Traffic-related air pollution is associated with atopy in children living in urban areas.

Traffic emissions are a major source of air pollution in Western industrialized countries. To investigate the association between traffic-related air pollution and parameters of atopy, we studied 317 children 9 years of age living near major roads in two urban areas and one suburban area of a city in West Germany. Atopic sensitization was analyzed by skin-prick testing and determination of allergen-specific serum immunoglobulin E. Parents recorded allergic symptoms in a symptom diary, and physicians assessed allergic diseases. Personal NO2 exposure and NO2 concentrations in front of each child's home were measured. Outdoor NO2 was a good predictor for traffic exposure but a poor predictor for NO2 exposure at the personal level. Atopy was found to be related to outdoor NO2 (odds ratio for the association between symptoms of allergic rhinitis and outdoor NO2 = 1.81; 95% confidence interval = 1.02-3.21) but not to personal NO2 (odds ratio for the association between symptoms of allergic rhinitis and personal NO2 = 0.99; 95% confidence interval = 0.55-1.79). When the analysis was restricted to urban areas, we found that hay fever, symptoms of allergic rhinitis, wheezing, sensitization against pollen, house dust mites or cats, and milk or eggs were associated with outdoor NO2. The results indicate that traffic-related air pollution leads to increased prevalence of atopic sensitizations, allergic symptoms, and diseases.

[1]  G. Pershagen,et al.  Air pollution involving nitrogen dioxide exposure and wheezing bronchitis in children. , 1995, International journal of epidemiology.

[2]  Y Ishiyama,et al.  Studies of prevalence of Japanese cedar pollinosis among the residents in a densely cultivated area. , 1987, Annals of allergy.

[3]  H. Skov,et al.  Front-door concentrations and personal exposures of Danish children to nitrogen dioxide. , 1997, Environmental health perspectives.

[4]  U Keil,et al.  Self-reported wheezing and allergic rhinitis in children and traffic density on street of residence. , 1994, Annals of epidemiology.

[5]  K. Tadokoro,et al.  Diesel-exhaust particulates inoculated by the intranasal route have an adjuvant activity for IgE production in mice. , 1987, The Journal of allergy and clinical immunology.

[6]  P. Burge,et al.  Effect of domestic concentrations of nitrogen dioxide on airway responses to inhaled allergen in asthmatic patients , 1994, The Lancet.

[7]  B. Brunekreef,et al.  Motor vehicle exhaust and chronic respiratory symptoms in children living near freeways. , 1997, Environmental research.

[8]  Bert Brunekreef,et al.  Air Pollution from Truck Traffic and Lung Function in Children Living near Motorways , 1997, Epidemiology.

[9]  A. Saxon,et al.  Enhanced nasal cytokine production in human beings after in vivo challenge with diesel exhaust particles. , 1996, The Journal of allergy and clinical immunology.

[10]  J. Ring,et al.  Air pollution and allergy: experimental studies on modulation of allergen release from pollen by air pollutants. , 1997, International archives of allergy and immunology.

[11]  R Urbanek,et al.  Traffic-related NO2 and the prevalence of asthma and respiratory symptoms in seven year olds. , 1997, The European respiratory journal.

[12]  R. Davies,et al.  Nitrogen dioxide increases eosinophil activation in the early-phase response to nasal allergen provocation. , 1995, International archives of allergy and immunology.

[13]  H. Nitta,et al.  Respiratory health associated with exposure to automobile exhaust. II. Personal NO2 exposure levels according to distance from the roadside. , 1997, Journal of exposure analysis and environmental epidemiology.

[14]  T. Sandström,et al.  The inflammatory effects of 2 ppm NO2 on the airways of healthy subjects. , 1997, American journal of respiratory and critical care medicine.

[15]  M. Herdman,et al.  Effect of nitrogen dioxide and sulphur dioxide on airway response of mild asthmatic patients to allergen inhalation , 1994, The Lancet.

[16]  U Keil,et al.  The Association between Self‐Reported Symptoms of Asthma and Allergic Rhinitis and Self‐Reported Traffic Density on Street of Residence in Adolescents , 1996, Epidemiology.

[17]  M Svartengren,et al.  Nitrogen dioxide exposure enhances asthmatic reaction to inhaled allergen in subjects with asthma. , 1997, American journal of respiratory and critical care medicine.

[18]  R. Davies,et al.  Effect of six-hour exposure to nitrogen dioxide on early-phase nasal response to allergen challenge in patients with a history of seasonal allergic rhinitis. , 1995, The Journal of allergy and clinical immunology.

[19]  D. Diat-Sanchez,et al.  The role of diesel exhaust particles and their associated polyaromatic hydrocarbons in the induction of allergic airway disease , 1997 .

[20]  T. Nicolai,et al.  Prevalence of asthma and atopy in two areas of West and East Germany. , 1994, American journal of respiratory and critical care medicine.

[21]  E Lebret,et al.  Chronic respiratory symptoms in children and adults living along streets with high traffic density. , 1996, Occupational and environmental medicine.

[22]  S. Hisamichi,et al.  Comparison of the health effects between indoor and outdoor air pollution in Northeastern Japan , 1991 .

[23]  H. Nitta,et al.  Respiratory health associated with exposure to automobile exhaust. I. Results of cross-sectional studies in 1979, 1982, and 1983. , 1993, Archives of environmental health.

[24]  M. Wjst,et al.  Road traffic and adverse effects on respiratory health in children. , 1993, BMJ.

[25]  R K Griffiths,et al.  Hospital admissions for asthma in preschool children: relationship to major roads in Birmingham, United Kingdom. , 1994, Archives of environmental health.

[26]  Schäfer,et al.  The influence of cultural and educational factors on the validity of symptom and diagnosis questions for atopic eczema , 1998, The British journal of dermatology.