Bioactive compounds, health benefits, and industrial applications of Tartary buckwheat (Fagopyrum tataricum)

Abstract Tartary buckwheat belongs to the family Polygonaceae, which is a traditionally edible and medicinal plant. Due to its various bioactive compounds, the consumption of Tartary buckwheat is correlated to a wide range of health benefits, and increasing attention has been paid to its potential as a functional food. This review summarizes the main bioactive compounds and important bioactivities and health benefits of Tartary buckwheat, emphasizing its protective effects on metabolic diseases and relevant molecular mechanisms. Tartary buckwheat contains a wide range of bioactive compounds, such as flavonoids, phenolic acids, triterpenoids, phenylpropanoid glycosides, bioactive polysaccharides, and bioactive proteins and peptides, as well as D-chiro-inositol and its derivatives. Consumption of Tartary buckwheat and Tartary buckwheat-enriched products is linked to multiple health benefits, e.g., antioxidant, anti-inflammatory, antihyperlipidemic, anticancer, antidiabetic, antiobesity, antihypertensive, and hepatoprotective activities. Especially, clinical studies indicate that Tartary buckwheat exhibits remarkable antidiabetic activities. Various tartary buckwheat -based foods presenting major health benefits as fat and blood glucose-lowering agents have been commercialized. Additionally, to address the safety concerns, i.e., allergic reactions, heavy metal and mycotoxin contaminations, the quality control standards for Tartary buckwheat and its products should be drafted and completed in the future.

[1]  S. Yao,et al.  Selective separation of main flavonoids by combinational use of ionic liquid-loaded microcapsules from crude extract of Tartary buckwheat. , 2021, Food chemistry.

[2]  Huaneng Xu,et al.  Study on the change of flavonoid glycosides to aglycones during the process of steamed bread containing tartary buckwheat flour and antioxidant, α-glucosidase inhibitory activities evaluation in vitro , 2021 .

[3]  P. P. Gallego,et al.  Phenolic profiling and in vitro bioactivities of three medicinal Bryophyllum plants , 2021, Industrial Crops and Products.

[4]  D. Norbäck,et al.  A Review on Epidemiological and Clinical Studies on Buckwheat Allergy , 2021, Plants.

[5]  F. Zhu Buckwheat proteins and peptides: Biological functions and food applications , 2021 .

[6]  B. Šarkanj,et al.  Mycotoxins, Pesticide Residues, and Heavy Metals Analysis of Croatian Cereals , 2021, Microorganisms.

[7]  Zaigui Li,et al.  Anti-diabetic effects of the soluble dietary fiber from tartary buckwheat bran in diabetic mice and their potential mechanisms , 2021, Food & nutrition research.

[8]  H. AbdElgawad,et al.  Laser light as a promising approach to improve the nutritional value, antioxidant capacity and anti-inflammatory activity of flavonoid-rich buckwheat sprouts. , 2020, Food chemistry.

[9]  Yue Chen,et al.  Three‐solvent extracting method comprehensively evaluates phenolics profile and antioxidant activities of Tartary buckwheat , 2020 .

[10]  Dae-Ok Kim,et al.  Matrix solid-phase dispersion extraction method for HPLC determination of flavonoids from buckwheat sprouts , 2020, LWT.

[11]  Lingfeng Wu,et al.  Effects of processing methods on phenolic compositions, anti-oxidant activities and α-glucosidase inhibitory ability of two buckwheat varieties , 2020, Chemical Papers.

[12]  Y. Duan,et al.  Ultrasound-, subcritical water- and ultrasound assisted subcritical water-derived Tartary buckwheat polyphenols show superior antioxidant activity and cytotoxicity in human liver carcinoma cells. , 2020, Food research international.

[13]  S. Park,et al.  Treasure from garden: Bioactive compounds of buckwheat , 2020, Food Chemistry.

[14]  Jian Ming,et al.  Effects of steam explosion pretreatment on the composition and biological activities of tartary buckwheat bran phenolics. , 2020, Food & function.

[15]  Ji-rong Shao,et al.  Antioxidant Capacity, Metal Contents, and Their Health Risk Assessment of Tartary Buckwheat Teas , 2020, ACS omega.

[16]  Narpinder Singh,et al.  Proximate composition, amino acid profile, pasting and process characteristics of flour from different Tartary buckwheat varieties. , 2020, Food research international.

[17]  A. Najda,et al.  Effect of commercial processing on polyphenols and antioxidant activity of buckwheat seeds , 2020, International Journal of Food Science & Technology.

[18]  S. Borovaya,et al.  Some aspects of flavonoid biosynthesis and accumulation in buckwheat plants , 2020, Plant Biotechnology Reports.

[19]  Meiliang Zhou,et al.  Tartary Buckwheat: An Under-utilized Edible and Medicinal Herb for Food and Nutritional Security , 2020, Food Reviews International.

[20]  Xiaoyu Luo,et al.  Isolation and identification of antioxidant peptides from tartary buckwheat albumin (Fagopyrum tataricum Gaertn.) and their antioxidant activities. , 2020, Journal of food science.

[21]  R. Teshima,et al.  Understanding buckwheat allergies for the management of allergic reactions in humans and animals , 2020, Breeding science.

[22]  Yu’e Jiang,et al.  Structural and antioxidant analysis of tartary buckwheat (Fagopyrum tartaricum Gaertn.) 13S globulin. , 2020, Journal of the science of food and agriculture.

[23]  Mohammed Akbar,et al.  Tartary buckwheat extract alleviates alcohol-induced acute and chronic liver injuries through the inhibition of oxidative stress and mitochondrial cell death pathway. , 2020, American journal of translational research.

[24]  Min-jae Kang,et al.  Kaempferol‑3‑O‑β‑rutinoside suppresses the inflammatory responses in lipopolysaccharide‑stimulated RAW264.7 cells via the NF‑κB and MAPK pathways. , 2019, International journal of molecular medicine.

[25]  R. Heddle,et al.  Buckwheat allergy in Australia , 2019, Internal medicine journal.

[26]  Lianxin Peng,et al.  Effect of tartary buckwheat, rutin, and quercetin on lipid metabolism in rats during high dietary fat intake , 2019, Food science & nutrition.

[27]  J. Torres,et al.  The Buckwheat Iminosugar d-Fagomine Attenuates Sucrose-Induced Steatosis and Hypertension in Rats. , 2019, Molecular nutrition & food research.

[28]  Milen I Georgiev,et al.  Strategic enhancement of genetic gain for nutraceutical development in buckwheat: A genomics-driven perspective. , 2019, Biotechnology advances.

[29]  Junsoo Lee,et al.  Relative protective activities of quercetin, quercetin-3-glucoside, and rutin in alcohol-induced liver injury. , 2019, Journal of food biochemistry.

[30]  Yiming Zhou,et al.  The Effect of Tartary Buckwheat Flavonoids in Inhibiting the Proliferation of MGC80-3 Cells during Seed Germination , 2019, Molecules.

[31]  Yu’e Jiang,et al.  Regulatory Function of Buckwheat-Resistant Starch Supplementation on Lipid Profile and Gut Microbiota in Mice Fed with a High-Fat Diet. , 2019, Journal of food science.

[32]  Y. Zheng,et al.  Optimization of Hydrolyzed Crude Extract from Tartary Buckwheat Protein and Analysis of Its Hypoglycemic Activity in Vitro , 2019, IOP Conference Series: Earth and Environmental Science.

[33]  Narpinder Singh,et al.  Effect of infrared roasting on antioxidant activity, phenolic composition and Maillard reaction products of Tartary buckwheat varieties. , 2019, Food chemistry.

[34]  Baojun Xu,et al.  Alteration of phenolic profiles and antioxidant capacities of common buckwheat and tartary buckwheat produced in China upon thermal processing. , 2019, Journal of the science of food and agriculture.

[35]  S. Alakurtti,et al.  Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo. , 2019, ACS chemical neuroscience.

[36]  Feier Cheng,et al.  d- chiro-Inositol Ameliorates High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance via PKCε-PI3K/AKT Pathway. , 2019, Journal of agricultural and food chemistry.

[37]  Qiang Peng,et al.  A mini-review of isolation, chemical properties and bioactivities of polysaccharides from buckwheat (Fagopyrum Mill). , 2019, International journal of biological macromolecules.

[38]  Taehwan Lim,et al.  Flavonoids in common and tartary buckwheat hull extracts and antioxidant activity of the extracts against lipids in mayonnaise , 2019, Journal of Food Science and Technology.

[39]  B. Feng,et al.  Analysis of Flavonoid Metabolites in Buckwheat Leaves Using UPLC-ESI-MS/MS , 2019, Molecules.

[40]  Mak-Soon Lee,et al.  Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats , 2019, Nutrients.

[41]  A. Mankevičienė,et al.  Risk factors for mycotoxin contamination of buckwheat grain and its products , 2018, World Mycotoxin Journal.

[42]  S. Shyur,et al.  Biphasic buckwheat anaphylaxis:Case report and systematic review. , 2018, Asian Pacific journal of allergy and immunology.

[43]  Lijuan Wang,et al.  The analysis of fagopyritols from tartary buckwheat and their anti-diabetic effects in KK-Ay type 2 diabetic mice and HepG2 cells , 2018, Journal of Functional Foods.

[44]  R. Teshima,et al.  Oral Immunotherapy with a Phosphorylated Hypoallergenic Allergen Ameliorates Allergic Responses More Effectively Than Intact Allergen in a Murine Model of Buckwheat Allergy , 2018, Molecular nutrition & food research.

[45]  Ying Zan,et al.  Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt‐mTOR pathway mediated autophagy induction , 2018, Life sciences.

[46]  Ying Xiao,et al.  Tartary buckwheat protein prevented dyslipidemia in high-fat diet-fed mice associated with gut microbiota changes. , 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[47]  J. Torres,et al.  Functional Effects of the Buckwheat Iminosugar D‐Fagomine on Rats with Diet‐Induced Prediabetes , 2018, Molecular nutrition & food research.

[48]  Hui-wen Zhang,et al.  Dynamic changes in polyphenol compounds, antioxidant activity, and PAL gene expression in different tissues of buckwheat during germination. , 2018, Journal of the science of food and agriculture.

[49]  C. Seal,et al.  Buckwheat and CVD Risk Markers: A Systematic Review and Meta-Analysis , 2018, Nutrients.

[50]  Zhuanhua Wang,et al.  Inhibitory site of &agr;-hairpinin peptide from tartary buckwheat has no effect on its antimicrobial activities , 2018, Acta biochimica et biophysica Sinica.

[51]  Z. Zhifeng,et al.  Evaluation of essential and toxic elements concentrations in different parts of buckwheat. , 2018 .

[52]  R. Francik,et al.  Identification of polyphenolic compounds and determination of antioxidant activity in extracts and infusions of buckwheat leaves , 2018, European Food Research and Technology.

[53]  G. Ren,et al.  Determination of Multi-Class Mycotoxins in Tartary Buckwheat by Ultra-Fast Liquid Chromatography Coupled with Triple Quadrupole Mass Spectrometry , 2018, Toxins.

[54]  Lianxin Peng,et al.  Chemical Composition, Antimicrobial and Antioxidant Activities of the Flower Volatile Oils of Fagopyrum esculentum, Fagopyrum tataricum and Fagopyrum Cymosum , 2018, Molecules.

[55]  C. Radauer,et al.  Concomitant sensitization to legumin, Fag e 2 and Fag e 5 predicts buckwheat allergy , 2017, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[56]  Xingbin Yang,et al.  Antihypertensive effects of Tartary buckwheat flavonoids by improvement of vascular insulin sensitivity in spontaneously hypertensive rats. , 2017, Food & function.

[57]  Q. Wei,et al.  Quercitrin extracted from Tartary buckwheat alleviates imiquimod-induced psoriasis-like dermatitis in mice by inhibiting the Th17 cell response , 2017 .

[58]  Hee Kang,et al.  Comparison of Anti-Inflammatory Effects of Flavonoid-Rich Common and Tartary Buckwheat Sprout Extracts in Lipopolysaccharide-Stimulated RAW 264.7 and Peritoneal Macrophages , 2017, Oxidative medicine and cellular longevity.

[59]  Q. Wang,et al.  Tartary buckwheat flavonoids ameliorate high fructose-induced insulin resistance and oxidative stress associated with the insulin signaling and Nrf2/HO-1 pathways in mice. , 2017, Food & function.

[60]  Mak-Soon Lee,et al.  The Inhibitory Effect of Tartary Buckwheat Extracts on Adipogenesis and Inflammatory Response , 2017, Molecules.

[61]  Jae-Hyuk Yu,et al.  Occurrence, Toxicity, and Analysis of Major Mycotoxins in Food , 2017, International journal of environmental research and public health.

[62]  Yanli Ma,et al.  In vitro DNA damage protection and anti‐inflammatory effects of Tartary buckwheats (Fagopyrum tataricum L. Gaertn) fermented by filamentous fungi , 2017 .

[63]  Zhang Xiaoyu,et al.  Dynamic changes in antioxidant activity and biochemical composition of tartary buckwheat leaves during Aspergillus niger fermentation , 2017 .

[64]  R. Jiao,et al.  Cholesterol-Lowering Activity of Tartary Buckwheat Protein. , 2017, Journal of agricultural and food chemistry.

[65]  Jian Ming,et al.  Phenolics extracted from tartary (Fagopyrum tartaricum L. Gaerth) buckwheat bran exhibit antioxidant activity, and an antiproliferative effect on human breast cancer MDA-MB-231 cells through the p38/MAP kinase pathway. , 2017, Food & function.

[66]  Zaigui Li,et al.  Dietary tartary buckwheat intake attenuates insulin resistance and improves lipid profiles in patients with type 2 diabetes: a randomized controlled trial. , 2016, Nutrition research.

[67]  M. Meng,et al.  Structural characterization and inhibition on α-d-glucosidase activity of non-starch polysaccharides from Fagopyrum tartaricum. , 2016, Carbohydrate polymers.

[68]  Zaigui Li,et al.  Protective effect of tartary buckwheat on renal function in type 2 diabetics: a randomized controlled trial , 2016, Therapeutics and clinical risk management.

[69]  J. Nishihira,et al.  Effectiveness of rutin-rich Tartary buckwheat (Fagopyrum tataricum Gaertn.) ‘Manten-Kirari’ in body weight reduction related to its antioxidant properties: A randomised, double-blind, placebo-controlled study , 2016 .

[70]  F. Zhu Chemical composition and health effects of Tartary buckwheat. , 2016, Food chemistry.

[71]  A. Mankevičienė,et al.  The effect of buckwheat groats processing on the content of mycotoxins and phenolic compounds , 2016 .

[72]  I. Jang,et al.  Effect of rutin from tartary buckwheat sprout on serum glucose-lowering in animal model of type 2 diabetes , 2016, Acta pharmaceutica.

[73]  C. Zheng,et al.  Phytochemical and Pharmacological Profiles of Three Fagopyrum Buckwheats , 2016, International journal of molecular sciences.

[74]  Xingbin Yang,et al.  Hypoglycemic and hepatoprotective effects of D-chiro-inositol-enriched tartary buckwheat extract in high fructose-fed mice. , 2015, Food & function.

[75]  Eun Joo Lee,et al.  Quercetin Enhances Chemosensitivity to Gemcitabine in Lung Cancer Cells by Inhibiting Heat Shock Protein 70 Expression. , 2015, Clinical lung cancer.

[76]  Xiaoqing Chen,et al.  Separation of five flavonoids from tartary buckwheat (Fagopyrum tataricum (L.) Gaertn) grains via off-line two dimensional high-speed counter-current chromatography. , 2015, Food chemistry.

[77]  Xingbin Yang,et al.  Protective effects of tartary buckwheat flavonoids on high TMAO diet-induced vascular dysfunction and liver injury in mice. , 2015, Food & function.

[78]  H. Zieliński,et al.  Buckwheat as a Functional Food and Its Effects on Health. , 2015, Journal of agricultural and food chemistry.

[79]  J. Lee,et al.  Tartary buckwheat on nitric oxide-induced inflammation in RAW264.7 macrophage cells. , 2015, Food & function.

[80]  P. De Rossi,et al.  Buckwheat achenes antioxidant profile modulates Aspergillus flavus growth and aflatoxin production. , 2014, International journal of food microbiology.

[81]  Yuan Liu,et al.  Evaluation of Essential and Toxic Element Concentrations in Buckwheat by Experimental and Chemometric Approaches , 2014 .

[82]  Yuying Li,et al.  Flavonoids from tartary buckwheat induce G2/M cell cycle arrest and apoptosis in human hepatoma HepG2 cells. , 2014, Acta biochimica et biophysica Sinica.

[83]  Ying-Jang Lai,et al.  Rutin and quercetin, bioactive compounds from tartary buckwheat, prevent liver inflammatory injury. , 2013, Food & function.

[84]  Zhenhuang Yang,et al.  Effects of Maillard reaction on allergenicity of buckwheat allergen Fag t 3 during thermal processing. , 2013, Journal of the science of food and agriculture.

[85]  Caisheng Wu,et al.  Characterization and identification of the chemical constituents from tartary buckwheat (Fagopyrum tataricum Gaertn) by high performance liquid chromatography/photodiode array detector/linear ion trap FTICR hybrid mass spectrometry. , 2013, Food chemistry.

[86]  C. Zheng,et al.  Cytotoxic phenylpropanoid glycosides from Fagopyrum tataricum (L.) Gaertn. , 2012, Food chemistry.

[87]  W. Hsu,et al.  Fagopyrum tataricum (Buckwheat) Improved High-Glucose-Induced Insulin Resistance in Mouse Hepatocytes and Diabetes in Fructose-Rich Diet-Induced Mice , 2012, Experimental diabetes research.

[88]  C. Janson,et al.  Eating buckwheat cookies is associated with the reduction in serum levels of myeloperoxidase and cholesterol: a double blind crossover study in day-care centre staffs. , 2011, The Tohoku journal of experimental medicine.

[89]  Yuying Li,et al.  Epitope mapping and identification on a 3D model built for the tartary buckwheat allergic protein TBb. , 2011, Acta biochimica et biophysica Sinica.

[90]  J. Barek,et al.  Determination of resveratrol in grains, hulls and leaves of common and tartary buckwheat by HPLC with electrochemical detection at carbon paste electrode , 2011 .

[91]  J. McNeil,et al.  Public health campaigns and obesity - a critique , 2011, BMC public health.

[92]  Bao-Hong Lee,et al.  Buckwheat polysaccharide exerts antiproliferative effects in THP-1 human leukemia cells by inducing differentiation. , 2011, Journal of medicinal food.

[93]  Kexue Zhu,et al.  Anti-Tumor Activity of a Novel Protein Obtained from Tartary Buckwheat , 2010, International journal of molecular sciences.

[94]  Jin-Ming Gao,et al.  Antioxidant activity of Tartary buckwheat bran extract and its effect on the lipid profile of hyperlipidemic rats. , 2009, Journal of agricultural and food chemistry.

[95]  Defeng Wu,et al.  Oxidative Stress and Alcoholic Liver Disease , 2009, Seminars in liver disease.

[96]  G. Ren,et al.  D-chiro-inositol-enriched tartary buckwheat bran extract lowers the blood glucose level in KK-Ay mice. , 2008, Journal of agricultural and food chemistry.

[97]  Rika Nakamura,et al.  Immunological characterization and mutational analysis of the recombinant protein BWp16, a major allergen in buckwheat. , 2008, Biological & pharmaceutical bulletin.

[98]  J. Kayashita,et al.  Preparation of tartary buckwheat protein product and its improving effect on cholesterol metabolism in rats and mice fed cholesterol-enriched diet. , 2007, Journal of food science.

[99]  K. Ahn,et al.  Epidemiological Change of Atopic Dermatitis and Food Allergy in School-Aged Children in Korea between 1995 and 2000 , 2004, Journal of Korean Medical Science.

[100]  O. Sytar,et al.  Bioactive Compounds and Their Biofunctional Properties of Different Buckwheat Germplasms for Food Processing , 2018 .

[101]  C. Seal,et al.  Buckwheat and CVD risk markers , a systematic review and meta-1 analysis 2 3 , 2018 .

[102]  Minhui Li,et al.  Fagopyrum tataricum (L.) Gaertn.: A Review on its Traditional Uses, Phytochemical and Pharmacology , 2017 .

[103]  J. Lee,et al.  Articles : Identification of Triterpenoids and Flavonoids from the Seeds of Tartary Buckwheat , 2013 .

[104]  D. Norbäck,et al.  Effects of common and Tartary buckwheat consumption on mucosal symptoms, headache and tiredness : A double-blind crossover intervention study , 2012 .

[105]  G. Xiao-jun Purification and Monosaccharide Composition Analysis of Tartary Buckwheat Polysaccharides , 2011 .

[106]  Y. Takahashi,et al.  [Buckwheat allergy in 90,000 school children in Yokohama]. , 1998, Arerugi = [Allergy].

[107]  The Inhibitory Effect , 2022 .