Kynurenic acid attenuates NMDA-induced pial arteriolar dilation in newborn pigs

[1]  D. Busija,et al.  Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets. , 2005, American journal of physiology. Heart and circulatory physiology.

[2]  S. Augood,et al.  Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease , 2004, Neurobiology of Disease.

[3]  W. Armstead.  NMDA and age dependent cerebral hemodynamics after traumatic brain injury. , 2004, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

[4]  A Schurr,et al.  Neuroprotection against ischemic/hypoxic brain damage: blockers of ionotropic glutamate receptor and voltage sensitive calcium channels. , 2004, Current drug targets.

[5]  D. Bleakman,et al.  Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro , 2004, Neuropharmacology.

[6]  P. Boksa.  Animal models of obstetric complications in relation to schizophrenia , 2004, Brain Research Reviews.

[7]  E. Zrenner,et al.  Kynurenic acid production in cultured bovine aortic endothelial cells. Homocysteine is a potent inhibitor , 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

[8]  A. Sarnowska,et al.  Endogenous level of kynurenic acid and activities of kynurenine aminotransferases following transient global ischemia in the gerbil hippocampus. , 2003, Polish journal of pharmacology.

[9]  W. Armstead.  Age dependent NMDA contribution to impaired hypotensive cerebral hemodynamics following brain injury. , 2002, Brain research. Developmental brain research.

[10]  R. Schwarcz,et al.  Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities , 2002, Journal of Pharmacology and Experimental Therapeutics.

[11]  M. Si,et al.  &agr;7-Nicotinic Acetylcholine Receptors on Cerebral Perivascular Sympathetic Nerves Mediate Choline-Induced Nitrergic Neurogenic Vasodilation , 2002, Circulation research.

[12]  C. Leffler,et al.  Role of carbon monoxide in glutamate receptor-induced dilation of newborn pig pial arterioles. , 2002, American journal of physiology. Heart and circulatory physiology.

[13]  D. Busija,et al.  N-methyl-D-aspartate-induced vasodilation is mediated by endothelium-independent nitric oxide release in piglets. , 2002, American journal of physiology. Heart and circulatory physiology.

[14]  R. Schwarcz,et al.  The Brain Metabolite Kynurenic Acid Inhibits α7 Nicotinic Receptor Activity and Increases Non-α7 Nicotinic Receptor Expression: Physiopathological Implications , 2001, The Journal of Neuroscience.

[15]  G. C. Palmer.  Neuroprotection by NMDA receptor antagonists in a variety of neuropathologies. , 2001, Current drug targets.

[16]  G. Lubec,et al.  Increased kynurenic acid in the brain after neonatal asphyxia. , 2001, Life sciences.

[17]  R. Schwarcz,et al.  Neonatal Asphyxia in Rats: Acute Effects on Cerebral Kynurenine Metabolism , 2001, Pediatric Research.

[18]  T. J. Lee,et al.  Presynaptic alpha7-nicotinic acetylcholine receptors mediate nicotine-induced nitric oxidergic neurogenic vasodilation in porcine basilar arteries. , 2001, The Journal of pharmacology and experimental therapeutics.

[19]  Akira Ishida,et al.  The Developing Nervous System: A Series of Review Articles: Neurobiology of Hypoxic-Ischemic Injury in the Developing Brain , 2001, Pediatric Research.

[20]  T. Stone.  Development and therapeutic potential of kynurenic acid and kynurenine derivatives for neuroprotection. , 2000, Trends in pharmacological sciences.

[21]  F. Moroni,et al.  Kynurenine Hydroxylase Inhibitors Reduce Ischemic Brain Damage: Studies with (m-Nitrobenzoyl)-Alanine (mNBA) and 3,4-Dimethoxy-[-N-4-(Nitrophenyl)Thiazol-2YL]-Benzenesulfonamide (Ro 61-8048) in Models of Focal or Global Brain Ischemia , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[22]  F. Moroni,et al.  Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites. , 1999, European journal of pharmacology.

[23]  S. Baratte,et al.  Temporal and spatial changes of quinolinic acid immunoreactivity in the gerbil hippocampus following transient cerebral ischemia. , 1998, Brain research. Molecular brain research.

[24]  H. Scharfman,et al.  Effects of central and peripheral administration of kynurenic acid on hippocampal evoked responses in vivo and in vitro , 1998, Neuroscience.

[25]  R. Beninger,et al.  Modulation of striatal quinolinate neurotoxicity by elevation of endogenous brain kynurenic acid , 1998, British journal of pharmacology.

[26]  D. Busija,et al.  Inhibitory effects of hypoxia and adenosine on N-methyl-d-aspartate-induced pial arteriolar dilation in piglets , 1998, Brain Research.

[27]  D. Busija,et al.  Cerebral Ischemia/Reperfusion Increases Endothelial Nitric Oxide Synthase Levels by An Indomethacin-Sensitive Mechanism , 1998, Journal of Cerebral Blood Flow and Metabolism.

[28]  K. Kawai,et al.  Species Heterogeneity Between Gerbils and Rats: Quinolinate Production by Microglia and Astrocytes and Accumulations in Response to Ischemic Brain Injury and Systemic Immune Activation , 1997, Journal of neurochemistry.

[29]  D. Busija,et al.  Kainate-induced cerebrovascular dilation is resistant to ischemia in piglets. , 1997, Stroke.

[30]  A. Fergus,et al.  Regulation of cerebral microvessels by glutamatergic mechanisms , 1997, Brain Research.

[31]  D. Busija,et al.  Differential effects of short-term hypoxia and hypercapnia on N-methyl-D-aspartate-induced cerebral vasodilatation in piglets. , 1996, Stroke.

[32]  W. Meng,et al.  Effects of ischemia on cerebrovascular responses to N-methyl-D-aspartate in piglets. , 1996, The American journal of physiology.

[33]  W. Meng,et al.  Glutamate-induced cerebral vasodilation is mediated by nitric oxide through N-methyl-D-aspartate receptors. , 1995, Stroke.

[34]  S. Markey,et al.  Pentafluorobenzylation method for quantification of acidic tryptophan metabolites using electron capture negative ion mass spectrometry. , 1995, Analytical chemistry.

[35]  D. Choi.  Calcium: still center-stage in hypoxic-ischemic neuronal death , 1995, Trends in Neurosciences.

[36]  K. Breese,et al.  Responses of Cerebral Arterioles to Kainate , 1994, Stroke.

[37]  N. Finer,et al.  Long-term follow-up of term neonates with perinatal asphyxia. , 1993, Clinics in perinatology.

[38]  R. Traystman,et al.  MK-801 does not prevent impaired cerebrovascular reactivity to CO2 during hypoglycemia in piglets. , 1993, The American journal of physiology.

[39]  K. Breese,et al.  Nitric oxide mediates vasodilatation in response to activation of N-methyl-D-aspartate receptors in brain. , 1993, Circulation research.

[40]  S. Markey,et al.  Mechanism of Delayed Increases in Kynurenine Pathway Metabolism in Damaged Brain Regions Following Transient Cerebral Ischemia , 1993, Journal of neurochemistry.

[41]  W. Armstead,et al.  Topical arachidonic acid restores pial arteriolar dilation to hypercapnia of postischemic newborn pig brain. , 1992, The American journal of physiology.

[42]  T. Stone.  Sensitivity of hippocampal neurones to kainic acid, and antagonism by kynurenate , 1990, British journal of pharmacology.

[43]  L. Ford.  Results of N-methyl-D-aspartate antagonists in perinatal cerebral asphyxia therapy. , 1990, Pediatric neurology.

[44]  M. Mayer,et al.  Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[45]  C. Leffler,et al.  Dilator effects of amino acid neurotransmitters on piglet pial arterioles. , 1989, The American journal of physiology.

[46]  E. Costa,et al.  Kynurenic acid inhibits the activation of kainic and N-methyl-d-aspartic acid-sensitive ionotropic receptors by a different mechanism , 1989, Neuropharmacology.

[47]  P. Andiné,et al.  The excitatory amino acid antagonist kynurenic acid administered after hypoxic-ischemia in neonatal rats offers neuroprotection , 1988, Neuroscience Letters.

[48]  R. Simon,et al.  Inhibition of excitatory neurotransmission with kynurenate reduces brain edema in neonatal anoxia , 1986, Neuroscience Letters.

[49]  R. Beninger,et al.  The neurotoxic actions of quinolinic acid in the central nervous system. , 1986, Canadian journal of physiology and pharmacology.

[50]  R. Green,et al.  Effects of Indomethacin upon Cerebral Hemodynamics of Newborn Pigs , 1985, Pediatric Research.

[51]  R. Schwarcz,et al.  Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid , 1984, Neuroscience Letters.

[52]  R. Schwarcz,et al.  Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain. , 1983, Science.

[53]  T. Stone,et al.  Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS. , 1981, European journal of pharmacology.

[54]  Oili Salonen,et al.  Fetal hypoxia and structural brain abnormalities in schizophrenic patients, their siblings, and controls. , 2002, Archives of general psychiatry.

[55]  R. Schwarcz,et al.  Perinatal kynurenine pathway metabolism in the normal and asphyctic rat brain , 2000, Amino Acids.

[56]  D. Busija,et al.  Effects of ischemia on cerebral arteriolar dilation to arterial hypoxia in piglets. , 1998, Stroke.

[57]  P. Andiné,et al.  Hypoxia-ischemia in the neonatal rat brain: histopathology after post-treatment with NMDA and non-NMDA receptor antagonists. , 1994, Biology of the neonate.

[58]  T N Raju,et al.  Some animal models for the study of perinatal asphyxia. , 1992, Biology of the neonate.

[59]  J. Goddard-finegold,et al.  Cerebrovascular regulation and neonatal brain injury. , 1991, Pediatric neurology.