Added resolution elements for greater informing power in tandem mass spectrometry

Abstract The concepts of information theory have been applied to tandem mass spectrometry. The roles of the added resolution elements which can increase the informing power for chemical analysis were investigated using a triple quadrupole mass spectrometer. It has been demonstrated that the added resolution elements in sample introduction and ionization as well as in the collisionally activated dissociation (CAD) process lead to increased sensitivity and selectivity for both structure elucidation and mixture analysis.