Clinical translation of hyperpolarized 13C pyruvate and urea MRI for simultaneous metabolic and perfusion imaging

The combined hyperpolarized (HP) 13C pyruvate and urea MRI has provided a simultaneous assessment of glycolytic metabolism and tissue perfusion for improved cancer diagnosis and therapeutic evaluation in preclinical studies. This work aims to translate this dual‐probe HP imaging technique to clinical research.

[1]  M. Meng,et al.  Metabolic imaging with hyperpolarized 13C pyruvate magnetic resonance imaging in patients with renal tumors—Initial experience , 2021, Cancer.

[2]  E. Feuer,et al.  The Effect of Advances in Lung-Cancer Treatment on Population Mortality. , 2020, The New England journal of medicine.

[3]  I. Hsu,et al.  Simultaneous metabolic and perfusion imaging using hyperpolarized 13C MRI can evaluate early and dose-dependent responses to radiotherapy in a prostate cancer mouse model. , 2020, International journal of radiation oncology, biology, physics.

[4]  Shuyu Tang,et al.  A metabolite‐specific 3D stack‐of‐spiral bSSFP sequence for improved lactate imaging in hyperpolarized [1‐13C]pyruvate studies on a 3T clinical scanner , 2020, Magnetic resonance in medicine.

[5]  D. Harries,et al.  Properties of Aqueous Trehalose Mixtures: Glass Transition and Hydrogen Bonding , 2020, Journal of chemical theory and computation.

[6]  D. Welch,et al.  Defining the Hallmarks of Metastasis. , 2019, Cancer research.

[7]  John Kurhanewicz,et al.  Hyperpolarized 13C MRI: State of the Art and Future Directions. , 2019, Radiology.

[8]  J. Kurhanewicz,et al.  The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized 13C MRSI , 2019, Cancers.

[9]  Christoffer Laustsen,et al.  Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology , 2018, Neoplasia.

[10]  Shuyu Tang,et al.  Investigation of analysis methods for hyperpolarized 13C‐pyruvate metabolic MRI in prostate cancer patients , 2018, NMR in biomedicine.

[11]  Shuyu Tang,et al.  A regional bolus tracking and real‐time B1 calibration method for hyperpolarized 13C MRI , 2018, Magnetic resonance in medicine.

[12]  Matthew S. Adams,et al.  Assessing high‐intensity focused ultrasound treatment of prostate cancer with hyperpolarized 13C dual‐agent imaging of metabolism and perfusion , 2018, NMR in biomedicine.

[13]  M. Neeman,et al.  Placental physiology monitored by hyperpolarized dynamic 13C magnetic resonance , 2018, Proceedings of the National Academy of Sciences.

[14]  P. Larson,et al.  Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion. , 2017, Cancer research.

[15]  H. Stødkilde-Jørgensen,et al.  Diabetes induced renal urea transport alterations assessed with 3D hyperpolarized 13C,15N‐Urea , 2017, Magnetic resonance in medicine.

[16]  M. Paluch,et al.  Glass-Forming Tendency of Molecular Liquids and the Strength of the Intermolecular Attractions , 2016, Scientific Reports.

[17]  C. Laustsen,et al.  Renal ischemia and reperfusion assessment with three‐dimensional hyperpolarized 13C,15N2‐urea , 2016, Magnetic resonance in medicine.

[18]  Matthew D. Robson,et al.  Simultaneous assessment of cardiac metabolism and perfusion using copolarized [1‐13C]pyruvate and 13C‐urea , 2016, Magnetic resonance in medicine.

[19]  Christel A. S. Bergström,et al.  Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability , 2015, International journal of pharmaceutics.

[20]  P. Lambin,et al.  Multiparametric imaging of patient and tumour heterogeneity in non-small-cell lung cancer: quantification of tumour hypoxia, metabolism and perfusion , 2015, European Journal of Nuclear Medicine and Molecular Imaging.

[21]  Matthew D. Robson,et al.  Cardiac perfusion imaging using hyperpolarized 13c urea using flow sensitizing gradients , 2015, Magnetic resonance in medicine.

[22]  J. Kurhanewicz,et al.  Simultaneous multiagent hyperpolarized 13C perfusion imaging , 2014, Magnetic resonance in medicine.

[23]  James B. Mitchell,et al.  Magnetic resonance imaging of the tumor microenvironment in radiotherapy: perfusion, hypoxia, and metabolism. , 2014, Seminars in radiation oncology.

[24]  I. Apostolova,et al.  Combined measurement of tumor perfusion and glucose metabolism for improved tumor characterization in advanced cervical carcinoma , 2014, Strahlentherapie und Onkologie.

[25]  P. Larson,et al.  High Resolution $^{13}$C MRI With Hyperpolarized Urea: In Vivo $T_{2}$ Mapping and $^{15}$N Labeling Effects , 2014, IEEE Trans. Medical Imaging.

[26]  W van Elmpt,et al.  Characterization of tumor heterogeneity using dynamic contrast enhanced CT and FDG-PET in non-small cell lung cancer. , 2013, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[27]  P. Larson,et al.  Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate , 2013, Science Translational Medicine.

[28]  Sven Diederichs,et al.  The hallmarks of cancer , 2012, RNA biology.

[29]  P. Larson,et al.  Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea. , 2012, Magnetic resonance imaging.

[30]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[31]  P. Larson,et al.  Imaging of blood flow using hyperpolarized [13C]Urea in preclinical cancer models , 2011, Journal of magnetic resonance imaging : JMRI.

[32]  Pieter Leffers,et al.  Monitoring Response to Antiangiogenic Therapy in Non–Small Cell Lung Cancer Using Imaging Markers Derived from PET and Dynamic Contrast-Enhanced MRI , 2011, The Journal of Nuclear Medicine.

[33]  Bernard Van Eerdenbrugh,et al.  A classification system to assess the crystallization tendency of organic molecules from undercooled melts. , 2010, Journal of pharmaceutical sciences.

[34]  John Kurhanewicz,et al.  Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. , 2010, Journal of magnetic resonance.

[35]  D. Mankoff,et al.  Tumor Metabolism and Blood Flow as Assessed by Positron Emission Tomography Varies by Tumor Subtype in Locally Advanced Breast Cancer , 2010, Clinical Cancer Research.

[36]  C. Pellerin,et al.  Role of hydrogen bonding in the formation of glasses by small molecules: a triazine case study , 2009 .

[37]  Asit K Chakraborti,et al.  FTIR studies on differential intermolecular association in crystalline and amorphous states of structurally related non-steroidal anti-inflammatory drugs. , 2008, Molecular pharmaceutics.

[38]  Julie R. Gralow,et al.  Tumor metabolism and blood flow changes by positron emission tomography: relation to survival in patients treated with neoadjuvant chemotherapy for locally advanced breast cancer. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[39]  Robert B Livingston,et al.  Blood flow and metabolism in locally advanced breast cancer: relationship to response to therapy. , 2002, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[40]  John M. Pauly,et al.  Improved automatic off‐resonance correction without a field map in spiral imaging , 1997, Magnetic resonance in medicine.

[41]  R. Harbaugh,et al.  Administration of intravenous urea and normal saline for the treatment of hyponatremia in neurosurgical patients. , 1989, Journal of neurosurgery.

[42]  A. Levin,et al.  Treatment of increased intracranial pressure: a comparison of different hyperosmotic agents and the use of thiopental. , 1979, Neurosurgery.

[43]  H. Yuki,et al.  Methylene-hydantoin and Related Compounds. I. On the Reaction of Pyruvic Acid and Urea: The Synthesis of 5-Methylene-hydantoin , 1966 .

[44]  C. Keith.  INTRAVENOUS UREA IN GLAUCOMA* , 1961, The British journal of ophthalmology.

[45]  P. Settlage,et al.  Effect of urea on cerebrospinal fluid pressure in human subjects; preliminary report. , 1956, Journal of the American Medical Association.