Bone morphogenetic proteins in multiple sclerosis: Role in neuroinflammation

[1]  J. Ukropec,et al.  Bmp4 Promotes a Brown to White-like Adipocyte Shift. , 2016, Cell reports.

[2]  M. Sospedra,et al.  Immunology of Multiple Sclerosis , 2016, Seminars in Neurology.

[3]  S. M. Chuva de Sousa Lopes,et al.  BMP-SMAD signaling: From pluripotent stem cells to cardiovascular commitment. , 2016, Cytokine & growth factor reviews.

[4]  Jill A Hollenbach,et al.  The immunogenetics of multiple sclerosis: A comprehensive review. , 2015, Journal of autoimmunity.

[5]  R. Autio,et al.  Bone Morphogenetic Protein‐2 Induces Donor‐Dependent Osteogenic and Adipogenic Differentiation in Human Adipose Stem Cells , 2015, Stem cells translational medicine.

[6]  Manuel A. Friese,et al.  Immunopathology of multiple sclerosis , 2015, Nature Reviews Immunology.

[7]  Victor G. Martinez,et al.  The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis , 2015, PloS one.

[8]  R. Harland,et al.  Precise spatial restriction of BMP signaling is essential for articular cartilage differentiation , 2015, Development.

[9]  J. Ioannidis,et al.  Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses , 2015, The Lancet Neurology.

[10]  A. Lo,et al.  Treatment of progressive multiple sclerosis: what works, what does not, and what is needed , 2015, The Lancet Neurology.

[11]  J. Grinspan Bone Morphogenetic Proteins: Inhibitors of Myelination in Development and Disease. , 2015, Vitamins and hormones.

[12]  T. Mueller Mechanisms of BMP-Receptor Interaction and Activation. , 2015, Vitamins and hormones.

[13]  A. Kurczewska,et al.  Modulation of bone morphogenic protein signaling in T-cells for cancer immunotherapy , 2014, Journal of immunotoxicology.

[14]  Jeffrey A. Cohen,et al.  Defining the clinical course of multiple sclerosis: the 2013 revisions. , 2014, Neurology.

[15]  M. Costanzi,et al.  Tis21 is required for adult neurogenesis in the subventricular zone and for olfactory behavior regulating cyclins, BMP4, Hes1/5 and Ids , 2014, Front. Cell. Neurosci..

[16]  M C Sogayar,et al.  Bone Morphogenetic Proteins , 2014, Journal of dental research.

[17]  A. Karni,et al.  Elevated and dysregulated bone morphogenic proteins in immune cells of patients with relapsing–remitting multiple sclerosis , 2013, Journal of Neuroimmunology.

[18]  M. Pirinen,et al.  Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis , 2013, Nature Genetics.

[19]  J. Lünemann,et al.  The initiation and prevention of multiple sclerosis , 2012, Nature Reviews Neurology.

[20]  L. P. Chen,et al.  Regulation of Olig2 during astroglial differentiation in the subventricular zone of a cuprizone-induced demyelination mouse model , 2012, Neuroscience.

[21]  M. Costanzi,et al.  Btg1 is Required to Maintain the Pool of Stem and Progenitor Cells of the Dentate Gyrus and Subventricular Zone , 2012, Front. Neurosci..

[22]  S. Vukicevic,et al.  BMP signaling in rats with TNBS-induced colitis following BMP7 therapy. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[23]  I. Konishi,et al.  Differential effects of inhibition of bone morphogenic protein (BMP) signalling on T‐cell activation and differentiation , 2012, European journal of immunology.

[24]  A. Zapata,et al.  Expression of BMPRIA on human thymic NK cell precursors: role of BMP signaling in intrathymic NK cell development. , 2012, Blood.

[25]  K. Sato,et al.  BMP2, BMP4, noggin, BMPRIA, BMPRIB, and BMPRII are differentially expressed in the adult rat spinal cord , 2012, Neuroscience.

[26]  S. Lawler,et al.  Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity. , 2011, Brain : a journal of neurology.

[27]  J. Myklebust,et al.  Bone morphogenetic proteins inhibit CD40L/IL‐21‐induced Ig production in human Bcells: Differential effects of BMP‐6 and BMP‐7 , 2011, European journal of immunology.

[28]  A. Karni,et al.  Low and dysregulated production of follistatin in immune cells of relapsing–remitting multiple sclerosis patients , 2011, Journal of Neuroimmunology.

[29]  Simon C. Potter,et al.  Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis , 2011, Nature.

[30]  H. Hartung,et al.  Enhancing remyelination in disease--can we wrap it up? , 2011, Brain : a journal of neurology.

[31]  T. Walz,et al.  Latent TGF-β structure and activation , 2011, Nature.

[32]  P. Jin,et al.  RNA-Binding Protein FXR2 Regulates Adult Hippocampal Neurogenesis by Reducing Noggin Expression , 2011, Neuron.

[33]  T. Kilpatrick,et al.  Remyelination Is Altered by Bone Morphogenic Protein Signaling in Demyelinated Lesions , 2011, The Journal of Neuroscience.

[34]  N. Bornstein,et al.  Reduced production of noggin by immune cells of patients with relapsing–remitting multiple sclerosis , 2011, Journal of Neuroimmunology.

[35]  T. Kilpatrick,et al.  Modulation of bone morphogenic protein signalling alters numbers of astrocytes and oligodendroglia in the subventricular zone during cuprizone‐induced demyelination , 2010, Journal of neurochemistry.

[36]  F. Gage,et al.  Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. , 2010, Cell stem cell.

[37]  G. Ming,et al.  Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination , 2010, Nature Neuroscience.

[38]  L. Kappos,et al.  Altered expression of miR‐17‐5p in CD4+ lymphocytes of relapsing–remitting multiple sclerosis patients , 2010, European journal of immunology.

[39]  C. Lindsley,et al.  In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. , 2010, ACS chemical biology.

[40]  S. Vukicevic,et al.  Identification of a Key Residue Mediating Bone Morphogenetic Protein (BMP)-6 Resistance to Noggin Inhibition Allows for Engineered BMPs with Superior Agonist Activity* , 2010, The Journal of Biological Chemistry.

[41]  S. Zheng,et al.  Synergistic effect of TGF‐β superfamily members on the induction of Foxp3+ Treg , 2009, European journal of immunology.

[42]  S. Takai,et al.  TGF-β superfamily enhances the antigen-induced IFN-γ production by effector/memory CD8+ T cells , 2009 .

[43]  S. Mundlos,et al.  Mutations in GDF5 Reveal a Key Residue Mediating BMP Inhibition by NOGGIN , 2009, PLoS genetics.

[44]  Hans-Peter Lenhof,et al.  Multiple Sclerosis: MicroRNA Expression Profiles Accurately Differentiate Patients with Relapsing-Remitting Disease from Healthy Controls , 2009, PloS one.

[45]  J. Christian,et al.  Site-specific Cleavage of BMP4 by Furin, PC6, and PC7* , 2009, The Journal of Biological Chemistry.

[46]  J. A. Lozano,et al.  Differential Micro RNA Expression in PBMC from Multiple Sclerosis Patients , 2009, PloS one.

[47]  J. García-Verdugo,et al.  Immune Regulatory Neural Stem/Precursor Cells Protect from Central Nervous System Autoimmunity by Restraining Dendritic Cell Function , 2009, PloS one.

[48]  Elizabeth J. Robertson,et al.  Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo , 2009, Nature Reviews Molecular Cell Biology.

[49]  Xiao-Fan Wang,et al.  Signaling cross-talk between TGF-β/BMP and other pathways , 2009, Cell Research.

[50]  Robin J. M. Franklin,et al.  Remyelination in the CNS: from biology to therapy , 2008, Nature Reviews Neuroscience.

[51]  F. Luyten,et al.  Dynamic activation of bone morphogenetic protein signaling in collagen-induced arthritis supports their role in joint homeostasis and disease , 2008, Arthritis research & therapy.

[52]  A. Prat,et al.  The activation and physiological functions of the proprotein convertases. , 2008, The international journal of biochemistry & cell biology.

[53]  C. Mummery,et al.  Adult Neurogenesis Requires Smad4-Mediated Bone Morphogenic Protein Signaling in Stem Cells , 2008, The Journal of Neuroscience.

[54]  Charles C Hong,et al.  Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. , 2008, Nature chemical biology.

[55]  S. Whittemore,et al.  Bone Morphogenetic Protein Signaling and Olig1/2 Interact to Regulate the Differentiation and Maturation of Adult Oligodendrocyte Precursor Cells , 2007, Stem cells.

[56]  Li-Xin Xiang,et al.  Bone morphogenetic protein. , 2007, Biochemical and biophysical research communications.

[57]  C. Minetti,et al.  Potential drug targets within bone morphogenetic protein signaling pathways. , 2007, Current opinion in pharmacology.

[58]  A. Zapata,et al.  Bone morphogenetic protein‐2/4 signalling pathway components are expressed in the human thymus and inhibit early T‐cell development , 2007, Immunology.

[59]  Ryan M. Anderson,et al.  Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival , 2006, Developmental dynamics : an official publication of the American Association of Anatomists.

[60]  E. Thonar,et al.  Osteogenic protein 1 in synovial fluid from patients with rheumatoid arthritis or osteoarthritis: relationship with disease and levels of hyaluronan and antigenic keratan sulfate , 2006, Arthritis research & therapy.

[61]  E. Frohman,et al.  Multiple sclerosis--the plaque and its pathogenesis. , 2006, The New England journal of medicine.

[62]  J. Massagué,et al.  Smad transcription factors. , 2005, Genes & development.

[63]  J. Masjuán,et al.  Intrathecal synthesis of oligoclonal IgM against myelin lipids predicts an aggressive disease course in MS. , 2005, The Journal of clinical investigation.

[64]  J. Myklebust,et al.  BMP-6 inhibits growth of mature human B cells; induction of Smad phosphorylation and upregulation of Id1 , 2005, BMC Immunology.

[65]  J. Golden,et al.  Oligodendrocyte maturation is inhibited by bone morphogenetic protein , 2004, Molecular and Cellular Neuroscience.

[66]  J. Smolen,et al.  Arthritis Induces Lymphocytic Bone Marrow Inflammation and Endosteal Bone Formation , 2004 .

[67]  Clare Baecher-Allan,et al.  Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis , 2004, The Journal of experimental medicine.

[68]  F. Luyten,et al.  Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis. , 2003, Arthritis and rheumatism.

[69]  Markus Affolter,et al.  Structural basis of BMP signalling inhibition by the cystine knot protein Noggin , 2002, Nature.

[70]  Anja Nohe,et al.  The Mode of Bone Morphogenetic Protein (BMP) Receptor Oligomerization Determines Different BMP-2 Signaling Pathways* , 2002, The Journal of Biological Chemistry.

[71]  R. Rudick,et al.  Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. , 2002, The New England journal of medicine.

[72]  J. Haines,et al.  Genetic basis for clinical expression in multiple sclerosis. , 2002, Brain : a journal of neurology.

[73]  T. Nakayama,et al.  The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor. , 2001, Genes & development.

[74]  M. Luskin,et al.  Retroviral manipulation of the expression of bone morphogenetic protein receptor Ia by SVZa progenitor cells leads to changes in their p19INK4d expression but not in their neuronal commitment , 2001, International Journal of Developmental Neuroscience.

[75]  C. Lucchinetti,et al.  Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy. , 2001, Trends in molecular medicine.

[76]  J. García-Verdugo,et al.  Noggin Antagonizes BMP Signaling to Create a Niche for Adult Neurogenesis , 2000, Neuron.

[77]  Jeffrey A. Golden,et al.  Stage-specific effects of bone morphogenetic proteins on the oligodendrocyte lineage. , 2000, Journal of neurobiology.

[78]  U. Brehm,et al.  The myelin oligodendrocyte glycoprotein (MOG): a model for antibody-mediated demyelination in experimental autoimmune encephalomyelitis and multiple sclerosis. , 2000, Journal of neural transmission. Supplementum.

[79]  J. Dick,et al.  Bone Morphogenetic Proteins Regulate the Developmental Program of Human Hematopoietic Stem Cells , 1999, The Journal of experimental medicine.

[80]  C. Heldin,et al.  Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling , 1997, Nature.

[81]  K. Miyazono,et al.  Smad6 inhibits signalling by the TGF-β superfamily , 1997, Nature.

[82]  M. Mehler,et al.  Bone Morphogenetic Proteins Induce Astroglial Differentiation of Oligodendroglial–Astroglial Progenitor Cells , 1997, The Journal of Neuroscience.

[83]  R. Harland,et al.  The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4 , 1996, Cell.

[84]  A. Bradley,et al.  BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. , 1995, Genes & development.

[85]  J. Massagué,et al.  GS domain mutations that constitutively activate T beta R‐I, the downstream signaling component in the TGF‐beta receptor complex. , 1995, The EMBO journal.

[86]  J. Strominger,et al.  Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein , 1995, Cell.

[87]  V. Rosen,et al.  Novel regulators of bone formation: molecular clones and activities. , 1988, Science.

[88]  V. Rosen,et al.  Purification and characterization of other distinct bone-inducing factors. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[89]  M. Urist,et al.  Bone: Formation by Autoinduction , 1965, Science.

[90]  E. Kabat,et al.  AN ELECTROPHORETIC STUDY OF THE PROTEIN COMPONENTS IN CEREBROSPINAL FLUID AND THEIR RELATIONSHIP TO THE SERUM PROTEINS. , 1942, The Journal of clinical investigation.