CD24hiCD27+ B cells from patients with allergic asthma have impaired regulatory activity in response to lipopolysaccharide

Regulatory B cells have been identified that strongly reduce allergic and auto‐immune inflammation in experimental models by producing IL‐10. Recently, several human regulatory B‐cell subsets with an impaired function in auto‐immunity have been described, but there is no information on regulatory B cells in allergic asthma.

[1]  M. Fujimoto,et al.  B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells. , 2013, The Journal of allergy and clinical immunology.

[2]  G. Pershagen,et al.  Environmental bacteria and childhood asthma , 2012, Allergy.

[3]  P. Lampertico,et al.  IL-10–Producing Regulatory B Cells in the Pathogenesis of Chronic Hepatitis B Virus Infection , 2012, The Journal of Immunology.

[4]  A. Hyvärinen,et al.  Exposure to microbial agents in house dust and wheezing, atopic dermatitis and atopic sensitization in early childhood: a birth cohort study in rural areas , 2012, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[5]  C. Mauri,et al.  Immune regulatory function of B cells. , 2012, Annual review of immunology.

[6]  H. Smits.  B cells in allergic diseases: Bad or Better? , 2012, Autoimmunity.

[7]  D. Gray,et al.  Schistosomes Induce Regulatory Features in Human and Mouse CD1dhi B Cells: Inhibition of Allergic Inflammation by IL-10 and Regulatory T Cells , 2012, PloS one.

[8]  M. Yazdanbakhsh,et al.  Regulatory B-cell induction by helminths: implications for allergic disease. , 2011, The Journal of allergy and clinical immunology.

[9]  Shing-Hwa Liu,et al.  Mite Allergen Der-p2 Triggers Human B Lymphocyte Activation and Toll-Like Receptor-4 Induction , 2011, PloS one.

[10]  A. Hyvärinen,et al.  High Indoor Microbial Levels Are Associated with Reduced Th1 Cytokine Secretion Capacity in Infancy , 2011, International Archives of Allergy and Immunology.

[11]  R. Flavell,et al.  TLR-2–Activated B Cells Suppress Helicobacter-Induced Preneoplastic Gastric Immunopathology by Inducing T Regulatory-1 Cells , 2011, The Journal of Immunology.

[12]  E. S. St. Clair,et al.  Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. , 2011, Blood.

[13]  D. Kasper,et al.  Systemic toll‐like receptor ligands modify B‐cell responses in human inflammatory bowel disease , 2011, Inflammatory bowel diseases.

[14]  C. Loddenkemper,et al.  Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection. , 2010, Immunity.

[15]  C. Akdis,et al.  Update in the Mechanisms of Allergen-Specific Immunotheraphy , 2010, Allergy, asthma & immunology research.

[16]  D. Vercelli,et al.  Farm living: effects on childhood asthma and allergy , 2010, Nature Reviews Immunology.

[17]  C. Pucillo,et al.  Regulatory B cells: evidence, developmental origin and population diversity. , 2010, Molecular immunology.

[18]  Q. Hamid,et al.  Children with atopic histories exhibit impaired lipopolysaccharide‐induced Toll‐like receptor‐4 signalling in peripheral monocytes , 2010, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[19]  F. Farraye,et al.  Differential regulation of TLR4 expression in human B cells and monocytes. , 2010, Molecular immunology.

[20]  J. Sordillo,et al.  Multiple microbial exposures in the home may protect against asthma or allergy in childhood , 2010, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[21]  M. Kronenberg,et al.  Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model. , 2010, The Journal of allergy and clinical immunology.

[22]  Margarida Saraiva,et al.  The regulation of IL-10 production by immune cells , 2010, Nature Reviews Immunology.

[23]  D. Isenberg,et al.  CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. , 2010, Immunity.

[24]  T. Tedder,et al.  B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer , 2010, Annals of the New York Academy of Sciences.

[25]  D. Robinson.  Regulatory T cells and asthma , 2009, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[26]  T. Zuberbier,et al.  Allergen extract‐induced interleukin‐10 in human memory B cells inhibits immunoglobulin E production , 2009, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[27]  Hyunjin Shin,et al.  B cells from periodontal disease patients express surface Toll‐like receptor 4 , 2009, Journal of leukocyte biology.

[28]  D. Strachan,et al.  Asthma and allergic symptoms in relation to house dust endotoxin: Phase Two of the International Study on Asthma and Allergies in Childhood (ISAAC II) , 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[29]  J. Correale,et al.  Helminth infections associated with multiple sclerosis induce regulatory B cells , 2008, Annals of neurology.

[30]  H. Hammad,et al.  Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection. , 2007, The Journal of allergy and clinical immunology.

[31]  M. Duddy,et al.  Distinct Effector Cytokine Profiles of Memory and Naive Human B Cell Subsets and Implication in Multiple Sclerosis , 2007, The Journal of Immunology.

[32]  B. Brunekreef,et al.  Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children. , 2006, The Journal of allergy and clinical immunology.

[33]  D. Nowak,et al.  Microbial exposure of rural school children, as assessed by levels of N-acetyl-muramic acid in mattress dust, and its association with respiratory health. , 2004, The Journal of allergy and clinical immunology.

[34]  Alex Marotta,et al.  Bacterial DNA in house and farm barn dust. , 2003, The Journal of allergy and clinical immunology.

[35]  F. Sennhauser,et al.  Expression of CD14 and Toll-like receptor 2 in farmers' and nonfarmers' children , 2002, The Lancet.

[36]  T. Giese,et al.  Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides1 , 2002, The Journal of Immunology.

[37]  C. Karp,et al.  The germless theory of allergic disease: revisiting the hygiene hypothesis , 2001, Nature Reviews Immunology.

[38]  H. Ziegler-Heitbrock,et al.  Role of Stat3 in Lipopolysaccharide-Induced IL-10 Gene Expression1 , 2000, The Journal of Immunology.

[39]  M. Klinnert,et al.  Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma , 2000, The Lancet.

[40]  G. Guyatt,et al.  Development and validation of the Mini Asthma Quality of Life Questionnaire. , 1999, The European respiratory journal.

[41]  D. Strachan,et al.  Worldwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children: the International Study of Asthma and Allergies in Childhood (ISAAC) , 1997, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[42]  W. Solbach,et al.  B-cell outgrowth and ligand-specific production of IL-10 correlate with Th2 dominance in certain parasitic diseases. , 1996, Experimental parasitology.

[43]  J. Stockman.  Exposure to Environmental Microorganisms and Childhood Asthma , 2012 .

[44]  Jae Ho Lee,et al.  Characterisation of allergen-specific responses of IL-10-producing regulatory B cells (Br1) in Cow Milk Allergy. , 2010, Cellular immunology.

[45]  Hyunjin Shin,et al.  Inflammatory Disease Patients ChronicCytokine Production by B Cells from TLR Cross-Talk Specifically Regulates , 2009 .

[46]  R. Lauener,et al.  Expression of CD 14 and Toll-like receptor 2 In farmers ’ and non-farmers ’ childien , 2003 .

[47]  Lorian,et al.  ENVIRONMENTAL EXPOSURE TO ENDOTOXIN AND ITS RELATION TO ASTHMA IN SCHOOL-AGE CHILDREN , 2022 .