Neuropsychiatric symptoms in mild cognitive impairment: differences by subtype and progression to dementia

Neuropsychiatric symptoms (NPS) are common in patients with mild cognitive impairment (MCI). Little is known, however, about how NPS vary by MCI subtype (i.e. amnestic, single domain non‐memory, and multiple domain). In addition, it is unclear whether NPS increase risk of progression to dementia. We investigated the distribution of NPS across MCI subtypes and determined whether NPS increase risk of progression to dementia.

[1]  E. Tangalos,et al.  De novo genesis of neuropsychiatric symptoms in Mild Cognitive Impairment (MCI) , 2004, International Psychogeriatrics.

[2]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[3]  Mental and Behavioral Disturbances in Dementia: Findings from the Cache County Study on Memory in Aging , 2000 .

[4]  Eric B. Larson,et al.  History of Depression as a Risk Factor for Alzheimer's Disease , 1995, Epidemiology.

[5]  B. Winblad,et al.  Predictors of progression from mild cognitive impairment to Alzheimer disease , 2007, Neurology.

[6]  Oscar L Lopez,et al.  Perspectives on depression, mild cognitive impairment, and cognitive decline. , 2006, Archives of general psychiatry.

[7]  P. Modrego,et al.  Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: a prospective cohort study. , 2004, Archives of neurology.

[8]  J. Cummings,et al.  Mild Cognitive Impairment is Associated With Characteristic Neuropsychiatric Symptoms , 2004, Alzheimer disease and associated disorders.

[9]  M. Trabucchi,et al.  Neuropsychiatric Symptoms in Amnestic and Nonamnestic Mild Cognitive Impairment , 2007, Dementia and Geriatric Cognitive Disorders.

[10]  D. Zaitchik,et al.  Psychiatric Symptomatology and Prodromal Alzheimer's Disease , 2003, Alzheimer disease and associated disorders.

[11]  P. Scheltens,et al.  Behavioral symptoms in mild cognitive impairment , 2004, Neurology.

[12]  E. Tangalos,et al.  CME Practice parameter: , 2022 .

[13]  J. Morris,et al.  The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assesment of Alzheimer's disease , 1989, Neurology.

[14]  A. Wallin,et al.  The Goteborg MCI study: mild cognitive impairment is a heterogeneous condition , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[15]  M. Mega,et al.  The Neuropsychiatric Inventory , 1994, Neurology.

[16]  C. Lyketsos,et al.  Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study. , 2002, JAMA.

[17]  R. Reitan.  Validity of the Trail Making Test as an Indicator of Organic Brain Damage , 1958 .

[18]  G A Chase,et al.  Psychiatric symptoms and nursing home placement of patients with Alzheimer's disease. , 1990, The American journal of psychiatry.

[19]  E. Tangalos,et al.  Mild Cognitive Impairment Clinical Characterization and Outcome , 1999 .

[20]  Brian R Ott,et al.  Apathy and executive dysfunction in mild cognitive impairment and Alzheimer disease. , 2003, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[21]  C. Jack,et al.  Patterns of atrophy differ among specific subtypes of mild cognitive impairment. , 2007, Archives of neurology.

[22]  Neuropsychiatric symptoms in the dementias , 2002 .

[23]  M. Roth,et al.  Blessed-Roth Dementia Scale (DS). , 1988, Psychopharmacology bulletin.

[24]  P. Rabins,et al.  Prevalence and correlates of behavioral and psychiatric symptoms in community‐dwelling elders with dementia or mild cognitive impairment: the Memory and Medical Care Study , 2003, International journal of geriatric psychiatry.

[25]  Kristine Yaffe,et al.  Patient and caregiver characteristics and nursing home placement in patients with dementia. , 2002, JAMA.

[26]  R. Petersen.  Mild cognitive impairment as a diagnostic entity , 2004, Journal of internal medicine.

[27]  R. Mayeux,et al.  Depressed mood and the incidence of Alzheimer's disease in the elderly living in the community. , 1996, Archives of general psychiatry.

[28]  M. Albert,et al.  The course of psychopathologic features in mild to moderate Alzheimer disease. , 1997, Archives of general psychiatry.

[29]  P. Werner,et al.  Anxiety disorder and accompanying subjective memory loss in the elderly as a predictor of future cognitive decline , 2003, International journal of geriatric psychiatry.