Effects of experimentally decreased or increased oxygen supply in some ophthalmic diseases; practical value for diagnosis, prognosis, and treatment.

ANOXIA THE EFFECTS of anoxia on the normal visual apparatus are well known, 1 and my collaborators and I have made a number of contributions to this field. 2 I should like only to recall that anoxia is able to produce changes in the neurosensory activity, in the intraocular circulation, in the intrinsic and extrinsic ocular motility, and in the normal transparency of the ocular media. As a general rule, one may assume that anoxia has a twofold influence on the visual organ: a direct one, and an indirect one, through general, nervous, and circulatory mechanisms. Neurosensory Activity. —It is known, first of all, that there is in anoxia a reduction of the central visual acuity, 3 which is especially pronounced at low illumination. 4 I noted a comparable reduction in the resolving power of the retina. 2z The visual field shows a slight concentric narrowing, 5 whereas the blind spot,

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