A modality‐independent approach to spatial normalization of tomographic images of the human brain

A modality‐independent approch for interactive spatial normalization of tomographic images of the human brain is described and its performance evaluated. Spatial normalization is accomplished using a nine‐parameter affine transformation to interactively align and adjust the shape of a subject brain to the reference brain detailed in the 1988 atlas of Talairach et al. A user‐friendly software application was developed using the X‐windows Motif environment to guide the user through this process. This software supports data types from a wide variety of tomographic imagers and produces output in spatially concise formats.

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