Identification of a plasmin-interactive site within the A2 domain of the factor VIII heavy chain.

[1]  Tomoko Matsumoto,et al.  Mechanisms of Plasmin-catalyzed Inactivation of Factor VIII , 2007, Journal of Biological Chemistry.

[2]  D. Strickland,et al.  Identification of coagulation factor VIII A2 domain residues forming the binding epitope for low-density lipoprotein receptor-related protein. , 2006, Biochemistry.

[3]  K. Nogami,et al.  Mechanisms of Interactions of Factor X and Factor Xa with the Acidic Region in the Factor VIII A1 Domain* , 2004, Journal of Biological Chemistry.

[4]  K. Nogami,et al.  Identification of a Factor Xa-interactive Site within Residues 337–372 of the Factor VIII Heavy Chain* , 2004, Journal of Biological Chemistry.

[5]  P. Fay.  Activation of factor VIII and mechanisms of cofactor action. , 2004, Blood reviews.

[6]  K. Nogami,et al.  Altered Interactions between the A1 and A2 Subunits of Factor VIIIa following Cleavage of A1 Subunit by Factor Xa* , 2003, The Journal of Biological Chemistry.

[7]  Hiroshi Suzuki,et al.  A novel mechanism of factor VIII protection by von Willebrand factor from activated protein C-catalyzed inactivation. , 2002, Blood.

[8]  P. Fay,et al.  Cofactor Activities of Factor VIIIa and A2 Subunit following Cleavage of A1 Subunit at Arg336 * , 2002, The Journal of Biological Chemistry.

[9]  E. Pryzdial,et al.  Mechanism of Factor Va Inactivation by Plasmin , 2001, The Journal of Biological Chemistry.

[10]  K. Mann,et al.  The Role of the Membrane in the Inactivation of Factor Va by Plasmin , 2001, The Journal of Biological Chemistry.

[11]  P. Fay,et al.  Cleavage of Factor VIII Heavy Chain Is Required for the Functional Interaction of A2 Subunit with Factor IXa* , 2001, The Journal of Biological Chemistry.

[12]  K. Nogami,et al.  Circulating factor VIII immune complexes in patients with type 2 acquired hemophilia A and protection from activated protein C-mediated proteolysis. , 2001, Blood.

[13]  P. Fay,et al.  Sites in the A2 subunit involved in the interfactor VIIIa interaction. , 2000, The Journal of biological chemistry.

[14]  T. Koide,et al.  Factor VIII C2 Domain Contains the Thrombin-binding Site Responsible for Thrombin-catalyzed Cleavage at Arg1689 * , 2000, The Journal of Biological Chemistry.

[15]  P. Fay,et al.  Regulation of factor VIIIa by human activated protein C and protein S: inactivation of cofactor in the intrinsic factor Xase. , 2000, Blood.

[16]  A. Giles,et al.  Proteolytic processing of human coagulation factor IX by plasmin. , 2000, Blood.

[17]  I. Mikhailenko,et al.  Role of the Low Density Lipoprotein-related Protein Receptor in Mediation of Factor VIII Catabolism* , 1999, The Journal of Biological Chemistry.

[18]  T. Koide,et al.  Role of Factor VIII C2 Domain in Factor VIII Binding to Factor Xa* , 1999, The Journal of Biological Chemistry.

[19]  P. Fay,et al.  Human Inhibitor Antibodies Specific for the Factor VIII A2 Domain Disrupt the Interaction between the Subunit and Factor IXa* , 1999, The Journal of Biological Chemistry.

[20]  F. Giannelli,et al.  Start of UK Confidential Haemophilia A Database: Analysis of 142 Patients by Solid Phase Fluorescent Chemical Cleavage of Mismatch , 1999, Thrombosis and Haemostasis.

[21]  E. Pryzdial,et al.  Plasmin Converts Factor X from Coagulation Zymogen to Fibrinolysis Cofactor* , 1999, The Journal of Biological Chemistry.

[22]  A. Tulinsky,et al.  Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen. , 1998, Biochemistry.

[23]  P. Fay,et al.  Interacting regions in the A1 and A2 subunits of factor VIIIa identified by zero-length cross-linking. , 1997, Blood.

[24]  W. Cao,et al.  [Molecular characterization of genetic defects in hemophilia in Shanghai]. , 1997, Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi.

[25]  G. Card,et al.  A molecular model for the triplicated A domains of human factor VIII based on the crystal structure of human ceruloplasmin. , 1997, Blood.

[26]  J. Healey,et al.  Residues 484-508 Contain a Major Determinant of the Inhibitory Epitope in the A2 Domain of Human Factor VIII (*) , 1995, The Journal of Biological Chemistry.

[27]  P. Fay,et al.  Cleavage of Factor VIII Light Chain Is Required for Maximal Generation of Factor VIIIa Activity (*) , 1995, The Journal of Biological Chemistry.

[28]  P. Lenting,et al.  The Role of Cleavage of the Light Chain at Positions Arg1689 or Arg1721 in Subunit Interaction and Activation of Human Blood Coagulation Factor VIII (*) , 1995, The Journal of Biological Chemistry.

[29]  P. Fay,et al.  Factor IXa protects factor VIIIa from activated protein C. Factor IXa inhibits activated protein C-catalyzed cleavage of factor VIIIa at Arg562. , 1994, The Journal of biological chemistry.

[30]  P. Lenting,et al.  Identification of a binding site for blood coagulation factor IXa on the light chain of human factor VIII. , 1994, The Journal of biological chemistry.

[31]  M. Shima,et al.  A Factor VIII Neutralizing Monoclonal Antibody and a Human Inhibitor Alloantibody Recognizing Epitopes in the C2 Domain Inhibit Factor VIII Binding to von Willebrand Factor and to Phosphatidylserine , 1993, Thrombosis and Haemostasis.

[32]  A. Tulinsky,et al.  The refined structure of the epsilon-aminocaproic acid complex of human plasminogen kringle 4. , 1991, Biochemistry.

[33]  P. Fay,et al.  von Willebrand factor mediates protection of factor VIII from activated protein C-catalyzed inactivation. , 1991, The Journal of biological chemistry.

[34]  J. Sixma,et al.  The effect of von Willebrand factor on activation of factor VIII by factor Xa. , 1990, European journal of biochemistry.

[35]  P. Fay,et al.  Identification of the binding site for activated protein C on the light chain of factors V and VIII. , 1990, The Journal of biological chemistry.

[36]  P. Lollar,et al.  Association of the factor VIII light chain with von Willebrand factor. , 1988, The Journal of biological chemistry.

[37]  V. Marder,et al.  The size of human factor VIII heterodimers and the effects produced by thrombin. , 1986, Biochimica et biophysica acta.

[38]  G. Vehar,et al.  Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity. , 1986, Biochemistry.

[39]  B. Keyt,et al.  Structure of human factor VIII , 1984, Nature.

[40]  B. Keyt,et al.  Expression of active human factor VIII from recombinant DNA clones , 1984, Nature.

[41]  G. Zampighi,et al.  Phospholipid vesicle formation and transmembrane protein incorporation using octyl glucoside. , 1981, Biochemistry.

[42]  P. Fay,et al.  Proteolytic interactions of factor IXa with human factor VIII and factor VIIIa. , 1992, Blood.

[43]  K. Mann,et al.  Surface-dependent reactions of the vitamin K-dependent enzyme complexes. , 1990, Blood.

[44]  A. Tulinsky,et al.  Lysine/fibrin binding sites of kringles modeled after the structure of kringle 1 of prothrombin , 1988, Proteins.