Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin.

[1]  N. Seidah,et al.  Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2. , 1993, The Biochemical journal.

[2]  M Chrétien,et al.  cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[3]  I. Lindberg,et al.  Purification and characterization of the prohormone convertase PC1(PC3). , 1993, The Journal of biological chemistry.

[4]  M. Chrétien,et al.  Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[5]  T Watanabe,et al.  Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4. , 1993, Journal of biochemistry.

[6]  R. Mains,et al.  The prohormone convertases PC1 and PC2 mediate distinct endoproteolytic cleavages in a strict temporal order during proopiomelanocortin biosynthetic processing. , 1993, The Journal of biological chemistry.

[7]  I. Lindberg,et al.  Posttranslational processing of proenkephalin in AtT-20 cells: evidence for cleavage at a Lys-Lys site. , 1992, Endocrinology.

[8]  T. Takeuchi,et al.  Processing of mutated proinsulin with tetrabasic cleavage sites to bioactive insulin in the non‐endocrine cell line, COS‐7 , 1992, FEBS letters.

[9]  M Chrétien,et al.  Testicular expression of PC4 in the rat: molecular diversity of a novel germ cell-specific Kex2/subtilisin-like proprotein convertase. , 1992, Molecular endocrinology.

[10]  A. Montag,et al.  Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[11]  C. Gorman,et al.  Prohormone convertase-1 will process prorelaxin, a member of the insulin family of hormones. , 1992, Molecular endocrinology.

[12]  N. Seidah,et al.  Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell type-specific processing of human prorenin by the convertase PC1. , 1992, The Journal of biological chemistry.

[13]  A. Rehemtulla,et al.  Preferred sequence requirements for cleavage of pro-von Willebrand factor by propeptide-processing enzymes. , 1992, Blood.

[14]  T. Watanabe,et al.  Sequence requirements for precursor cleavage within the constitutive secretory pathway. , 1992, The Journal of biological chemistry.

[15]  K. Nakayama,et al.  Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression. , 1992, The Journal of biological chemistry.

[16]  N. Seidah,et al.  Distribution and regulation of the prohormone convertases PC1 and PC2 in the rat pituitary. , 1992, Molecular endocrinology.

[17]  I. Lindberg,et al.  Posttranslational Processing of Proenkephalin in SK‐N‐MC Cells: Evidence for Phosphorylation , 1992, Journal of neurochemistry.

[18]  Richard I. Joh,et al.  Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15. , 1991, DNA and cell biology.

[19]  D. Steiner,et al.  Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[20]  K. Nakayama,et al.  Cloning and functional expression of a novel endoprotease involved in prohormone processing at dibasic sites. , 1991, Journal of biochemistry.

[21]  N. Seidah,et al.  PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[22]  I. Lindberg,et al.  Posttranslational modifications of rat proenkephalin overexpressed in Chinese hamster ovary cells. , 1991, Endocrinology.

[23]  D. Steiner,et al.  Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[24]  N. Seidah,et al.  Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. , 1991, Molecular endocrinology.

[25]  K. Nakayama,et al.  Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells. , 1990, The Journal of biological chemistry.

[26]  A. Brake,et al.  Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[27]  J. Hutton.  Subtilisin-like proteinases involved in the activation of proproteins of the eukaryotic secretory pathway. , 1990, Current opinion in cell biology.

[28]  J. Thorner,et al.  Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro- beta-NGF in vivo , 1990, The Journal of cell biology.

[29]  M Chrétien,et al.  cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases. , 1990, DNA and cell biology.

[30]  D. Steiner,et al.  Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2. , 1990, The Journal of biological chemistry.

[31]  J. Thorner,et al.  Intracellular targeting and structural conservation of a prohormone-processing endoprotease. , 1989, Science.

[32]  T. Nakamura,et al.  Yeast KEX2 genes encodes an endopeptidase homologous to subtilisin-like serine proteases. , 1988, Biochemical and biophysical research communications.

[33]  L. Thomas,et al.  Cell-type specific processing of neuroendocrine precursor proteins using vaccinia recombinants. , 1988, Biochimie.

[34]  A. Roebroek,et al.  fur gene expression as a discriminating marker for small cell and nonsmall cell lung carcinomas. , 1987, The Journal of clinical investigation.

[35]  I. Lindberg.  Reserpine-induced alterations in the processing of proenkephalin in cultured chromaffin cells. Increased amidation. , 1986, The Journal of biological chemistry.

[36]  J. Leunissen,et al.  Evolutionary conserved close linkage of the c‐fes/fps proto‐oncogene and genetic sequences encoding a receptor‐like protein. , 1986, The EMBO journal.

[37]  D. Christie,et al.  Identification of a 27‐kDa enkephalin‐containing protein associated with bovine adrenal medullary chromaffin granule membranes by immunoblotting , 1986, FEBS letters.

[38]  J. P. Schwartz,et al.  A reduction of the tone of 5-hydroxytryptamine neurons decreases utilization rates of striatal and hypothalamic enkephalins. , 1984, European journal of pharmacology.

[39]  J. Barchas,et al.  Regional distribution of metorphamide in rat and guinea pig brain. , 1984, Biochemical and biophysical research communications.

[40]  S. Udenfriend,et al.  Biochemistry of the enkephalins and enkephalin-containing peptides. , 1983, Archives of biochemistry and biophysics.

[41]  I. Lindberg,et al.  A high molecular weight form of met5-enkephalin-arg6-gly7-leu8 in rat brain and bovine adrenal chromaffin granules. , 1983, Life sciences.

[42]  S. Dandekar,et al.  Cell-free translation and partial characterization of mRNA coding for enkephalin-precursor protein. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[43]  P. Giraud,et al.  Enkephalins, ACTH, α-MSH and β-endorphin in human pheochromocytomas , 1981, Neuropeptides.

[44]  N. Seidah,et al.  In vitro biosynthesis and chemical characterization of beta-lipotropin, gamma-lipotropin, and beta-endorphin in rat pars intermedia. , 1978, Proceedings of the National Academy of Sciences of the United States of America.