Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury.

[1]  P. Kochanek,et al.  Promising strategies to minimize secondary brain injury after head trauma , 2003, Critical care medicine.

[2]  R. Ransohoff.  The chemokine system in neuroinflammation: an update. , 2002, The Journal of infectious diseases.

[3]  C. Dinarello,et al.  Elevated Intracranial IL-18 in Humans and Mice after Traumatic Brain Injury and Evidence of Neuroprotective Effects of IL-18—Binding Protein after Experimental Closed Head Injury , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[4]  K. Blomgren,et al.  Interleukin-18 Involvement in Hypoxic–Ischemic Brain Injury , 2002, The Journal of Neuroscience.

[5]  M. Morganti-Kossmann,et al.  Inflammatory response in acute traumatic brain injury: a double-edged sword , 2002, Current opinion in critical care.

[6]  G. Stoll,et al.  Interleukin-18 Expression after Focal Ischemia of the Rat Brain: Association with the Late-Stage Inflammatory Response , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[7]  G. Stoll,et al.  Induction of the proinflammatory cytokine interleukin‐18 by axonal injury , 2001, Journal of neuroscience research.

[8]  J. Hay,et al.  Intracerebroventricular infusions of TNF-α preferentially recruit blood lymphocytes and induce a perivascular leukocyte infiltrate , 2001, Journal of Neuroimmunology.

[9]  L. Marshall.  Head injury: recent past, present, and future. , 2000, Neurosurgery.

[10]  P. Stahel,et al.  Experimental Closed Head Injury: Analysis of Neurological Outcome, Blood–Brain Barrier Dysfunction, Intracranial Neutrophil Infiltration, and Neuronal Cell Death in Mice Deficient in Genes for Pro-Inflammatory Cytokines , 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[11]  H. Joller,et al.  IL-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain injury: relationship to IL-6, TNF-α, TGF-β1 and blood–brain barrier function , 1999, Journal of Neuroimmunology.

[12]  J Q Trojanowski,et al.  Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[13]  J. Hallenbeck,et al.  Dual role of tumor necrosis factor alpha in brain injury. , 1999, Cytokine & growth factor reviews.

[14]  M. Prinz,et al.  Murine Microglial Cells Produce and Respond to Interleukin‐18 , 1999, Journal of neurochemistry.

[15]  A. Faden,et al.  Early neuronal expression of tumor necrosis factor-α after experimental brain injury contributes to neurological impairment , 1999, Journal of Neuroimmunology.

[16]  N. Rothwell,et al.  Cloning of rat brain interleukin-18 cDNA , 1998, Molecular Psychiatry.

[17]  N. Rothwell,et al.  Cytokines and acute neurodegeneration , 1997, Molecular Psychiatry.

[18]  T. Ben-Hur,et al.  Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-α inhibitor and an effective neuroprotectant , 1997, Journal of Neuroimmunology.

[19]  G. Kollias,et al.  TNF-α transgenic and knockout models of CNS inflammation and degeneration , 1997, Journal of Neuroimmunology.

[20]  D. Wallach,et al.  Inhibition of Tumor Necrosis Factor Alpha (TNFα) Activity in Rat Brain is Associated with Cerebroprotection after Closed Head Injury , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[21]  P. Young,et al.  Experimental brain injury induces differential expression of tumor necrosis factor-alpha mRNA in the CNS. , 1996, Brain research. Molecular brain research.

[22]  N. Rothwell,et al.  Cytokines and the nervous system II: actions and mechanisms of action , 1995, Trends in Neurosciences.

[23]  E. Shohami,et al.  Closed Head Injury Triggers Early Production of TNFα and IL-6 by Brain Tissue , 1994 .

[24]  M A Foulkes,et al.  The diagnosis of head injury requires a classification based on computed axial tomography. , 1992, Journal of neurotrauma.

[25]  R. Grossman,et al.  Elevation of tumor necrosis factor in head injury , 1990, Journal of Neuroimmunology.

[26]  O. Ramilo,et al.  Tumor necrosis factor alpha/cachectin and interleukin 1 beta initiate meningeal inflammation , 1990, The Journal of experimental medicine.

[27]  A. Cerami,et al.  The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis , 1990, The Journal of experimental medicine.

[28]  B. Jennett,et al.  ASSESSMENT OF OUTCOME AFTER SEVERE BRAIN DAMAGE A Practical Scale , 1975, The Lancet.

[29]  S. Barnum.  Complement in central nervous system inflammation , 2002, Immunologic research.

[30]  H. Joller,et al.  IL-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain injury: relationship to IL-6, TNF-alpha, TGF-beta1 and blood-brain barrier function. , 1999, Journal of neuroimmunology.

[31]  Y. Goltsev,et al.  Tumor necrosis factor receptor and Fas signaling mechanisms. , 1999, Annual review of immunology.

[32]  G. Kollias,et al.  TNF-alpha transgenic and knockout models of CNS inflammation and degeneration. , 1997, Journal of neuroimmunology.

[33]  R. Zinkernagel,et al.  Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-α double-deficient mice , 1996 .

[34]  R. Zinkernagel,et al.  Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice. , 1996, International immunology.

[35]  D. Wallach,et al.  Inhibition of tumor necrosis factor alpha (TNFalpha) activity in rat brain is associated with cerebroprotection after closed head injury. , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[36]  B. Rowlands,et al.  The presence of tumour necrosis factor in CSF and plasma after severe head injury. , 1994, British journal of neurosurgery.

[37]  E. Shohami,et al.  Closed head injury triggers early production of TNF alpha and IL-6 by brain tissue. , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[38]  B Jennett,et al.  Assessment of outcome after severe brain damage. , 1975, Lancet.