Xenotropic Viruses: Murine Leukemia Viruses Associated with NIH Swiss, NZB, and Other Mouse Strains

Murine leukemia virus activity is present in tissues from NIH Swiss and other mouse strains after cocultivation with nonvirus-yielding rat cells transformed by Harvey sarcoma virus. The resulting pseudotype sarcoma virus has the same type-specific coat as the virus previously isolated from New Zealand black (NZB) mice, and, like the NZB virus, it is unable to infect mouse cells. The results show that this NZB type virus is endogenous in other strains of mice and is xenotropic; that is, it grows only in cells foreign to the host. This is the first clear demonstration that NIH Swiss mice also carry indigenous infectious murine leukemia virus.

[1]  W. T. Lane,et al.  Prevalence of type-C particles in visceral tissues of embryonic and newborn mice. , 1973, Journal of the National Cancer Institute.

[2]  J. Stephenson,et al.  Independent segregation of loci for activation of biologically distinguishable RNA C-type viruses in mouse cells. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[3]  G. Todaro,et al.  Antigenic properties of endogenous type-C viruses from spontaneously transformed clones of BALB-3T3. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[4]  D. Livingston,et al.  Endogenous type C virus from a cat cell clone with properties distinct from previously described feline type C virus. , 1973, Virology.

[5]  R. Huebner,et al.  A type-C virus in human rhabdomyosarcoma cells after inoculation into NIH Swiss mice treated with antithymocyte serum. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[6]  D. Ablashi,et al.  Characterization of murine Rauscher leukemia virus propagated in human cells. , 1972, Journal of the National Cancer Institute.

[7]  J. Levy,et al.  Lack of requirement of murine leukemia virus for early steps in infection of mouse embryo cells by murine sarcoma virus. , 1971, Virology.

[8]  R. Huebner,et al.  IMMUNOLOGICAL TOLERANCE TO RNA TUMOR VIRUS GENOME EXPRESSIONS: SIGNIFICANCE OF TOLERANCE AND PRENATAL EXPRESSIONS IN EMBRYOGENESIS AND TUMORIGENESIS , 1971 .

[9]  J. Levy.  Demonstration of differences in murine sarcoma virus foci formed in mouse and rat cells under a soft agar overlay. , 1971, Journal of the National Cancer Institute.

[10]  S. Aaronson.  Common Genetic Alterations of RNA Tumour Viruses grown in Human Cells , 1971, Nature.

[11]  J. Hartley,et al.  Plaque assay techniques for murine leukemia viruses. , 1970, Virology.

[12]  T. Pincus,et al.  Demonstration of Biological Activity of a Murine Leukemia Virus of New Zealand Black Mice , 1970, Science.

[13]  W. T. Lane,et al.  Group-specific antigen expression during embryogenesis of the genome of the C-type RNA tumor virus: implications for ontogenesis and oncogenesis. , 1970, Proceedings of the National Academy of Sciences of the United States of America.

[14]  J. Levy,et al.  Murine Sarcoma Virus: The Question of Defectiveness , 1970, Science.

[15]  B. Wright,et al.  Infection of human embryonic cell cultures with the Rauscher murine leukemia virus. , 1969, Cancer research.

[16]  M. Pollard,et al.  Wide Distribution of Leukaemia Virus in Strains of Laboratory Mice , 1968, Nature.

[17]  E. Rosenblum,et al.  Persistent Infection of a Rat Kidney Cell Line with Rauscher Murine Leukemia Virus , 1966, Journal of bacteriology.

[18]  W. T. Lane,et al.  Rescue of the defective genome of Moloney sarcoma virus from a noninfectious hamster tumor and the production of pseudotype sarcoma viruses with various murine leukemia viruses. , 1966, Proceedings of the National Academy of Sciences of the United States of America.

[19]  J. Hartley,et al.  Production of altered cell foci in tissue culture by defective Moloney sarcoma virus particles. , 1966, Proceedings of the National Academy of Sciences of the United States of America.