Maturation of circulatory system in three mammalian models of human development.

The review surveys the literature on maturation of vasoconstrictor and vasodilator functions in cerebral, renal and intestinal circulations of three non-primate models of human development. An ovine model has been refined for use at both fetal and neonatal stages of development. Important variables controlling regional circulations in the lamb fetus at term include arterial O2 content and pCO2 (brain), angiotensin-II (kidney) and norepinephrine (small intestine). Blood flow autoregulation to decreasing perfusion pressure has been inferred for the renal circulation of the neonate. A canine model has been employed in the postnatal period, usually later than the first week after birth. Important variables controlling regional circulations in the young puppy include arterial pO2 and pCO2 (brain) and epinephrine and angiotensin-II (kidney). Blood flow autoregulation to decreasing pressure has been demonstrated in the cerebral circulation at birth and in the renal circulation at one week thereafter. The intestinal circulation has not been studied with respect to blood flow control. A porcine model has been examined from birth through at least two months of postnatal life. Important variables controlling regional circulations in swine at birth include adrenergic nerve stimulation, arterial pCO2 (brain), angiotensin-II (kidney) and norepinephrine (kidney and small intestine). Blood flow autoregulation to decreasing perfusion pressure has been demonstrated in the brain by the fourth day, in the kidney by the end of the second week and in the small intestine by the end of the first month after birth. The advantage of each model for further investigation of functional maturation of regional circulatory control is summarized.

[1]  L. Sokoloff,et al.  CHANGES IN BLOOD FLOW IN THE COMPONENT STRUCTURES OF THE DOG BRAIN DURING POSTNATAL MATURATION , 1972, Journal of neurochemistry.

[2]  P. M. Gootman,et al.  Circulatory effects of splanchnic nerve stimulation in developing swine. , 1985, The American journal of physiology.

[3]  A. Logan,et al.  Intrarenal Blood Flow Distribution in Canine Puppies , 1971, Pediatric Research.

[4]  M. Blaufox,et al.  Neonatal changes in renal blood flow distribution in puppies. , 1975, The American journal of physiology.

[5]  M. Rowe,et al.  A critical appraisal of two common "neonatal" experiment subjects. , 1977, Journal of pediatric surgery.

[6]  J. Campbell,et al.  Microcirculatory changes in the gastrointestinal tract of the hypoxic puppy: an electron microscope study. , 1975, Journal of pediatric surgery.

[7]  S. Siegel,et al.  Effects of angiotensin II on blood pressure, plasma renin activity, and aldosterone in the fetal lamb. , 1981, Developmental pharmacology and therapeutics.

[8]  D. Groothuis,et al.  Regional Cerebral Blood Flow in the Newborn Beagle Pup: the Germinal Matrix is a “Low-Flow” Structure , 1982, Pediatric Research.

[9]  M. Entman,et al.  The comparative hemodynamic effects of isoproterenol in chronically instrumented puppies and adult dogs. , 1981, Developmental pharmacology and therapeutics.

[10]  A. Aperia,et al.  Effect of arterial blood pressure reduction on renal hemodynamics in the developing lamb. , 1976, Acta physiologica Scandinavica.

[11]  A. Bell,et al.  Regional distribution of cardiac output in young lambs: effect of cold exposure and treatment with catecholamines , 1972, The Journal of physiology.

[12]  R. Traystman,et al.  Response of cerebral blood flow to changes in PCO2 in fetal, newborn, and adult sheep. , 1982, The American journal of physiology.

[13]  P. M. Gootman,et al.  Autonomic regulation of cardiovascular function in neonates. , 1981, Ciba Foundation symposium.

[14]  W. Ruf,et al.  Intestinal Blood Flow at Various Intraluminal Pressures in the Piglet with Closed Abdomen , 1980, Annals of surgery.

[15]  J. Mattson,et al.  Effects of Asphyxia on Cardiac Output and Organ Blood Flow in the Newborn Piglet , 1978, Pediatric Research.

[16]  J. Bevan,et al.  Regional variation of lamb blood vessel responsiveness to vasoactive agents during fetal development. , 1977, Circulation research.

[17]  P. Jose,et al.  Autoregulation of renal blood flow in the puppy. , 1975, The American journal of physiology.

[18]  A. Evan,et al.  Maturation of the glomerular visceral epithelium and capillary endothelium in the puppy kidney , 1979, The Anatomical record.

[19]  M. Blaufox,et al.  Postnatal changes in renal glomerular blood flow distribution in puppies. , 1973, The Journal of clinical investigation.

[20]  Fisher Dj.  Cardiac output and regional blood flows during hypoxaemia in unanaesthetized newborn lambs. , 1984 .

[21]  P. Jose,et al.  Sensitivity of neonatal renal vasculature to epinephrine. , 1974, The American journal of physiology.

[22]  R. Lubbe,et al.  Factors affecting the maturation of glomerular filtration rate and renal plasma flow in the new‐born dog , 1972, The Journal of physiology.

[23]  D. I. Edelstone,et al.  Fetal intestinal oxygen consumption at various levels of oxygenation. , 1982, The American journal of physiology.

[24]  S. Ashwal,et al.  Patterns of Fetal Lamb Regional Cerebral Blood Flow during and after Prolonged Hypoxia , 1980, Pediatric Research.

[25]  D. Hay,et al.  Ultrastructure of the developing vascular system in the puppy kidney , 1981, The Anatomical record.

[26]  D. Dudgeon,et al.  The effects of gastric hyperosmotic glucose feedings on regional perfusion in the neonatal piglet. , 1981, Journal of pediatric surgery.

[27]  N. Hansen,et al.  Effect of aminophylline on brain blood flow in the newborn piglet. , 1983, Developmental pharmacology and therapeutics.

[28]  P. M. Gootman,et al.  Age-Dependent Cardiovascular Effects of Afferent Stimulation in Neonatal Pigs , 1976 .

[29]  A. Spitzer,et al.  Quantitative changes in the canine glomerular vasculature during development: physiologic implications. , 1981, Kidney international.

[30]  U. Kotagal,et al.  Acute cardiovascular effects of indomethacin in anesthetized newborn dogs. , 1983, Developmental pharmacology and therapeutics.

[31]  N. Hansen,et al.  Gastrointestinal Blood Flow and Oxygen Consumption in the Newborn Lamb: Effect of Chronic Anemia and Acute Hypoxia , 1984, Pediatric Research.

[32]  C. Kennedy,et al.  Effect of Hyperoxia on the Cerebral Ciculation of the Newborn Puppy , 1971, Pediatric Research.

[33]  R. Touloukian,et al.  The pathogenesis of ischemic gastroenterocolitis of the neonate: selective gut mucosal ischemia in asphyxiated neonatal piglets. , 1972, Journal of pediatric surgery.

[34]  D. Weismann,et al.  Ontogeny of Single Glomerular Perfusion Rate in Fetal and Newborn Lambs , 1981, Pediatric Research.

[35]  H. Iwamoto,et al.  Effects of Angiotensin II on the Blood Flow and Its Distribution in Fetal Lambs , 1981, Circulation research.

[36]  S. Ashwal,et al.  Regional Cerebral Blood Flow: Studies in the Fetal Lamb during Hypoxia, Hypercapnia, Addosis, and Hypotension , 1984, Pediatric Research.

[37]  R. Traystman,et al.  Effects of changes in arterial O2 content on cerebral blood flow in the lamb. , 1981, The American journal of physiology.

[38]  M. Blaufox,et al.  The Renin Angiotensin System in Newborn Dogs: Developmental Patterns and Response to Acute Saline Loading , 1980, Pediatric Research.

[39]  R. Gardiner.  Cerebral blood flow and oxidative metabolism during hypoxia and asphyxia in the new‐born calf and lamb. , 1980, The Journal of physiology.

[40]  A. Rudolph,et al.  Baroreflex control of the circulation in chronically instrumented fetal lambs. , 1983 .

[41]  D. I. Edelstone,et al.  Neonatal intestinal oxygen consumption during arterial hypoxemia. , 1983, The American journal of physiology.

[42]  W. Oh,et al.  The renal response to acute asphyxia in spontaneously breathing newborn lambs. , 1984, Early human development.

[43]  R. Vannucci,et al.  Cerebral blood flow and oxygen consumption in the newborn dog. , 1978, The American journal of physiology.

[44]  N. Hansen,et al.  Gastrointestinal blood flow and oxygen consumption in awake newborn piglets: effect of feeding. , 1983, The American journal of physiology.

[45]  L. Papile,et al.  Autoregulation of Cerebral Blood Flow in the Preterm Fetal Lamb , 1985, Pediatric Research.

[46]  D. Fisher,et al.  Ontogeny of the Renin-Angiotensin-Aldosterone System in the Fetal and Newborn Lamb , 1980, Pediatric Research.

[47]  N. Saunders,et al.  Development of the blood-brain barrier. , 1984, Journal of developmental physiology.

[48]  R. Touloukian,et al.  Alimentary circulation in the pup during the postnatal period. , 1971, Archives of surgery.

[49]  C. Friis.  Postnatal development of the pig kidney: ultrastucure of the glomerulus and the proximal tubule. , 1980, Journal of anatomy.

[50]  A. Aperia,et al.  Renal Hemodynamics in the Perinatal Period , 1977 .

[51]  P. M. Gootman,et al.  Cardiovascular responses to arterial and venous hemorrhage in neonatal swine. , 1984, The American journal of physiology.

[52]  F. Smith,et al.  The Renin-Angiotensin System in the Fetal Lamb , 1974, Pediatric Research.

[53]  R. Brennan,et al.  Autoregulation of cerebral blood flow in the newborn dog , 1980, Brain Research.

[54]  Atropine Prevents Increases in Brain Blood Flow during Hypertension in Newborn Piglets , 1984, Pediatric Research.

[55]  C. Friis.  Postnatal development of renal function in piglets: glomerular filtration rate, clearance of PAH and PAH extraction. , 1979, Biology of the neonate.

[56]  D. Dudgeon,et al.  Mild hypothermia: its effect on cardiac output and regional perfusion in the neonatal piglet. , 1980, Journal of pediatric surgery.

[57]  P. Flecknell,et al.  Accurate measurement of cerebral metabolism in the conscious, unrestrained neonatal piglet. II. Glucose and oxygen utilization. , 1982, Biology of the neonate.

[58]  J. Reuter,et al.  Maturation of glomerular blood flow distribution in the new‐born dog , 1973, The Journal of physiology.

[59]  L. Peeters,et al.  Regulation of cerebral blood flow in the ovine fetus. , 1978, The American journal of physiology.

[60]  D. Driscoll,et al.  Comparative Hemodynamic Effects of Isoproterenol, Dopamine, and Dobutamine in the Newborn Dog , 1979, Pediatric Research.

[61]  N. Rothwell,et al.  Effect of noradrenaline on oxygen consumption and tissue blood flow in young pigs. , 1984, Canadian journal of physiology and pharmacology.

[62]  P. M. Gootman,et al.  Maturation-related differences in regional circulatory effects of dopamine infusion in swine. , 1983, Developmental pharmacology and therapeutics.

[63]  U. Kotagal,et al.  Preservation of cerebral autoregulation in the unanesthetized hypoxemic newborn dog , 1982, Brain Research.

[64]  E. Angelakos,et al.  Development of adrenergic innervation in the puppy kidney , 1970, The Anatomical record.

[65]  P. Jose,et al.  Age-dependent renal effects of intrarenal dopamine infusion. , 1984, The American journal of physiology.

[66]  M. Horster,et al.  ostnatal development of renal function: micropuncture and clearance studies in the dog. , 1971, The Journal of clinical investigation.

[67]  W. Tweed,et al.  Arterial Oxygenation Determines Autoregulation of Cerebral Blood Flow in the Fetal Lamb , 1983, Pediatric Research.

[68]  A. Gruskin,et al.  Maturational Changes in Renal Blood Flow in Piglets , 1970, Pediatric Research.

[69]  M. Reivich,et al.  Heterogeneity of local cerebral blood flow-PaCO2 sensitivity in neonatal dogs. , 1980, Journal of applied physiology: respiratory, environmental and exercise physiology.

[70]  A. Aperia,et al.  Maturational Changes in Glomerular Perfusion Rate and Glomerular Filtration Rate in Lambs , 1974, Pediatric Research.

[71]  R. Carey,et al.  Ontogeny of Blood Pressure and the ReninAngiotensin‐Aldosterone System: Sequential Studies in the Newborn Lamb , 1981, Circulation research.

[72]  I. Holzman,et al.  The Effects of Sodium Nitroprusside on Blood Flow and Oxygen Delivery to the Organs of the Hypoxemic Newborn Lamb , 1985, Pediatric Research.

[73]  R. Koehler,et al.  Distribution of Cardiac Output in Fetal and Neonatal Lambs with Acute Respiratory Acidosis , 1984, Pediatric Research.

[74]  N. Hansen,et al.  The Effects of Variations in Paco2 on Brain Blood Flow and Cardiac Output in the Newborn Piglet , 1984, Pediatric Research.

[75]  J. Genest,et al.  The renin-angiotensin system in newborn dogs. , 1971, Canadian journal of physiology and pharmacology.

[76]  S. Siegel.  Decreased Vascular and Increased Adrenal and Renal Sensitivity to Angiotensin II in the Newborn Lamb , 1981, Circulation research.

[77]  W. Oh,et al.  Autoregulation of brain blood flow in the newborn piglet: regional differences in flow reduction during hypotension. , 1982, Early human development.

[78]  R. Lorijn,et al.  Norepinephrine elevation in the fetal lamb: oxygen consumption and cardiac output. , 1980, The American journal of physiology.

[79]  T. Duffy,et al.  Regulation of local cerebral blood flow in normal and hypoxic newborn dogs , 1982, Annals of neurology.