The relation between human papilloma virus serotype infection and colposcopic, cytological and histopathological abnormalities among the Egyptian women: retrospective study

Objective. Correlating Human Papillomavirus (HPV) serotyping, the findings of PAP-smear, colposcopy with colposcopic directed biopsy. Sharing our epidemiological data guides the local health authorities to formalize national screening protocols. Patient and Methods . A retrospective study was conducted at the Gynecological clinic of a tertiary University Hospital during the period between 2015 to 2020. A total of 285 women's medical records were reviewed for epidemiological, clinical presentation and Pap smear, HPV serotypes, colposcopy findings, and colposcopic guided biopsy. The results were plotted and correlated based on histopathological results. Results. HPV substantial risk types were detected in 74 (25.8%), and minimal risk serotypes were detected in 28(9.7%). 16 positivity was evident in 13 (12.03%) patients, followed by HPV 31 serotype in 12(11.1%), HPV-51 detected in 11 (10.8%), HPV 18 positivity in 10 (10.02%), while HPV negative in 128 (44.7%). The sensitivity of colposcopy was higher than Pap smear (93.2% Vs 68.52%); however, its specificity was only 69.1% compared to 96.7% of the Pap smear. Our results demonstrated a high agreement between colposcopy and histology 95.36%. similarly, Pap smear and colposcopy agreement was high up to 98 %, but between Pap smear and histology was 84%. Conclusions. Pairing the result of HPV serotypes with the grade of abnormal cytology, colposcopic appearance, and histopathological findings could improve the early detection of preinvasive lesions.