Ultra-sensitive plasmonic nanosensors for biochemical detection

We report on a highly sensitive plasmon-based nanosensor. This hybrid sensor is composed of a glass tip with a set of gold nanoparticles grafted at its apex. It allows to optimize the excitation and detection of the localized surface plasmon resonance of metal nanoparticles and thus to increase dramatically the sensitivity. First results show the possibility to detect a concentration as low as 10-10 M on a single gold dimer. Furthermore, promising SERS measurements are reported.

[1]  R. Bachelot,et al.  Quantitative analysis of localized surface plasmons based on molecular probing. , 2010, ACS nano.

[2]  J. Kimling,et al.  Turkevich method for gold nanoparticle synthesis revisited. , 2006, The journal of physical chemistry. B.

[3]  Marc Lamy de la Chapelle,et al.  Biological and chemical gold nanosensors based on localized surface plasmon resonance , 2007 .

[4]  P. Royer,et al.  Optimization of SERS-active substrates for near-field Raman spectroscopy , 2003 .

[5]  George C. Schatz,et al.  Electromagnetic mechanism of SERS , 2006 .

[6]  Pascal Royer,et al.  Detection of chemical molecules with integrated plasmonic glass nanotips , 2008 .

[7]  Giorgio Volpe,et al.  Unidirectional Emission of a Quantum Dot Coupled to a Nanoantenna , 2010, Science.

[8]  S. Maier Plasmonics: Fundamentals and Applications , 2007 .

[9]  A Vial,et al.  Spectral degeneracy breaking of the plasmon resonance of single metal nanoparticles by nanoscale near-field photopolymerization. , 2007, Physical review letters.

[10]  Jeffrey N. Anker,et al.  Biosensing with plasmonic nanosensors. , 2008, Nature materials.

[11]  Catherine J. Murphy,et al.  Evidence for Seed-Mediated Nucleation in the Chemical Reduction of Gold Salts to Gold Nanoparticles , 2001 .

[12]  Rodolphe Jaffiol,et al.  Enhancement and quenching regimes in metal-semiconductor hybrid optical nanosources. , 2010, ACS nano.

[13]  Yang Zou,et al.  E-Beam Patterned Gold Nanodot Arrays on Optical Fiber Tips for Localized Surface Plasmon Resonance Biochemical Sensing , 2010, Sensors.

[14]  Franz R. Aussenegg,et al.  Evidence of multipolar excitations in surface enhanced Raman scattering , 2005 .

[15]  R. V. Van Duyne,et al.  A nanoscale optical biosensor: sensitivity and selectivity of an approach based on the localized surface plasmon resonance spectroscopy of triangular silver nanoparticles. , 2002, Journal of the American Chemical Society.

[16]  Glenn P. Goodrich,et al.  Plasmonic enhancement of molecular fluorescence. , 2007, Nano letters.

[17]  P. Royer,et al.  Self-assembly Drives Quantum Dot Photoluminescence , 2009, Journal of Fluorescence.