Specific targeting, cell sorting, and bioimaging with smart magnetic silica core-shell nanomaterials.

Magnetic nanoparticles (MNPs) have been used in various areas, such as in the manufacture of bearings, seals, lubricants, heat carriers, and in printing, recording, and polishing media. [1] One of the rapidlydeveloping research subjects involving MNPs is their application in biological systems, including their application in magnetic resonance imaging (MRI), targeted drug delivery, rapid biological separation, biosensors, and magnetic hyperthermia therapy. [2] The exploration of the interaction between nanostructured materials and living systems is of fundamental and practical interest, and it opens new doors to novel interdisciplinaryresearch field, “nanobioscience”. MNPs exhibited great potential for in vitro and in vivo biomedical application, [3] and the biodistribution of MNPs is stronglyinfluenced bytheir size, charge, and surface chemistry. [4] Recentlypublished reports indicate that magnetic nanoparticles (or microparticles), Fe3O4, conjugated with various targeting molecules or antibodies, can be used to target specific cells in vitro. [5] However, the noncovalent surface modification of nanoparticles

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