Conjugation of wildtype and hypoallergenic mugwort allergen Art v 1 to flagellin induces IL-10-DC and suppresses allergen-specific TH2-responses in vivo

[1]  A. Bathke,et al.  Cross‐sectional study on allergic sensitization of Austrian adolescents using molecule‐based IgE profiling , 2017, Allergy.

[2]  P. Demoly,et al.  The European Survey on Adverse Systemic Reactions in Allergen Immunotherapy (EASSI): A paediatric assessment , 2017, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[3]  A. Wan,et al.  Targeting Warburg Effect in Cancers with PEGylated Glucose , 2016, Advanced healthcare materials.

[4]  M. Karas,et al.  Quality Control of Biomedicinal Allergen Products – Highly Complex Isoallergen Composition Challenges Standard MS Database Search and Requires Manual Data Analyses , 2015, PloS one.

[5]  Z. Pan,et al.  An avian influenza A (H7N9) virus vaccine candidate based on the fusion protein of hemagglutinin globular head and Salmonella typhimurium flagellin , 2015, BMC Biotechnology.

[6]  W. Bao,et al.  mTORC1 Regulates Flagellin-Induced Inflammatory Response in Macrophages , 2015, PloS one.

[7]  M. Zhong,et al.  Flagellin-PAc Fusion Protein Inhibits Progression of Established Caries , 2015, Journal of dental research.

[8]  N. Ravin,et al.  Protection against Multiple Influenza A Virus Strains Induced by Candidate Recombinant Vaccine Based on Heterologous M2e Peptides Linked to Flagellin , 2015, PloS one.

[9]  S. Kim,et al.  Tetanus toxin fragment C fused to flagellin makes a potent mucosal vaccine , 2015, Clinical and experimental vaccine research.

[10]  C. Akdis,et al.  Novel immunotherapy vaccine development , 2014, Current opinion in allergy and clinical immunology.

[11]  M. Prausnitz,et al.  Microneedle delivery of an M2e-TLR5 ligand fusion protein to skin confers broadly cross-protective influenza immunity. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[12]  S. Akira,et al.  Prevention of Intestinal Allergy in Mice by rflaA:Ova Is Associated with Enforced Antigen Processing and TLR5-Dependent IL-10 Secretion by mDC , 2014, PloS one.

[13]  Validation of the first treatment-specific questionnaire for the assessment of patient satisfaction with allergen-specific immunotherapy in allergic patients: the ESPIA questionnaire. , 2013, The Journal of allergy and clinical immunology.

[14]  Y.M. Li,et al.  Flagellin-PAc Fusion Protein is a High-efficacy Anti-caries Mucosal Vaccine , 2012, Journal of dentistry research.

[15]  R. Vance,et al.  NAIPs: Building an innate immune barrier against bacterial pathogens , 2012, BioEssays : news and reviews in molecular, cellular and developmental biology.

[16]  C. Milne Paediatric Assessment , 2012, International Journal of Pharmaceutical Medicine.

[17]  S. Scheurer,et al.  A fusion protein of flagellin and ovalbumin suppresses the TH2 response and prevents murine intestinal allergy. , 2011, The Journal of allergy and clinical immunology.

[18]  Hao Xu,et al.  The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus , 2011, Nature.

[19]  J. Treanor,et al.  Induction of a potent immune response in the elderly using the TLR-5 agonist, flagellin, with a recombinant hemagglutinin influenza-flagellin fusion vaccine (VAX125, STF2.HA1 SI). , 2011, Vaccine.

[20]  J. Treanor,et al.  Safety and immunogenicity of a recombinant hemagglutinin influenza-flagellin fusion vaccine (VAX125) in healthy young adults. , 2010, Vaccine.

[21]  A. Gewirtz,et al.  TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin , 2010, European journal of immunology.

[22]  S. Scheurer,et al.  Fusion protein of TLR5-ligand and allergen potentiates activation and IL-10 secretion in murine myeloid DC. , 2010, Molecular immunology.

[23]  Marcius S Almeida,et al.  Mapping the interactions between a major pollen allergen and human IgE antibodies. , 2010, Structure.

[24]  S. Mizel,et al.  A recombinant flagellin-poxvirus fusion protein vaccine elicits complement-dependent protection against respiratory challenge with vaccinia virus in mice. , 2010, Viral immunology.

[25]  P. Briza,et al.  Targeting the cysteine-stabilized fold of Art v 1 for immunotherapy of Artemisia pollen allergy. , 2010, Molecular immunology.

[26]  Y. Suezer,et al.  CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signals. , 2010, Molecular immunology.

[27]  S. Mizel,et al.  Immunization of young African green monkeys with OprF epitope 8-OprI-type A- and B-flagellin fusion proteins promotes the production of protective antibodies against nonmucoid Pseudomonas aeruginosa. , 2009, Vaccine.

[28]  S. Akira,et al.  Immune responses of TLR5+ lamina propria dendritic cells in enterobacterial infection , 2009, Journal of Gastroenterology.

[29]  S. Vieths,et al.  Immune recognition of novel isoforms and domains of the mugwort pollen major allergen Art v 1. , 2009, Molecular immunology.

[30]  V. Leb,et al.  Characterization of HLA Class II/Peptide-TCR Interactions of the Immunodominant T Cell Epitope in Art v 1, the Major Mugwort Pollen Allergen1 , 2008, The Journal of Immunology.

[31]  Hiroshi Kiyono,et al.  Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5 , 2008, Nature Immunology.

[32]  P. Olliaro,et al.  Ensuring sustained ACT production and reliable artemisinin supply , 2007, Malaria Journal.

[33]  Y. Huang,et al.  A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity. , 2007, The Journal of infectious diseases.

[34]  Y. Huang,et al.  Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity. , 2007, Vaccine.

[35]  P. Briza,et al.  Pollen‐food syndromes associated with weed pollinosis: an update from the molecular point of view , 2006, Allergy.

[36]  S. Mizel,et al.  Flagellin Is an Effective Adjuvant for Immunization against Lethal Respiratory Challenge with Yersinia pestis , 2006, Infection and Immunity.

[37]  Young Ran Kim,et al.  A Bacterial Flagellin, Vibrio vulnificus FlaB, Has a Strong Mucosal Adjuvant Activity To Induce Protective Immunity , 2006, Infection and Immunity.

[38]  S. Michalek,et al.  Cellular Mechanisms of the Adjuvant Activity of the Flagellin Component FljB of Salmonella enterica Serovar Typhimurium To Potentiate Mucosal and Systemic Responses , 2005, Infection and Immunity.

[39]  B. Bohle,et al.  Antigen presentation of the immunodominant T-cell epitope of the major mugwort pollen allergen, Art v 1, is associated with the expression of HLA-DRB1 *01. , 2005, The Journal of allergy and clinical immunology.

[40]  M. D. de Veer,et al.  Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-κB and proinflammatory gene program activation in intestinal epithelial cells , 2004, BMC Microbiology.

[41]  R. Valenta,et al.  Vaccines for birch pollen allergy based on genetically engineered hypoallergenic derivatives of the major birch pollen allergen, Bet v 1 , 2004, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[42]  P. Briza,et al.  Art v 1, the major allergen of mugwort pollen, is a modular glycoprotein with a defensin‐like and a hydroxyproline‐rich domain , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[43]  Peter Kelemen,et al.  The T Cell Response to Art v 1, the Major Mugwort Pollen Allergen, Is Dominated by One Epitope1 , 2002, The Journal of Immunology.

[44]  R. Valenta The future of antigen-specific immunotherapy of allergy , 2002, Nature Reviews Immunology.

[45]  H. Behrendt,et al.  [Geographic and time trends of pollen count due to beeches, grass and mugwort (Artemisia) in Germany]. , 2001, Pneumologie.

[46]  Clement BordierO Phase Separation of Integral Membrane Proteins in Triton X-114 Solution , 2001 .

[47]  G. Papa,et al.  An epidemiological survey on the allergological importance of some emerging pollens in Italy. , 2000, Journal of investigational allergology & clinical immunology.

[48]  H. Towbin,et al.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[49]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.