MIT Open Access Articles Mechanics in medicine

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[1]  A. L. Marsden,et al.  Computation of residence time in the simulation of pulsatile ventricular assist devices , 2014 .

[2]  Yuri Bazilevs,et al.  Shape optimization of pulsatile ventricular assist devices using FSI to minimize thrombotic risk , 2014 .

[3]  Mauro Ferrari,et al.  Three phase flow dynamics in tumor growth , 2014 .

[4]  Ying Li,et al.  Multiscale modeling and uncertainty quantification in nanoparticle-mediated drug/gene delivery , 2014 .

[5]  R. Bashir,et al.  Creating Living Cellular Machines , 2014, Annals of Biomedical Engineering.

[6]  Huajian Gao,et al.  A universal law for cell uptake of one-dimensional nanomaterials. , 2014, Nano letters.

[7]  Yuri Bazilevs,et al.  Fluid–structure interaction simulation of pulsatile ventricular assist devices , 2013, Computational Mechanics.

[8]  Mauro Ferrari,et al.  Problems in (nano)medical mechanics , 2013 .

[9]  Mauro Ferrari,et al.  On Computational Modeling in Tumor Growth , 2013, Archives of Computational Methods in Engineering.

[10]  Ben Fabry,et al.  Cell and tissue mechanics in cell migration. , 2013, Experimental cell research.

[11]  Masayuki Ito,et al.  ‘Living’ PEGylation on gold nanoparticles to optimize cancer cell uptake by controlling targeting ligand and charge densities , 2013, Nanotechnology.

[12]  Haiping Fang,et al.  Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets. , 2013, Nature nanotechnology.

[13]  Huajian Gao,et al.  Graphene microsheets enter cells through spontaneous membrane penetration at edge asperities and corner sites , 2013, Proceedings of the National Academy of Sciences.

[14]  Jaehong Key,et al.  Engineering discoidal polymeric nanoconstructs with enhanced magneto-optical properties for tumor imaging. , 2013, Biomaterials.

[15]  Paolo Decuzzi,et al.  On the near-wall accumulation of injectable particles in the microcirculation: smaller is not better , 2013, Scientific Reports.

[16]  Majid Minary-Jolandan,et al.  Nanofountain probe electroporation (NFP-E) of single cells. , 2013, Nano letters.

[17]  Woon-Hong Yeo,et al.  Nanotip analysis for dielectrophoretic concentration of nanosized viral particles , 2013, Nanotechnology.

[18]  Hyunjae Lee,et al.  Engineering of functional, perfusable 3D microvascular networks on a chip. , 2013, Lab on a chip.

[19]  Mauro Ferrari,et al.  In silico vascular modeling for personalized nanoparticle delivery. , 2013, Nanomedicine.

[20]  Hyun-Boo Lee,et al.  Electrolyte-free Amperometric Immunosensor using a Dendritic Nanotip. , 2013, RSC advances.

[21]  Mandy B. Esch,et al.  Microfabricated mammalian organ systems and their integration into models of whole animals and humans. , 2013, Lab on a chip.

[22]  Yu-Hsiang Hsu,et al.  In vitro perfused human capillary networks. , 2013, Tissue engineering. Part C, Methods.

[23]  W. Yeo,et al.  Rapid extraction and preservation of genomic DNA from human samples , 2013, Analytical and Bioanalytical Chemistry.

[24]  Woon-Hong Yeo,et al.  Dielectrophoretic concentration of low-abundance nanoparticles using a nanostructured tip , 2012, Nanotechnology.

[25]  Dong-Pyo Kim,et al.  Droplet electroporation in microfluidics for efficient cell transformation with or without cell wall removal. , 2012, Lab on a chip.

[26]  Michael J. Thrall,et al.  Human Lung Cancer Cells Grown in an Ex Vivo 3D Lung Model Produce Matrix Metalloproteinases Not Produced in 2D Culture , 2012, PloS one.

[27]  Chang Lu,et al.  Release of intracellular proteins by electroporation with preserved cell viability. , 2012, Analytical chemistry.

[28]  Giuseppe Pascazio,et al.  The preferential targeting of the diseased microvasculature by disk-like particles. , 2012, Biomaterials.

[29]  Neelesh A. Patankar,et al.  The immersed molecular finite element method , 2012 .

[30]  Woon-Hong Yeo,et al.  Nanoscale sensor analysis using the immersed molecular electrokinetic finite element method. , 2012, Nanoscale.

[31]  Warren C W Chan,et al.  The effect of nanoparticle size, shape, and surface chemistry on biological systems. , 2012, Annual review of biomedical engineering.

[32]  Sanjiv S Gambhir,et al.  Family of enhanced photoacoustic imaging agents for high-sensitivity and multiplexing studies in living mice. , 2012, ACS nano.

[33]  Oliver Gaemperli,et al.  Non-invasive anatomic and functional imaging of vascular inflammation and unstable plaque. , 2012, European heart journal.

[34]  Huajian Gao,et al.  Surface-structure-regulated penetration of nanoparticles across a cell membrane. , 2012, Nanoscale.

[35]  Ying Zheng,et al.  In vitro microvessels for the study of angiogenesis and thrombosis , 2012, Proceedings of the National Academy of Sciences.

[36]  Mauro Ferrari,et al.  Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution. , 2012, Journal of controlled release : official journal of the Controlled Release Society.

[37]  David G Spiller,et al.  Quantitative measurement of single cell dynamics. , 2012, Current opinion in biotechnology.

[38]  Victor M. Calo,et al.  Mathematical modeling of coupled drug and drug-encapsulated nanoparticle transport in patient-specific coronary artery walls , 2012 .

[39]  I. Szleifer,et al.  Confinement induced lateral segregation of polymer coated nanospheres , 2012 .

[40]  Kristoffer G. van der Zee,et al.  Numerical simulation of a thermodynamically consistent four‐species tumor growth model , 2012, International journal for numerical methods in biomedical engineering.

[41]  Daniel A. Heller,et al.  Treating metastatic cancer with nanotechnology , 2011, Nature Reviews Cancer.

[42]  Douglas A. Lauffenburger,et al.  Polyfunctional responses by human T cells result from sequential release of cytokines , 2011, Proceedings of the National Academy of Sciences.

[43]  Dimitris Tousoulis,et al.  Vulnerable plaque and inflammation: potential clinical strategies. , 2011, Current pharmaceutical design.

[44]  Huajian Gao,et al.  Cell entry of one-dimensional nanomaterials occurs by tip recognition and rotation. , 2011, Nature nanotechnology.

[45]  Bo Yu,et al.  Nanochannel electroporation delivers precise amounts of biomolecules into living cells. , 2011, Nature nanotechnology.

[46]  Ou Chen,et al.  Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration. , 2011, Angewandte Chemie.

[47]  Huajian Gao,et al.  Probing mechanical principles of focal contacts in cell–matrix adhesion with a coupled stochastic–elastic modelling framework , 2011, Journal of The Royal Society Interface.

[48]  M. Ferrari,et al.  What does physics have to do with cancer? , 2011, Nature Reviews Cancer.

[49]  Lance L. Munn,et al.  Fluid forces control endothelial sprouting , 2011, Proceedings of the National Academy of Sciences.

[50]  Huajian Gao,et al.  Cellular uptake of elastic nanoparticles. , 2011, Physical review letters.

[51]  John Quackenbush,et al.  Why Is There a Lack of Consensus on Molecular Subgroups of Glioblastoma? Understanding the Nature of Biological and Statistical Variability in Glioblastoma Expression Data , 2011, PloS one.

[52]  Juan B. Blanco-Canosa,et al.  Cellular uptake and fate of PEGylated gold nanoparticles is dependent on both cell-penetration peptides and particle size. , 2011, ACS nano.

[53]  Akif Ündar,et al.  Mechanical Circulatory Support for End-Stage Heart Failure in Repaired and Palliated Congenital Heart Disease , 2011, Current cardiology reviews.

[54]  S. Lindström,et al.  Miniaturization of biological assays -- overview on microwell devices for single-cell analyses. , 2011, Biochimica et biophysica acta.

[55]  Brandon J. Tefft,et al.  Enhancing Endothelial Cell Retention on ePTFE Constructs by siRNA-Mediated SHP-1 Gene , 2011 .

[56]  Jinming Gao,et al.  Modeling particle shape-dependent dynamics in nanomedicine. , 2011, Journal of nanoscience and nanotechnology.

[57]  B. Snijder,et al.  Origins of regulated cell-to-cell variability , 2011, Nature Reviews Molecular Cell Biology.

[58]  Joseph M. DeSimone,et al.  Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles , 2011, Proceedings of the National Academy of Sciences.

[59]  Stephen R Quake,et al.  Whole-genome molecular haplotyping of single cells , 2011, Nature Biotechnology.

[60]  R. Jain,et al.  Delivering nanomedicine to solid tumors , 2010, Nature Reviews Clinical Oncology.

[61]  Samir Mitragotri,et al.  Polymer particle shape independently influences binding and internalization by macrophages. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[62]  Woon-Hong Yeo,et al.  Size-selective immunofluorescence of Mycobacterium tuberculosis cells by capillary- and viscous forces. , 2010, Lab on a chip.

[63]  S. Nie,et al.  A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands. , 2010, ACS nano.

[64]  Mauro Ferrari,et al.  Tailoring the degradation kinetics of mesoporous silicon structures through PEGylation. , 2010, Journal of biomedical materials research. Part A.

[65]  Huajian Gao,et al.  Soft Matrices Suppress Cooperative Behaviors among Receptor-Ligand Bonds in Cell Adhesion , 2010, PloS one.

[66]  Kai Yang,et al.  Computer simulation of the translocation of nanoparticles with different shapes across a lipid bilayer. , 2010, Nature nanotechnology.

[67]  Chang Lu,et al.  One-step extraction of subcellular proteins from eukaryotic cells. , 2010, Lab on a chip.

[68]  D. Ingber,et al.  Reconstituting Organ-Level Lung Functions on a Chip , 2010, Science.

[69]  David A. Rand,et al.  Measurement of single-cell dynamics , 2010, Nature.

[70]  Shuming Nie,et al.  Understanding and overcoming major barriers in cancer nanomedicine. , 2010, Nanomedicine.

[71]  Lani F. Wu,et al.  Cellular Heterogeneity: Do Differences Make a Difference? , 2010, Cell.

[72]  Huixin He,et al.  DNA and carbon nanotubes as medicine. , 2010, Advanced drug delivery reviews.

[73]  J. Gong,et al.  Label-free attomolar detection of proteins using integrated nanoelectronic and electrokinetic devices. , 2010, Small.

[74]  Mauro Ferrari,et al.  Frontiers in cancer nanomedicine: directing mass transport through biological barriers. , 2010, Trends in biotechnology.

[75]  Craig A. Poland,et al.  Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma , 2010, Particle and Fibre Toxicology.

[76]  Heinz-Peter Schlemmer,et al.  PET/MRI: Paving the Way for the Next Generation of Clinical Multimodality Imaging Applications , 2010, Journal of Nuclear Medicine.

[77]  Younan Xia,et al.  The effects of size, shape, and surface functional group of gold nanostructures on their adsorption and internalization by cells. , 2010, Small.

[78]  M Ferrari,et al.  Size and shape effects in the biodistribution of intravascularly injected particles. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[79]  Roger D. Kamm,et al.  Microfluidic Platforms for Studies of Angiogenesis, Cell Migration, and Cell–Cell Interactions , 2010, Annals of Biomedical Engineering.

[80]  Matthew H. M. Lim,et al.  Perfused multiwell plate for 3D liver tissue engineering. , 2010, Lab on a chip.

[81]  L Preziosi,et al.  An elasto-visco-plastic model of cell aggregates. , 2010, Journal of theoretical biology.

[82]  Daniel A. Fletcher,et al.  Cell mechanics and the cytoskeleton , 2010, Nature.

[83]  Sei-Young Lee,et al.  Shaping nano-/micro-particles for enhanced vascular interaction in laminar flows , 2009, Nanotechnology.

[84]  Huajian Gao,et al.  Lifetime and strength of periodic bond clusters between elastic media under inclined loading. , 2009, Biophysical journal.

[85]  Agnes B Kane,et al.  Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos? , 2009, Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology.

[86]  Mauro Ferrari,et al.  Design of bio-mimetic particles with enhanced vascular interaction. , 2009, Journal of biomechanics.

[87]  D. E. Discher,et al.  Matrix elasticity directs stem cell lineage — Soluble factors that limit osteogenesis , 2009 .

[88]  Warren C W Chan,et al.  Mediating tumor targeting efficiency of nanoparticles through design. , 2009, Nano letters.

[89]  Xiangrong Li,et al.  Nonlinear simulations of solid tumor growth using a mixture model: invasion and branching , 2009, Journal of mathematical biology.

[90]  Subra Suresh,et al.  Size‐Dependent Endocytosis of Nanoparticles , 2009, Advanced materials.

[91]  Huajian Gao,et al.  Size and shape effects on diffusion and absorption of colloidal particles near a partially absorbing sphere: implications for uptake of nanoparticles in animal cells. , 2008, Physical review. E, Statistical, nonlinear, and soft matter physics.

[92]  L. Hood,et al.  Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood , 2008, Nature Biotechnology.

[93]  Edward Chu,et al.  A history of cancer chemotherapy. , 2008, Cancer research.

[94]  Stephanie E. A. Gratton,et al.  The effect of particle design on cellular internalization pathways , 2008, Proceedings of the National Academy of Sciences.

[95]  Samir Mitragotri,et al.  Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers. , 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

[96]  Mathias Brust,et al.  Uptake and intracellular fate of surface-modified gold nanoparticles. , 2008, ACS nano.

[97]  M Ferrari,et al.  The effect of shape on the margination dynamics of non-neutrally buoyant particles in two-dimensional shear flows. , 2008, Journal of biomechanics.

[98]  Francesco Stellacci,et al.  Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles. , 2008, Nature materials.

[99]  M Ferrari,et al.  The receptor-mediated endocytosis of nonspherical particles. , 2008, Biophysical journal.

[100]  Mauro Ferrari,et al.  Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. , 2008, Nature nanotechnology.

[101]  Hongyu Zhou,et al.  A nano-combinatorial library strategy for the discovery of nanotubes with reduced protein-binding, cytotoxicity, and immune response. , 2008, Nano letters.

[102]  Wei Liu,et al.  Protein Binding by Functionalized Multiwalled Carbon Nanotubes Is Governed by the Surface Chemistry of Both Parties and the Nanotube Diameter , 2008 .

[103]  Arezou A Ghazani,et al.  Assessing the effect of surface chemistry on gold nanorod uptake, toxicity, and gene expression in mammalian cells. , 2008, Small.

[104]  Huajian Gao,et al.  Lifetime and strength of adhesive molecular bond clusters between elastic media. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[105]  J. Karp,et al.  Nanocarriers as an Emerging Platform for Cancer Therapy , 2022 .

[106]  Ji Guo,et al.  Nanofabricated particles for engineered drug therapies: a preliminary biodistribution study of PRINT nanoparticles. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[107]  Samir Mitragotri,et al.  Particle shape: a new design parameter for micro- and nanoscale drug delivery carriers. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[108]  Vicki Stone,et al.  An in vitro study of the potential of carbon nanotubes and nanofibres to induce inflammatory mediators and frustrated phagocytosis , 2007 .

[109]  S. Mitragotri,et al.  Making polymeric micro- and nanoparticles of complex shapes , 2007, Proceedings of the National Academy of Sciences.

[110]  Shuming Nie,et al.  Nanotechnology for targeted cancer therapy , 2007, Expert review of anticancer therapy.

[111]  Thomas J. R. Hughes,et al.  Patient-Specific Vascular NURBS Modeling for Isogeometric Analysis of Blood Flow , 2007, IMR.

[112]  Albert van den Berg,et al.  Single cells or large populations? , 2007, Lab on a chip.

[113]  D. Discher,et al.  Shape effects of filaments versus spherical particles in flow and drug delivery. , 2007, Nature nanotechnology.

[114]  Bo Huang,et al.  Counting Low-Copy Number Proteins in a Single Cell , 2007, Science.

[115]  Xiaogang Qu,et al.  Carboxyl-modified single-walled carbon nanotubes selectively induce human telomeric i-motif formation , 2006, Proceedings of the National Academy of Sciences.

[116]  Yaling Liu,et al.  Rheology of red blood cell aggregation by computer simulation , 2006, J. Comput. Phys..

[117]  Dino Di Carlo,et al.  Dynamic single-cell analysis for quantitative biology. , 2006, Analytical chemistry.

[118]  M Ferrari,et al.  The adhesive strength of non-spherical particles mediated by specific interactions. , 2006, Biomaterials.

[119]  Chad A Mirkin,et al.  A bio-barcode assay for on-chip attomolar-sensitivity protein detection. , 2006, Lab on a chip.

[120]  F. Dosio,et al.  Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential , 2006, International journal of nanomedicine.

[121]  S. Sen,et al.  Matrix Elasticity Directs Stem Cell Lineage Specification , 2006, Cell.

[122]  Wing Kam Liu,et al.  Dielectrophoretic assembly of nanowires. , 2006, The journal of physical chemistry. B.

[123]  Samir Mitragotri,et al.  Role of target geometry in phagocytosis. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[124]  Arezou A Ghazani,et al.  Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. , 2006, Nano letters.

[125]  David Farrell,et al.  Immersed finite element method and its applications to biological systems. , 2006, Computer methods in applied mechanics and engineering.

[126]  Tejal A Desai,et al.  Micromachined devices: the impact of controlled geometry from cell-targeting to bioavailability. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[127]  Huajian Gao,et al.  Mechanics of receptor-mediated endocytosis. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[128]  Joseph M DeSimone,et al.  Direct fabrication and harvesting of monodisperse, shape-specific nanobiomaterials. , 2005, Journal of the American Chemical Society.

[129]  Vladimir P Torchilin,et al.  Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo , 2005, Nature Medicine.

[130]  Robert Langer,et al.  Endothelialized microvasculature based on a biodegradable elastomer. , 2005, Tissue engineering.

[131]  Cass T. Miller,et al.  Thermodynamically constrained averaging theory approach for modeling flow and transport phenomena in porous medium systems: 1. Motivation and overview , 2005 .

[132]  M. Ferrari,et al.  A Theoretical Model for the Margination of Particles within Blood Vessels , 2005, Annals of Biomedical Engineering.

[133]  Tim Liedl,et al.  Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. , 2005, Nano letters.

[134]  Maurizio Prato,et al.  Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties. , 2005, Journal of the American Chemical Society.

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[138]  Marc Dellian,et al.  Neovascular targeting therapy: paclitaxel encapsulated in cationic liposomes improves antitumoral efficacy. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

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