. Stefánsson,et al.  The Stokes-Einstein equation and the physiological effects of vitreous surgery. , 2006, Acta ophthalmologica Scandinavica.

[27]  J. Larsson,et al.  Vitrectomy for non-ischaemic macular oedema in retinal vein occlusion. , 2006, Acta ophthalmologica Scandinavica.

[28]  Y. Shui,et al.  Lower intraocular oxygen tension in diabetic patients: possible contribution to decreased incidence of nuclear sclerotic cataract. , 2006, American journal of ophthalmology.

[29]  Y. Shui,et al.  Oxygen distribution in the rabbit eye and oxygen consumption by the lens. , 2006, Investigative ophthalmology & visual science.

[30]  Naoyuki Maeda,et al.  Intraocular oxygen tension in eyes with proliferative diabetic retinopathy with and without vitreous , 1996, Graefe's Archive for Clinical and Experimental Ophthalmology.

[31]  Greg Zaharchuk,et al.  Measurement of cerebrospinal fluid oxygen partial pressure in humans using MRI , 2005, Magnetic resonance in medicine.

[32]  Ying-Bo Shui,et al.  Vitrectomy surgery increases oxygen exposure to the lens: a possible mechanism for nuclear cataract formation. , 2005, American journal of ophthalmology.

[33]  M. Maier.  Quantitative MRI of the brain—measuring changes caused by disease , 2004 .

[34]  Penny A. Gowland,et al.  T1: The Longitudinal Relaxation Time , 2004 .

[35]  H. Edelhauser,et al.  Intraocular irrigating solutions: a comparison of Hartmann's lactated Ringer's solution, BSS and BSS Plus , 1995, Graefe's Archive for Clinical and Experimental Ophthalmology.

[36]  C. Pournaras,et al.  Management of branch retinal vein occlusion with vitrectomy and arteriovenous adventitial sheathotomy, the possible role of surgical posterior vitreous detachment , 2004, Graefe's Archive for Clinical and Experimental Ophthalmology.

[37]  E. Stefánsson,et al.  The therapeutic effects of retinal laser treatment and vitrectomy. A theory based on oxygen and vascular physiology. , 2001, Acta ophthalmologica Scandinavica.

[38]  P S Tofts,et al.  Measuring the human retinal oxygenation response to a hyperoxic challenge using MRI: Eliminating blinking artifacts and demonstrating proof of concept , 2001, Magnetic resonance in medicine.

[39]  T. Yasuhara,et al.  Pars plana vitrectomy for regression of choroidal neovascularization with age-related macular degeneration. , 2000, Acta ophthalmologica Scandinavica.

[40]  N. Blair,et al.  Ocular oxygen consumption during vitreoperfusion in the cat. , 2000, Transactions of the American Ophthalmological Society.

[41]  T. Hikichi,et al.  Role of the vitreous and macular edema in branch retinal vein occlusion. , 1997, Ophthalmic surgery and lasers.

[42]  T. Hikichi,et al.  ROLE OF THE VITREOUS IN CENTRAL RETINAL VEIN OCCLUSION , 1996, Nippon Ganka Gakkai zasshi.

[43]  C. A. Wilson,et al.  Transcorneal oxygenation of the preretinal vitreous. , 1994, Archives of ophthalmology.

[44]  M. Litt,et al.  Rheology of the vitreous body: Part 2. Viscoelasticity of bovine and porcine vitreous. , 1994, Biorheology.

[45]  John Cawley,et al.  The determination of , 1993 .

[46]  G. Buchsbaum,et al.  Rheology of the vitreous body. Part I: Viscoelasticity of human vitreous. , 1992, Biorheology.

[47]  E. Stefánsson,et al.  Vitrectomy prevents retinal hypoxia in branch retinal vein occlusion. , 1990, Investigative ophthalmology & visual science.

[48]  Y Honda,et al.  Comparative study of vitreous oxygen tension in human and rabbit eyes. , 1989, Investigative ophthalmology & visual science.

[49]  J D Gass,et al.  Idiopathic senile macular hole. Its early stages and pathogenesis. , 1988, Archives of ophthalmology.

[50]  D. Altman,et al.  STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT , 1986, The Lancet.

[51]  G. Blankenship,et al.  Long-term diabetic vitrectomy results. Report of 10 year follow-up. , 1985, Ophthalmology.

[52]  M. Maguire,et al.  THE EFFECT OF LENSECTOMY ON THE INCIDENCE OF IRIS NEOVASCULARIZATION AND NEOVASCULAR GLAUCOMA AFTER VITRECTOMY FOR DIABETIC RETINOPATHY , 1983, American journal of ophthalmology.

[53]  E. Stefánsson,et al.  VITRECTOMY, LENSECTOMY, AND OCULAR OXYGENATION , 1982, Retina.

[54]  M L Wolbarsht,et al.  Increased retinal oxygen supply following pan-retinal photocoagulation and vitrectomy and lensectomy. , 1981, Transactions of the American Ophthalmological Society.

[55]  J. Hindman,et al.  Relaxation processes in water. A study of the proton spin‐lattice relaxation time , 1973 .

[56]  B. Schwartz,et al.  Temperature gradients in the rabbit eye. , 1962, Investigative ophthalmology.