Risk‐based versus universal PrEP delivery during pregnancy: a cluster randomized trial in Western Kenya from 2018 to 2019

Integrating pre‐exposure prophylaxis (PrEP) delivery for pregnant and postpartum women within maternal and child health (MCH) clinics is feasible and acceptable. It is unknown whether a risk‐guided model would facilitate appropriate PrEP use among MCH attendees better than universally offering PrEP.

[1]  I. Speizer,et al.  Stigma in the health clinic and implications for PrEP access and use by adolescent girls and young women: conflicting perspectives in South Africa , 2022, BMC Public Health.

[2]  J. Baeten,et al.  “PrEP Gives the Woman the Control”: Healthcare Worker Perspectives on Using pre-Exposure Prophylaxis (PrEP) During Pregnancy and Postpartum in Kenya , 2022, Journal of the International Association of Providers of AIDS Care.

[3]  Gabrielle E. O'Malley,et al.  Brief Report: “What Is This PrEP?”—Sources and Accuracy of HIV Pre-Exposure Prophylaxis (PrEP) Awareness Among Adolescent Girls and Young Women Attending Family Planning and Maternal Child Health Clinics in Western Kenya , 2021, Journal of acquired immune deficiency syndromes.

[4]  L. Myer,et al.  “I had Made the Decision, and No One was Going to Stop Me” —Facilitators of PrEP Adherence During Pregnancy and Postpartum in Cape Town, South Africa , 2021, AIDS and Behavior.

[5]  V. Frye,et al.  Women’s views on communication with health care providers about pre-exposure prophylaxis (PrEP) for HIV prevention , 2021, Culture, health & sexuality.

[6]  Gabrielle E. O'Malley,et al.  Influences on early discontinuation and persistence of daily oral PrEP use among Kenyan adolescent girls and young women: a qualitative evaluation from a PrEP implementation program. , 2020, Journal of acquired immune deficiency syndromes.

[7]  L. Myer,et al.  'I had made the decision, and no one was going to stop me': Facilitators of PrEP adherence during pregnancy and postpartum in Cape Town, South Africa , 2020, medRxiv.

[8]  J. Schneider,et al.  A taxonomy of pragmatic measures of HIV preexposure prophylaxis use. , 2020, AIDS.

[9]  B. Chi,et al.  Defining gaps in pre-exposure prophylaxis delivery for pregnant and post-partum women in high-burden settings using an implementation science framework. , 2020, The lancet. HIV.

[10]  J. Schneider,et al.  A taxonomy of pragmatic measures of HIV pre-exposure prophylaxis (PrEP) Use: application in a PrEP-using cohort in Chicago, IL. , 2020, AIDS.

[11]  J. Baeten,et al.  Challenges of discrepant HIV tests in pregnant women in the PrEP era - to treat or not to treat? , 2020, The Journal of infectious diseases.

[12]  B. Chi,et al.  Incident HIV among pregnant and breast-feeding women in sub-Saharan Africa: a systematic review and meta-analysis. , 2020, AIDS.

[13]  J. Baeten,et al.  Frequency and predictors of tenofovir-diphosphate detection among young Kenyan women in a real-world pre-exposure prophylaxis implementation program. , 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[14]  B. Chi,et al.  Incident HIV among pregnant and breastfeeding women in sub-Saharan Africa: a systematic review and meta-analysis. , 2020, AIDS (London).

[15]  B. Chi,et al.  Emerging evidence from a systematic review of safety of pre‐exposure prophylaxis for pregnant and postpartum women: where are we now and where are we heading? , 2020, Journal of the International AIDS Society.

[16]  J. Baeten,et al.  Pre-exposure prophylaxis uptake and early continuation among pregnant and post-partum women within maternal and child health clinics in Kenya: results from an implementation programme. , 2019, The lancet. HIV.

[17]  J. Baeten,et al.  Perinatal outcomes following maternal pre‐exposure prophylaxis (PrEP) use during pregnancy: results from a large PrEP implementation program in Kenya , 2019, Journal of the International AIDS Society.

[18]  J. Baeten,et al.  A field evaluation of point-of-care creatinine testing within a large PrEP implementation program in Western Kenya. , 2019, Journal of acquired immune deficiency syndromes.

[19]  Danya E Keene,et al.  Social Networks and Its Impact on Women's Awareness, Interest, and Uptake of HIV Pre-exposure Prophylaxis (PrEP): Implications for Women Experiencing Intimate Partner Violence , 2019, Journal of acquired immune deficiency syndromes.

[20]  Gabrielle E. O'Malley,et al.  PrEP Implementation for Mothers in Antenatal Care (PrIMA): study protocol of a cluster randomised trial , 2019, BMJ Open.

[21]  Grace John-Stewart,et al.  Brief Report: Integration of PrEP Services Into Routine Antenatal and Postnatal Care Experiences From an Implementation Program in Western Kenya , 2018, Journal of acquired immune deficiency syndromes.

[22]  J. Baeten,et al.  Increased Risk of HIV Acquisition Among Women Throughout Pregnancy and During the Postpartum Period: A Prospective Per-Coital-Act Analysis Among Women With HIV-Infected Partners , 2018, The Journal of infectious diseases.

[23]  Nicola Lancki,et al.  Which Patients in the Emergency Department Should Receive Preexposure Prophylaxis? Implementation of a Predictive Analytics Approach , 2018, AIDS patient care and STDs.

[24]  L. Myer,et al.  Delivering preexposure prophylaxis to pregnant and breastfeeding women in Sub-Saharan Africa: the implementation science frontier. , 2017, AIDS.

[25]  Jennifer A. Unger,et al.  A Risk Assessment Tool for Identifying Pregnant and Postpartum Women Who May Benefit From Preexposure Prophylaxis , 2016, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[26]  J. Baeten,et al.  Pre-exposure Prophylaxis Use by Breastfeeding HIV-Uninfected Women: A Prospective Short-Term Study of Antiretroviral Excretion in Breast Milk and Infant Absorption , 2016, PLoS medicine.

[27]  R. Grant,et al.  Effectiveness and safety of oral HIV preexposure prophylaxis for all populations , 2016, AIDS.

[28]  J. Baeten,et al.  Tenofovir-based oral preexposure prophylaxis prevents HIV infection among women , 2016, Current opinion in HIV and AIDS.

[29]  Alison L. Drake,et al.  HIV acquisition during pregnancy and postpartum is associated with genital infections and partnership characteristics , 2015, AIDS.

[30]  N. Shaffer,et al.  Impact of Maternal HIV Seroconversion during Pregnancy on Early Mother to Child Transmission of HIV (MTCT) Measured at 4-8 Weeks Postpartum in South Africa 2011-2012: A National Population-Based Evaluation , 2015, PloS one.

[31]  L. van Damme,et al.  Perception of HIV Risk and Adherence to a Daily, Investigational Pill for HIV Prevention in FEM-PrEP , 2014, Journal of acquired immune deficiency syndromes.

[32]  Alison L. Drake,et al.  Incident HIV during Pregnancy and Postpartum and Risk of Mother-to-Child HIV Transmission: A Systematic Review and Meta-Analysis , 2014, PLoS medicine.

[33]  S. Ellington,et al.  Safety of tenofovir during pregnancy for the mother and fetus: a systematic review. , 2013, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[34]  M. Newell,et al.  The Contribution of Maternal HIV Seroconversion During Late Pregnancy and Breastfeeding to Mother-to-Child Transmission of HIV , 2012, Journal of acquired immune deficiency syndromes.

[35]  L. Moulton,et al.  Mother to child transmission of HIV among Zimbabwean women who seroconverted postnatally: prospective cohort study , 2010, BMJ : British Medical Journal.

[36]  S. Lockman,et al.  Acute maternal HIV infection during pregnancy and breast-feeding: substantial risk to infants. , 2009, The Journal of infectious diseases.

[37]  P. Harris,et al.  Research electronic data capture (REDCap) - A metadata-driven methodology and workflow process for providing translational research informatics support , 2009, J. Biomed. Informatics.

[38]  R. Spitzer,et al.  The Patient Health Questionnaire-2: Validity of a Two-Item Depression Screener , 2003, Medical care.

[39]  J. Sinacore,et al.  HITS: a short domestic violence screening tool for use in a family practice setting. , 1998, Family medicine.