Fermentation monitoring and process control.

The use of modern analytical online methods such as two-dimensional fluorescence measurements gives new insights into bioprocesses. With the resulting data, it is not only possible to better understand and document, for example, biotransformations, but also to develop efficient control strategies that lead to better productivity and lower costs.

[1]  A. P. Togna,et al.  Use of a simple mathematical model to predict the behavior of Escherichia coli overproducing β‐lactamase within continuous single‐ and two‐stage reactor systems , 1993, Biotechnology and bioengineering.

[2]  K B Konstantinov,et al.  On‐line monitoring of hybridoma cell growth using a laser turbidity sensor , 1992, Biotechnology and bioengineering.

[3]  J. Bailey,et al.  Observations of aerobic, growing escherichia coli metabolism using an on‐line nuclear magnetic resonance spectroscopy system , 1993, Biotechnology and bioengineering.

[4]  S A Siano.  On the use of the pH control reagent addition rate for fermentation monitoring , 1995, Biotechnology and bioengineering.

[5]  T Seki,et al.  On-line monitoring of cell concentration of Perilla frutescens in a bioreactor. , 1993, Biotechnology and bioengineering.

[6]  B Sonnleitner,et al.  Automatic bioprocess control. 5. Biologically and technically caused effects during cultivation. , 1993, Journal of biotechnology.

[7]  A. Zeng,et al.  Mathematical modeling and analysis of glucose and glutamine utilization and regulation in cultures of continuous mammalian cells , 1995, Biotechnology and bioengineering.

[8]  Urs von Stockar,et al.  Monitoring synchronized oscillating yeast cultures by calorimetry , 1993 .

[9]  G Locher,et al.  On-line measurement in biotechnology: exploitation, objectives and benefits. , 1992, Journal of biotechnology.

[10]  G Locher,et al.  On-line measurement in biotechnology: techniques. , 1992, Journal of biotechnology.

[11]  Helmut Meier,et al.  On-line monitoring of penicillin V during penicillin fermentations: a comparison of two different methods based on flow-injection analysis , 1993 .

[12]  E. Heinzle,et al.  Present and potential applications of mass spectrometry for bioprocess research and control. , 1992, Journal of biotechnology.

[13]  M N Karim,et al.  Artificial neural networks in bioprocess state estimation. , 1992, Advances in biochemical engineering/biotechnology.

[14]  Patrick N. Royce,et al.  A Discussion of Recent Developments in Fermentation Monitoring and Control from a Practical Perspective , 1993 .

[15]  K. Schügerl.  On-Line Process Analysis for Bioreactor Control , 1993 .

[16]  D Petrides,et al.  Computer-aided process analysis and economic evaluation for biosynthetic human insulin production-A case study. , 1995, Biotechnology and bioengineering.

[17]  M M Domach,et al.  Cultivator for NMR studies of suspended cell cultures , 1992, Biotechnology and bioengineering.

[18]  Advanced methods for bioreactor characterization. , 1992, Journal of biotechnology.

[19]  L. Gorton,et al.  Characterization of a sampling unit based on tangential flow filtration for on-line bioprocess monitoring , 1993 .

[20]  C. Diaz,et al.  Adaptive predictive control of dissolved oxygen concentration in a laboratory-scale bioreactor. , 1995, Journal of biotechnology.

[21]  J. G. Kuenen,et al.  Continuous measurement of microbial heat production in laboratory fermentors , 1993, Biotechnology and bioengineering.

[22]  K Schügerl,et al.  Fed‐batch cultivation of recombinant escherichia coli JM103 and production of the fusion protein SPA::EcoRI in a 60‐L working volume airlift tower loop reactor , 1993, Biotechnology and bioengineering.

[23]  Bernd Hitzmann,et al.  The automation of immun-FIA-systems , 1995 .

[24]  H. Widmer,et al.  Characterization of yeast cultivations by steric sedimentation field-flow fractionation. , 1992, Analytical biochemistry.

[25]  John H. T. Luong,et al.  Novel FIA amperometric biosensor system for the determination of glutamine in cell culture systems , 1993 .

[26]  B. Charles,et al.  Analysis of cisapride in neonatal plasma using high-performance liquid chromatography with a base-stable column and fluorescence detection. , 1995, Journal of chromatography. B, Biomedical applications.

[27]  Continuous monitoring of nitrogenase activity in Azotobacter vinelandii fermentation using off‐gas mass spectrometry , 1995, Biotechnology and bioengineering.

[28]  F. Plötz,et al.  Optical sensors for biotechnological applications , 1994 .

[29]  L. Gorton,et al.  Flow-injection analysis of phenols at a graphite electrode modified with co-immobilised laccase and tyrosinase , 1995 .

[30]  Z Lewandowski,et al.  Measurement of local mass transfer coefficient in biofilms , 1995, Biotechnology and bioengineering.

[31]  H Håkanson,et al.  Sampling and sample handling--crucial steps in process monitoring and control. , 1993, Trends in biotechnology.

[32]  B Sonnleitner,et al.  Automatic bioprocess control. 4. A prototype batch of Saccharomyces cerevisiae. , 1993, Journal of biotechnology.

[33]  K. Schügerl,et al.  Modelling and simulation of the growth and enzyme production of Trichoderma reesei Rut C30 , 1993 .

[34]  Gokare A. Ravishankar,et al.  Computer-aided modeling and optimization for capsaicinoid production by immobilized Capsicum frutescens cells. , 1993, Enzyme and microbial technology.

[35]  R. Beckett,et al.  Physical Characterization and Quantification of Bacteria by Sedimentation Field-Flow Fractionation , 1993, Applied and environmental microbiology.

[36]  J Tramper,et al.  On-line control of an immobilized hybridoma culture with multi-channel flow injection analysis. , 1995, Journal of biotechnology.

[37]  H C Lim,et al.  Modeling and optimization of cloned invertase expression in Saccharomyces cerevisiae , 1993, Biotechnology and bioengineering.

[38]  Ren-min Liu,et al.  Flow injection amperometric determination of trace amounts of ammonium using a gas-diffusion cell as the sample loop , 1995 .

[39]  J. Nielsen,et al.  Modelling the growth of filamentous fungi. , 1992, Advances in biochemical engineering/biotechnology.

[40]  W. Yuan,et al.  Effects of oxygen and ethanol on recombinant yeast fermentation for hepatitis B virus surface antigen production: Modeling and simulation studies , 1993, Biotechnology and bioengineering.

[41]  Rimvydas Simutis,et al.  Fuzzy-aided neural network for real-time state estimation and process prediction in the alcohol formation step of production-scale beer brewing , 1993 .

[42]  D S Kompala,et al.  Overexpression of cloned genes using recombinant escherichia coli regulated by a T7 promoter: II. Two‐stage continuous cultures and model simulations , 1993, Biotechnology and bioengineering.

[43]  S Shioya,et al.  Fuzzy control of ethanol concentration its application to maximum glutathione production in yeast fed‐batch culture , 1993, Biotechnology and bioengineering.

[44]  N. Karanth,et al.  Monitoring of biomass in solid state fermentation using light reflectance , 1993 .

[45]  Jens Brandt,et al.  Monitoring and control of recombinant protein production , 1993 .

[46]  K. Hanselmann,et al.  Biological sulfuric acid transformation: Reactor design and process optimization , 1993, Biotechnology and bioengineering.

[47]  K F Reardon,et al.  Immuno- and flow cytometric analytical methods for biotechnological research and process monitoring. , 1992, Journal of biotechnology.

[48]  Prasad Dhurjati,et al.  Real‐Time compensation of the inner filter effect in high‐density bioluminescent cultures , 1993, Biotechnology and bioengineering.

[49]  F. Regnier,et al.  Rapid process monitoring in biotechnology. , 1993, Trends in biotechnology.

[50]  K Schügerl,et al.  Influence of medium composition on the cephalosporin C production with a highly productive strain Cephalosporium acremonium. , 1992, Journal of biotechnology.

[51]  A. Howgrave-Graham,et al.  Image analysis to quantify and measure UASB digester granules , 1993, Biotechnology and bioengineering.

[52]  H Håkanson,et al.  Immunochemically based assays for process control. , 1992, Advances in biochemical engineering/biotechnology.

[53]  D. Lasko,et al.  In situ fermentation monitoring with recombinant firefly luciferase , 1993, Biotechnology and bioengineering.

[54]  H Lüdi,et al.  Flow injection analysis and in-line biosensors for bioprocess control: a comparison. , 1992, Journal of biotechnology.

[55]  G. Belfort,et al.  Construction and evaluation of a metal ion biosensor , 1993, Biotechnology and bioengineering.

[56]  E Tamiya,et al.  A novel BOD sensor based on bacterial luminescence , 1993, Biotechnology and bioengineering.

[57]  J H Luong,et al.  Monitoring glutamine in animal cell cultures using a chemiluminescence fiber optic biosensor , 1993, Biotechnology and bioengineering.