Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer

[1]  T. Ma,et al.  Biological roles of RNA m5C modification and its implications in Cancer immunotherapy , 2022, Biomarker research.

[2]  V. Mazzaferro,et al.  Inflamed and non-inflamed classes of HCC: a revised immunogenomic classification , 2022, Gut.

[3]  V. Mazzaferro,et al.  Immunotherapies for hepatocellular carcinoma , 2021, Nature Reviews Clinical Oncology.

[4]  Jingyuan Fang,et al.  RNA 5-methylcytosine modification and its emerging role as an epitranscriptomic mark , 2021, RNA biology.

[5]  S. Blanco,et al.  The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities , 2021, Molecular Cancer.

[6]  Wen Wang,et al.  CIGAR‐seq, a CRISPR/Cas‐based method for unbiased screening of novel mRNA modification regulators , 2020, Molecular systems biology.

[7]  Weiqi Wang,et al.  CIGAR-seq, a CRISPR/Cas-based method for unbiased screening of novel mRNA modification regulators , 2020, bioRxiv.

[8]  S. Dietmann,et al.  Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6 , 2020, bioRxiv.

[9]  B. Brüne,et al.  The influenza virus NS1A binding protein gene modulates macrophages response to cytokines and phagocytic potential in inflammation , 2020, Scientific Reports.

[10]  T. Kouzarides,et al.  Role of RNA modifications in cancer , 2020, Nature Reviews Cancer.

[11]  T. Preiss,et al.  Multiple links between 5-methylcytosine content of mRNA and translation , 2020, BMC Biology.

[12]  Manel Esteller,et al.  Writers, Readers and Erasers of RNA Modifications in Cancer. , 2020, Cancer letters.

[13]  P. Pandolfi,et al.  Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program , 2019, Acta Neuropathologica.

[14]  M. Merad,et al.  β-catenin activation promotes immune escape and resistance to anti-PD-1 therapy in hepatocellular carcinoma. , 2019, Cancer discovery.

[15]  L. Van Haute,et al.  NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs , 2019, bioRxiv.

[16]  Rui Zhang,et al.  Genome-wide identification of mRNA 5-methylcytosine in mammals , 2019, Nature Structural & Molecular Biology.

[17]  Bradley R. Cairns,et al.  Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution , 2019, Proceedings of the National Academy of Sciences.

[18]  A. Sevilla,et al.  Post-transcriptional regulation by cytosine-5 methylation of RNA. , 2019, Biochimica et biophysica acta. Gene regulatory mechanisms.

[19]  M. Bohnsack,et al.  Eukaryotic 5-methylcytosine (m5C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease , 2019, Genes.

[20]  M. Esteller,et al.  Clinical epigenetics: seizing opportunities for translation , 2018, Nature Reviews Genetics.

[21]  Ping Wang,et al.  NS1-binding protein radiosensitizes esophageal squamous cell carcinoma by transcriptionally suppressing c-Myc , 2018, Cancer communications.

[22]  M. Esteller,et al.  Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features. , 2017, Gastroenterology.

[23]  A. Watkins,et al.  Protein Domain Mimics as Modulators of Protein-Protein Interactions. , 2017, Accounts of chemical research.

[24]  M. Esteller,et al.  Bromodomain inhibitors and cancer therapy: From structures to applications , 2016, Epigenetics.

[25]  Peter A. Jones,et al.  Epigenetic Determinants of Cancer. , 2016, Cold Spring Harbor perspectives in biology.

[26]  Emanuel J. V. Gonçalves,et al.  A Landscape of Pharmacogenomic Interactions in Cancer , 2016, Cell.

[27]  Michaela Frye,et al.  Stem cell function and stress response are controlled by protein synthesis , 2016, Nature.

[28]  Anthony Barsic,et al.  ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure , 2016, Cell.

[29]  Fan Zhang,et al.  Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1α. , 2016, Cell reports.

[30]  Marco Y. Hein,et al.  A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances , 2015, Cell.

[31]  Sandrine Imbeaud,et al.  DNA methylation‐based prognosis and epidrivers in hepatocellular carcinoma , 2015, Hepatology.

[32]  Schraga Schwartz,et al.  Transcriptome-Wide Mapping of 5-methylcytidine RNA Modifications in Bacteria, Archaea, and Yeast Reveals m5C within Archaeal mRNAs , 2013, PLoS genetics.

[33]  F. Tuorto,et al.  RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis , 2012, Nature Structural &Molecular Biology.

[34]  Norman E. Davey,et al.  Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins , 2012, Cell.

[35]  T. Preiss,et al.  Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA , 2012, Nucleic acids research.

[36]  P. Sandy,et al.  Targeting MYC dependence in cancer by inhibiting BET bromodomains , 2011, Proceedings of the National Academy of Sciences.

[37]  R. Young,et al.  BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc , 2011, Cell.

[38]  Hyungwon Choi,et al.  SAINT: Probabilistic Scoring of Affinity Purification - Mass Spectrometry Data , 2010, Nature Methods.

[39]  Derek Y. Chiang,et al.  Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. , 2008, Cancer research.

[40]  T. Wolff,et al.  The kelch protein NS1-BP interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. , 2007, Biochimica et biophysica acta.

[41]  F. Watt,et al.  The RNA Methyltransferase Misu (NSun2) Mediates Myc-Induced Proliferation and Is Upregulated in Tumors , 2006, Current Biology.

[42]  V. Stollar,et al.  Methylation of Sindbis virus "26S" messenger RNA. , 1975, Biochemical and biophysical research communications.

[43]  D T Dubin,et al.  The methylation state of poly A-containing messenger RNA from cultured hamster cells. , 1975, Nucleic acids research.

[44]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..