Tuned Hydroxyapatite Materials for Biomedical Applications

Hydroxyapatite stands out between biomaterials due to its properties of osteoconduc- tion and osteoinduction, being adequate to be used in bone grafts. The high stability and flexibility of the structure allows for several biomedical applications, for example, the use as polysaccharide based on the scaffold formulations and the cationic substitu tions occurring through the doping of the material using metals, which may enhance biological characteristics, such as improving the action of combating bacterial infec tions in situ . This study was a research of articles and patents, without and with time restriction (2007–2017), which contain information about hydroxyapatite in the tissue engineering, biomedical, doped with cerium and its properties of antibacterial activity. There were also searches of products and companies that commercialize these types of materials aimed at tissue engineering area. Scopus was used for searched of articles and were EPO, USPTO, and INPI used for patents, and to search for products and compa- nies were used search engines. Few papers were found to associate all the keywords, but the ones found are recent works, thus showing a new area with potential to be investigated. hydroxyapatite, polysaccharides, biopoly mers, scaffold, tissue engineering, odontology, osteoporosis, tooth, bone, cell growth, bone graft, and implants. research; the other is a review. The article entitled “Bioactivation of knitted cellulose scaffolds bystrontium” was published in the year 2008 by Brandt, Muller and Greil, researchers from the Materials Science Department of the University of Erlangen-Nuremberg, Germany. The article discusses the use of the properties of strontium (Sr 2+ ) in the treatment against osteoporosis, its anabolic and nonresorptive activity. The material used was in the scaffold form, which was prepared using a HAp doped with Sr 2+ plus doped cellulose composition. The study evaluated the kinetics of Sr 2+ release during static exposure to simulated body fluid to evaluate the precipitation of carbonated hydroxyapatite under conditions that simulate the inorganic part of human blood plasma. with Antibacterial Hydroxyapatite and scaffold Hydroxyapatite and scaffold and polysaccharide Hydroxyapatite and doped Hydroxyapatite and doped and cerium Hydroxyapatite and doped and antibacterial activity Hydroxyapatite and scaffold and polysaccharide and doped