Multi-level classification of emphysema in HRCT lung images

Emphysema is a common chronic respiratory disorder characterised by the destruction of lung tissue. It is a progressive disease where the early stages are characterised by a diffuse appearance of small air spaces, and later stages exhibit large air spaces called bullae. A bullous region is a sharply demarcated region of emphysema. In this paper, it is shown that an automated texture-based system based on co-training is capable of achieving multiple levels of emphysema extraction in high-resolution computed tomography (HRCT) images. Co-training is a semi-supervised technique used to improve classifiers that are trained with very few labelled examples using a large pool of unseen examples over two disjoint feature sets called views. It is also shown that examples labelled by experts can be incorporated within the system in an incremental manner. The results are also compared against “density mask”, currently a standard approach used for emphysema detection in medical image analysis and other computerized techniques used for classification of emphysema in the literature. The new system can classify diffuse regions of emphysema starting from a bullous setting. The classifiers built at different iterations also appear to show an interesting correlation with different levels of emphysema, which deserves more exploration.