Cell senescence and its implications for nephrology.

In 1985, Kaysen and Meyers ([1][1]) stated that “the mechanisms and the full biochemical and physiologic consequences of renal senescence remain to be fully elucidated.” The present discussion highlights recent advances in cell biology that have implications for renal senescence. The study of

[1]  R. DePinho,et al.  Cellular Senescence Minireview Mitotic Clock or Culture Shock? , 2000, Cell.

[2]  Lynda Chin,et al.  Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice , 2000, Nature.

[3]  J. Shay,et al.  Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology , 2000, Nature Medicine.

[4]  V. Cristofalo A DNA chip off the aging block , 2000, Nature Medicine.

[5]  D. Lockhart,et al.  Mitotic misregulation and human aging. , 2000, Science.

[6]  A. Melk,et al.  Telomere shortening in kidneys with age. , 2000, Journal of the American Society of Nephrology : JASN.

[7]  D. Choudhury,et al.  Advanced glycation end products: a Nephrologist's perspective. , 2000, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[8]  J M Slack,et al.  Stem cells in epithelial tissues. , 2000, Science.

[9]  J. Megyesi,et al.  The lack of a functional p21WAF1/CIP1 gene ameliorates progression to chronic renal failure , 1999 .

[10]  Y. G. Kim,et al.  The cyclin kinase inhibitor p21CIP1/WAF1 limits glomerular epithelial cell proliferation in experimental glomerulonephritis. , 1999, Kidney international.

[11]  Lynda Chin,et al.  p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis , 1999, Cell.

[12]  A. Levey,et al.  A More Accurate Method To Estimate Glomerular Filtration Rate from Serum Creatinine: A New Prediction Equation , 1999, Annals of Internal Medicine.

[13]  L. Guarente,et al.  Molecular Biology of Aging , 1999, Cell.

[14]  T. Kiyono,et al.  Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells , 1998, Nature.

[15]  H. Schwartz,et al.  Comparison of chromosome telomere integrity in multiple tissues from subjects at different ages. , 1998, Cancer genetics and cytogenetics.

[16]  J. Campisi The role of cellular senescence in skin aging. , 1998, The journal of investigative dermatology. Symposium proceedings.

[17]  R K Jain,et al.  Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. , 1998, The Journal of investigative dermatology.

[18]  C. Baylis,et al.  The aging kidney: insights from experimental studies. , 1998, Journal of the American Society of Nephrology : JASN.

[19]  J. Megyesi,et al.  Induction of p21WAF1/CIP1/SDI1 in kidney tubule cells affects the course of cisplatin-induced acute renal failure. , 1998, The Journal of clinical investigation.

[20]  C. Harley,et al.  Extension of life-span by introduction of telomerase into normal human cells. , 1998, Science.

[21]  U. Brunk,et al.  Lipofuscin: Mechanisms of formation and increase with age , 1998, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[22]  D. Haber,et al.  Splicing into Senescence: The Curious Case of p16 and p19ARF , 1997, Cell.

[23]  G. Ruvkun,et al.  The genetics of aging. , 1997, Annual review of genomics and human genetics.

[24]  F. Zindy,et al.  Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging , 1997, Oncogene.

[25]  D. Fliser,et al.  Renal function in the elderly: impact of hypertension and cardiac function. , 1997, Kidney international.

[26]  G. Martin,et al.  The genetics of aging. , 2003, Annual review of genomics and human genetics.

[27]  L. Chin,et al.  Role of the INK4a Locus in Tumor Suppression and Cell Mortality , 1996, Cell.

[28]  W. A. Johnson,et al.  Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[29]  C Roskelley,et al.  A biomarker that identifies senescent human cells in culture and in aging skin in vivo. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[30]  J. Rydström,et al.  Indenoindole depresses lipofuscin formation in cultured neonatal rat myocardial cells , 1995, Mechanisms of Ageing and Development.

[31]  R. Weinberg,et al.  The retinoblastoma protein and cell cycle control , 1995, Cell.

[32]  P. D. Leeuw,et al.  The aging kidney — a review , 1995 .

[33]  T Nadasdy,et al.  Proliferative activity of intrinsic cell populations in the normal human kidney. , 1994, Journal of the American Society of Nephrology : JASN.

[34]  R. S. Sohal,et al.  Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. , 1994, Science.

[35]  G. Hannon,et al.  A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 , 1993, Nature.

[36]  S. Elledge,et al.  The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases , 1993, Cell.

[37]  P. L. Larsen Aging and resistance to oxidative damage in Caenorhabditis elegans. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[38]  J. Bauer,et al.  The aging hypertensive kidney: pathophysiology and therapeutic options. , 1991, The American journal of medicine.

[39]  N. Gourtsoyiannis,et al.  The thickness of the renal parenchyma decreases with age: a CT study of 360 patients. , 1990, AJR. American journal of roentgenology.

[40]  M Tsuchida,et al.  Lipofuscin and lipofuscin-like substances. , 1987, Chemistry and physics of lipids.

[41]  E. Stadtman,et al.  Age-related changes in oxidized proteins. , 1987, The Journal of biological chemistry.

[42]  N. Wongsurawat,et al.  Aging and the kidney. , 1986, Archives of internal medicine.

[43]  B. Brenner,et al.  Effects of aging on the renal glomerulus. , 1986, The American journal of medicine.

[44]  N W Shock,et al.  Longitudinal Studies on the Rate of Decline in Renal Function with Age , 1985, Journal of the American Geriatrics Society.

[45]  J. Veerkamp,et al.  Chemical characterization of glomerular and tubular basement membranes of men of different age. , 1981, Kidney International.

[46]  M. H. Gault,et al.  Prediction of creatinine clearance from serum creatinine. , 1975, Nephron.

[47]  A M Olovnikov,et al.  A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. , 1973, Journal of theoretical biology.

[48]  L. Hayflick,et al.  The serial cultivation of human diploid cell strains. , 1961, Experimental cell research.

[49]  R. DePinho,et al.  Cellular senescence: mitotic clock or culture shock? , 2000, Cell.

[50]  A. Melk,et al.  Rethinking chronic allograft nephropathy: the concept of accelerated senescence. , 1999, Journal of the American Society of Nephrology : JASN.

[51]  J. Megyesi,et al.  The lack of a functional p 21 WAF 1 y CIP 1 gene ameliorates progression to chronic renal failure , 1999 .

[52]  R. Weindruch,et al.  Age-associated alterations of the mitochondrial genome. , 1997, Free radical biology & medicine.

[53]  S. Dimauro,et al.  Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy. , 1994, Human molecular genetics.

[54]  R. Tracy,et al.  Aging of a class of arteries in various mammalian species in relation to the life span. , 1994, Gerontology.

[55]  R. S. Sohal,et al.  Effect of ambient oxygen concentration on lipofuscin accumulation in cultured rat heart myocytes--a novel in vitro model of lipofuscinogenesis. , 1989, Free radical biology & medicine.

[56]  R. Lindeman,et al.  The aging kidney. , 1986, Comprehensive therapy.

[57]  G. Moment,et al.  Molecular Biology of Aging , 1985, Basic Life Sciences.

[58]  Cockcroft Dw,et al.  Prediction of Creatinine Clearance from Serum Creatinine , 1976 .