Structure and biological role of vitronectin.

INTRODUCTION 275 DISTRIBUTION OF VITRONECTIN . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 276 STRUCTURE OF THE VITRONECTIN MOLECULE 278 Physical Properties . . . . . . . . . . . . . . . . . . . . . . . 278 Domain Structure and Binding Sites .. 280 BIOLOGICAL FUNCTIONS OF VITRONECTIN . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 287 Vitronectin Function in Cellular Adhesion. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 287 Vitronectin Function in Immune Defense 293 Vitronectin Function in Hemostasis ...... . 295 CONCLUSION AND PERSPECTiVES 300

[1]  B. Dahlbäck,et al.  Immunohistochemical studies on vitronectin in elastic tissue disorders, cutaneous amyloidosis, lichen ruber planus and porphyria. , 1988, Acta dermato-venereologica.

[2]  E Ruoslahti,et al.  Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors. , 1986, Science.

[3]  J. Mimuro.  [Type 1 plasminogen activator inhibitor]. , 1990, Rinsho byori. The Japanese journal of clinical pathology.

[4]  D. Barnes,et al.  Characterization of human serum spreading factor with monoclonal antibody. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[5]  A. Vaheri,et al.  Directed plasminogen activation at the surface of normal and malignant cells. , 1991, Advances in cancer research.

[6]  W. Kolb,et al.  The membrane attack mechanism of complement. Isolation and subunit composition of the C5b-9 complex , 1975, The Journal of experimental medicine.

[7]  T. Mollnes,et al.  S‐Protein Is Synthesized by Human Monocytes and Macrophages in Vitro , 1989, Scandinavian journal of immunology.

[8]  D. Barnes,et al.  A biologically active thrombin cleavage product of human serum spreading factor. , 1984, Biochemical and biophysical research communications.

[9]  K. Preissner,et al.  Modulation of Heparin Cofactor II Function by S Protein (Vitronectin) and Formation of a Ternary S Protein-Thrombin-Heparin Cofactor II Complex , 1988, Thrombosis and Haemostasis.

[10]  K. Preissner,et al.  Attachment of cultured human endothelial cells is promoted by specific association with S protein (vitronectin) as well as with the ternary S protein-thrombin-antithrombin III complex. , 1988, Blood.

[11]  C. Turner,et al.  Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. , 1988, Annual review of cell biology.

[12]  D. Jenne,et al.  Interaction of complement S-protein with thrombin-antithrombin complexes: a role for the S-protein in haemostasis. , 1985, Thrombosis research.

[13]  T. Foley,et al.  Quantitation of spreading factor in human biologic fluids. , 1984, The Journal of laboratory and clinical medicine.

[14]  O. Sigurdardottir,et al.  Plasminogen activator inhibitor 1 (PAI) is bound to vitronectin in plasma , 1988, FEBS letters.

[15]  J. Reing,et al.  Human spreading factor: Synthesis and response by HepG2 hepatoma cells in culture , 1985, Journal of cellular physiology.

[16]  R. Carrell,et al.  Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins. , 1989, Biochemistry.

[17]  A. Frelinger,et al.  Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion. , 1988, The Journal of biological chemistry.

[18]  K. Preissner,et al.  Neutralization and binding of heparin by S protein/vitronectin in the inhibition of factor Xa by antithrombin III. Involvement of an inducible heparin-binding domain of S protein/vitronectin. , 1987, The Journal of biological chemistry.

[19]  M. Peitsch,et al.  The heparin binding domain of S-protein/vitronectin binds to complement components C7, C8, and C9 and perforin from cytolytic T-cells and inhibits their lytic activities. , 1988, Biochemistry.

[20]  K. Preissner,et al.  Specific interaction of vitronectin with the cell-secreted protease inhibitor glia-derived nexin and its thrombin complex. , 1990, European journal of biochemistry.

[21]  G. Campbell,et al.  A major difference between serum and fibronectin in the divalent cation requirement for adhesion and spreading of BHK21 cells. , 1987, Journal of cell science.

[22]  E. Ruoslahti,et al.  Complete amino acid sequence of human vitronectin deduced from cDNA. Similarity of cell attachment sites in vitronectin and fibronectin. , 1985, The EMBO journal.

[23]  Plasma vitronectin polymorphism in normal subjects and patients with disseminated intravascular coagulation. , 1988 .

[24]  E Ruoslahti,et al.  New perspectives in cell adhesion: RGD and integrins. , 1987, Science.

[25]  E. Engvall,et al.  Cell attachment on replicas of SDS polyacrylamide gels reveals two adhesive plasma proteins , 1982, The Journal of cell biology.

[26]  M. Lampugnani,et al.  An Arg-Gly-Asp sequence within thrombin promotes endothelial cell adhesion , 1991, The Journal of cell biology.

[27]  K. Preissner,et al.  Identification of and partial characterization of platelet vitronectin: evidence for complex formation with platelet-derived plasminogen activator inhibitor-1. , 1989, Blood.

[28]  E. Ruoslahti,et al.  cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[29]  D. Pepper,et al.  The Different Forms of Antithrombin III in Serum , 1977, Thrombosis and Haemostasis.

[30]  T. Wun,et al.  Affinity purification of active plasminogen activator inhibitor-1 (PAI-1) using immobilized anhydrourokinase. Demonstration of the binding, stabilization, and activation of PAI-1 by vitronectin. , 1989, The Journal of biological chemistry.

[31]  R. Eisman,et al.  Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors. , 1988, The Journal of clinical investigation.

[32]  R. Bloch,et al.  Vitronectin at sites of cell-substrate contact in cultures of rat myotubes , 1986, The Journal of cell biology.

[33]  P. McKeown-Longo,et al.  Interaction of the 70,000-mol-wt amino-terminal fragment of fibronectin with the matrix-assembly receptor of fibroblasts , 1985, The Journal of cell biology.

[34]  D. Cheresh,et al.  Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor. , 1987, The Journal of biological chemistry.

[35]  K. Danø,et al.  Plasminogen activators, tissue degradation, and cancer. , 1985, Advances in cancer research.

[36]  P. McKeown-Longo,et al.  Plasminogen activator inhibitor type I stabilizes vitronectin-dependent adhesions in HT-1080 cells , 1990, The Journal of cell biology.

[37]  H. Rus,et al.  Immunohistochemical localization of C5b-9, S-protein, C3d and apolipoprotein B in human arterial tissues with atherosclerosis. , 1987, Atherosclerosis.

[38]  K. Preissner,et al.  The membrane attack complex of complement: relation of C7 to the metastable membrane binding site of the intermediate complex C5b-7. , 1985, Journal of immunology.

[39]  D. Lane,et al.  Neutralization of heparin-related saccharides by histidine-rich glycoprotein and platelet factor 4. , 1986, The Journal of biological chemistry.

[40]  K. Preissner,et al.  Physicochemical characterization of human S-protein and its function in the blood coagulation system. , 1985, The Biochemical journal.

[41]  H. Müller-Eberhard,et al.  Binding of desoxycholate, phosphatidylcholine vesicles, lipoprotein and of the S-protein to complexes of terminal complement components. , 1978, Journal of immunology.

[42]  D. Jenne,et al.  Molecular cloning of S‐protein, a link between complement, coagulation and cell‐substrate adhesion. , 1985, The EMBO journal.

[43]  R. Bar-Shavit,et al.  Mediation of cellular events by thrombin. , 1986, International review of experimental pathology.

[44]  D. Cheresh,et al.  Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells , 1989, Cell.

[45]  S. Lam,et al.  Chemical cross-linking of arginyl-glycyl-aspartic acid peptides to an adhesion receptor on platelets. , 1988, The Journal of biological chemistry.

[46]  E. Podack,et al.  Vitronectin binds to activated human platelets and plays a role in platelet aggregation. , 1990, The Journal of clinical investigation.

[47]  E. Plow,et al.  Plasminogen receptors: Ubiquitous sites for cellular regulation of fibrinolysis , 1988 .

[48]  A. Frelinger,et al.  Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers. , 1990, The Journal of biological chemistry.

[49]  M. Elliott,et al.  Identification of a novel integrin beta subunit expressed on cultured monocytes (macrophages). Evidence that one alpha subunit can associate with multiple beta subunits. , 1990, The Journal of biological chemistry.

[50]  J. Mimuro,et al.  Purification of a protein from bovine plasma that binds to type 1 plasminogen activator inhibitor and prevents its interaction with extracellular matrix. Evidence that the protein is vitronectin. , 1989, The Journal of biological chemistry.

[51]  Tadashi,et al.  Identification of the collagen-binding domain of vitronectin using monoclonal antibodies. , 1988, Cell structure and function.

[52]  J. Reilly,et al.  Vitronectin (serum spreading factor): its localisation in normal and fibrotic tissue. , 1988, Journal of clinical pathology.

[53]  T. Lint,et al.  Serum lipoproteins and C567-INH activity. , 1977, Journal of immunology.

[54]  R. Inhorn,et al.  Phosphorylation of vitronectin by a protein kinase in human plasma. Identification of a unique phosphorylation site in the heparin-binding domain. , 1988, The Journal of biological chemistry.

[55]  H. Müller-Eberhard,et al.  Isolation of a human erythrocyte membrane protein capable of inhibiting expression of homologous complement transmembrane channels. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[56]  Richard O. Hynes,et al.  Integrins: A family of cell surface receptors , 1987, Cell.

[57]  B. Dahlbäck,et al.  Vitronectin shows complement-independent binding to isolated keratin filament aggregates. , 1989, The Journal of investigative dermatology.

[58]  F. A. Bennett,et al.  A comparison of the biological activities of the cell-adhesive proteins vitronectin and fibronectin. , 1989, Journal of cell science.

[59]  N. Seno,et al.  Diversities in animal vitronectins. Differences in molecular weight, immunoreactivity and carbohydrate chains. , 1990, Biochimica et biophysica acta.

[60]  E. Ruoslahti,et al.  Arg-Gly-Asp: A versatile cell recognition signal , 1986, Cell.

[61]  D. Tollefsen,et al.  The presence of methionine or threonine at position 381 in vitronectin is correlated with proteolytic cleavage at arginine 379. , 1990, The Journal of biological chemistry.

[62]  T. Lindahl,et al.  Evidence for a Discrete Binding Protein of Plasminogen Activator Inhibitor in Plasma , 1988, Thrombosis and Haemostasis.

[63]  K. Burridge,et al.  The distribution of distinct integrins in focal contacts is determined by the substratum composition. , 1989, Journal of cell science.

[64]  B. Dahlbäck,et al.  Characterization of human S protein, an inhibitor of the membrane attack complex of complement. Demonstration of a free reactive thiol group. , 1985, Biochemistry.

[65]  L. T. Hunt,et al.  A domain structure common to hemopexin, vitronectin, interstitial collagenase, and a collagenase homolog. , 1987, Protein sequences & data analysis.

[66]  A. D'apice,et al.  SP-40,40, a newly identified normal human serum protein found in the SC5b-9 complex of complement and in the immune deposits in glomerulonephritis. , 1988, The Journal of clinical investigation.

[67]  T. Hunter,et al.  A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C. , 1989, The EMBO journal.

[68]  D. Lawrence,et al.  Structure-function studies of the SERPIN plasminogen activator inhibitor type 1. Analysis of chimeric strained loop mutants. , 1990, The Journal of biological chemistry.

[69]  E. Podack,et al.  Membrane attack by complement. , 1984, Molecular immunology.

[70]  J W Smith,et al.  The Arg-Gly-Asp binding domain of the vitronectin receptor. Photoaffinity cross-linking implicates amino acid residues 61-203 of the beta subunit. , 1988, The Journal of biological chemistry.

[71]  Kenneth M. Yamada,et al.  Site-directed mutagenesis of the cell-binding domain of human fibronectin: Separable, synergistic sites mediate adhesive function , 1988, Cell.

[72]  H. Weiss,et al.  Fibrinogen-independent platelet adhesion and thrombus formation on subendothelium mediated by glycoprotein IIb-IIIa complex at high shear rate. , 1989, The Journal of clinical investigation.

[73]  K. Preissner.  Anticoagulant potential of endothelial cell membrane components. , 1988, Haemostasis.

[74]  A. Bershadsky,et al.  Visualization of cellular focal contacts using a monoclonal antibody to 80 kD serum protein adsorbed on the substratum. , 1983, Experimental cell research.

[75]  A. Vaheri,et al.  Distinct localizations of urokinase-type plasminogen activator and its type 1 inhibitor under cultured human fibroblasts and sarcoma cells , 1987, The Journal of cell biology.

[76]  N. Hogg,et al.  Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis , 1990, Nature.

[77]  K. Preissner,et al.  Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin). , 1988, The Journal of biological chemistry.

[78]  E. Marciniak,et al.  High Molecular Weight Forms of Antithrombin III Complexes in Blood , 1983, Thrombosis and Haemostasis.

[79]  D. Mosher,et al.  On the identity of vitronectin and S-protein: immunological crossreactivity and functional studies. , 1986, Blood.

[80]  O. Garson,et al.  Plasma cell membrane glycoprotein PC-1. cDNA cloning of the human molecule, amino acid sequence, and chromosomal location. , 1990, The Journal of biological chemistry.

[81]  K. Preissner,et al.  Specific binding of the human S protein (vitronectin) to streptococci, Staphylococcus aureus, and Escherichia coli , 1987, Infection and immunity.

[82]  E. Dejana,et al.  Modulation of vitronectin receptor binding by membrane lipid composition. , 1990, The Journal of biological chemistry.

[83]  W. T. Chen,et al.  Immunoelectron microscopic studies of the sites of cell-substratum and cell-cell contacts in cultured fibroblasts , 1982, The Journal of cell biology.

[84]  E. Levin,et al.  Association of a plasminogen activator inhibitor (PAI-1) with the growth substratum and membrane of human endothelial cells , 1987, The Journal of cell biology.

[85]  Russell F. Doolittle,et al.  Computer-based characterization of epidermal growth factor precursor , 1984, Nature.

[86]  M. Shin,et al.  Homologous species restriction in lysis of human erythrocytes: a membrane-derived protein with C8-binding capacity functions as an inhibitor. , 1986, Journal of immunology.

[87]  H. Müller-Eberhard,et al.  SC5b‐7, SC5b‐8 and SC5b‐9 complexes of complement: ultrastructure and localization of the S‐protein (vitronectin) within the macromolecules , 1989, European journal of immunology.

[88]  J. Mimuro,et al.  Extracellular matrix of cultured bovine aortic endothelial cells contains functionally active type 1 plasminogen activator inhibitor. , 1987, Blood.

[89]  E. Ruoslahti,et al.  Domain structure of vitronectin. Alignment of active sites. , 1984, The Journal of biological chemistry.

[90]  P. Højrup,et al.  Sequence location of a putative transglutaminase cross‐linking site in human vitronectin , 1990, FEBS letters.

[91]  D. Heinegård,et al.  The primary structure of a cell-binding bone sialoprotein. , 1988, The Journal of biological chemistry.

[92]  D. Ledbetter,et al.  Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa. , 1988, The Journal of clinical investigation.

[93]  K. Stenn,et al.  Epibolin: a protein of human plasma that supports epithelial cell movement. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[94]  M. Hayashi,et al.  Novel purification of vitronectin from human plasma by heparin affinity chromatography. , 1988, Cell structure and function.

[95]  Erkki Ruoslahti,et al.  Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule , 1984, Nature.

[96]  L. Fryklund,et al.  Primary structure of somatomedin B A growth hormone‐dependent serum factor with protease inhibiting activity , 1978, FEBS letters.

[97]  D. Cheresh.  Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[98]  J. Mimuro,et al.  Binding of type 1 plasminogen activator inhibitor to the extracellular matrix of cultured bovine endothelial cells. , 1989, The Journal of biological chemistry.

[99]  S. Shaltiel,et al.  The phosphorylation of the two‐chain form of vitronectin by protein kinase A is heparin dependent , 1990, FEBS letters.

[100]  J. Tschopp,et al.  Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasma: identity to sulfated glycoprotein 2, a constituent of rat testis fluid. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[101]  M. Ginsberg,et al.  Cytoadhesins, Integrins, and Platelets , 1988, Thrombosis and Haemostasis.

[102]  S. Shaltiel,et al.  Vitronectin is phosphorylated by a cAMP-dependent protein kinase released by activation of human platelets with thrombin. , 1988, Biochemical and biophysical research communications.

[103]  D. Mosher,et al.  Interactions of thrombospondin with endothelial cells: receptor- mediated binding and degradation , 1987, The Journal of cell biology.

[104]  K. Yamada,et al.  Vitronectin exists in two structurally and functionally distinct forms in human plasma. , 1989, Biochimica et biophysica acta.

[105]  A. D'apice,et al.  Localization of Terminal Complement Components, S‐Protein and Sp‐40,40 in Renal Biopsies , 1989, Pathology.

[106]  E. Ruoslahti,et al.  Association of thrombin-antithrombin III complex with vitronectin in serum. , 1985, The Journal of biological chemistry.

[107]  Y. Sugita,et al.  Isolation from human erythrocytes of a new membrane protein which inhibits the formation of complement transmembrane channels. , 1988, Journal of biochemistry.

[108]  M A Shifman,et al.  The in vivo metabolism of antithrombin III and antithrombin III complexes. , 1982, The Journal of biological chemistry.

[109]  E. Ruoslahti,et al.  Vitronectin--a major cell attachment-promoting protein in fetal bovine serum. , 1985, Experimental cell research.

[110]  M. Kazatchkine,et al.  Immunohistochemical study of complement S protein (Vitronectin) in normal and diseased human kidneys: relationship to neoantigens of the C5b-9 terminal complex. , 1989, Clinical and experimental immunology.

[111]  M. Lark,et al.  The fibronectin cell attachment sequence Arg-Gly-Asp-Ser promotes focal contact formation during early fibroblast attachment and spreading , 1987, The Journal of cell biology.

[112]  F. Tatum,et al.  Importance of ligand-induced conformational changes in hemopexin for receptor-mediated heme transport. , 1988, The Journal of biological chemistry.

[113]  C. Parker,et al.  Vitronectin (S protein) is associated with platelets , 1989, British journal of haematology.

[114]  J. Reing,et al.  Heparin-binding properties of human serum spreading factor. , 1985, The Journal of biological chemistry.

[115]  D. Loskutoff,et al.  Serum-derived vitronectin influences the pericellular distribution of type 1 plasminogen activator inhibitor , 1990, The Journal of cell biology.

[116]  K. Stanley.  Homology with hemopexin suggests a possible scavenging function for S‐protein/vitronectin , 1986, FEBS letters.

[117]  S. Cooper,et al.  Vitronectin production by human yolk sac carcinoma cells resembling parietal endoderm. , 1988, Development.

[118]  E. Engvall,et al.  Interaction of vitronectin with collagen. , 1986, The Journal of biological chemistry.

[119]  O. Sigurdardottir,et al.  Stability of Plasminogen Activator Inhibitor 1 (PAI-1) , 1989, Thrombosis and Haemostasis.

[120]  D. Roelcke,et al.  Paroxysmal nocturnal hemoglobinuria type III. Lack of an erythrocyte membrane protein restricting the lysis by C5b-9. , 1987, The Journal of clinical investigation.

[121]  P. Thiagarajan,et al.  Exposure of binding sites for vitronectin on platelets following stimulation. , 1988, The Journal of biological chemistry.

[122]  T. Akama,et al.  Activation of vitronectin (serum spreading factor) binding of heparin by denaturing agents. , 1985, Journal of biochemistry.

[123]  I. Charo,et al.  Platelet glycoprotein IIb-IIIa-like proteins mediate endothelial cell attachment to adhesive proteins and the extracellular matrix. , 1987, The Journal of biological chemistry.

[124]  S. Cooper,et al.  Vitronectin adsorption on polystyrene and oxidized polystyrene , 1989 .

[125]  Y. Takahashi,et al.  Complete amino acid sequence of human hemopexin, the heme-binding protein of serum. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[126]  K. Preissner,et al.  S protein/vitronectin in chronic liver diseases: correlations with serum cholinesterase, coagulation factor X and complement component C3 , 1987, European journal of haematology.

[127]  K. Preissner,et al.  Role of complement S protein (vitronectin) in adherence of Streptococcus dysgalactiae to bovine epithelial cells. , 1990, American journal of veterinary research.

[128]  S. Itzhaki,et al.  Evidence for inhibitors of the cell surface protease guanidinobenzoatase. , 1986, Journal of enzyme inhibition.

[129]  K. Preissner,et al.  Functional interaction of plasminogen activator inhibitor type 1 (PAI-1) and heparin. , 1991, Biochemistry.

[130]  D. Jenne,et al.  Nucleotide sequence and organization of the human S-protein gene: repeating peptide motifs in the "pexin" family and a model for their evolution. , 1987, Biochemistry.

[131]  L. Liotta,et al.  Spatiotemporal segregation of endothelial cell integrin and nonintegrin extracellular matrix-binding proteins during adhesion events , 1990, The Journal of cell biology.

[132]  L. Patthy,et al.  Detecting distant homologies of mosaic proteins. Analysis of the sequences of thrombomodulin, thrombospondin complement components C9, C8 alpha and C8 beta, vitronectin and plasma cell membrane glycoprotein PC-1. , 1988, Journal of molecular biology.

[133]  A. Dalmasso,et al.  Localization of S protein and its relationship to the membrane attack complex of complement in renal tissue. , 1987, The American journal of pathology.

[134]  H. Müller-Eberhard,et al.  Inhibition of C9 polymerization within the SC5b-9 complex of complement by S-protein. , 1984, Acta pathologica, microbiologica, et immunologica Scandinavica. Supplement.

[135]  R. Hynes,et al.  An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin [see comments] , 1989 .

[136]  M. Salmivirta,et al.  Binding of human syndecan to extracellular matrix proteins. , 1990, The Journal of biological chemistry.

[137]  Y. Sakaki,et al.  Polymorphism of the human vitronectin gene causes vitronectin blood type. , 1990, Biochemical and biophysical research communications.

[138]  H. Müller-Eberhard,et al.  Isolation of human S-protein, an inhibitor of the membrane attack complex of complement. , 1979, The Journal of biological chemistry.