REAL‐TIME APPLICATIONS OF COMPUTERS IN FERMENTATION PROCESSES

Biochemical engineers have been using digital computers in the analysis, modeling, optimization, and control of fermentation processes for about a decade. The objectives of this presentation are to summarize the important advances in the application of real-time computers to control fermentation processes and to discuss the current status and future prospects in this field. Related problems in analysis, modeling, and optimization will be discussed from this limited perspective while noting that these subjects are addressed more broadly in other parts of this volume. The literature on this topic has become quite substantial so it was decided to forego making a comprehensive review so that several representative contributions could be considered in more detail. Comprehensive reviews on general applications of computers to fermentation processes have been published.14

[1]  G. V. Yakovleva,et al.  Algorithm for optimal control of microbiological synthesis , 1974 .

[2]  M. A. Athans,et al.  The role and use of the stochastic linear-quadratic-Gaussian problem in control system design , 1971 .

[3]  Arthur E. Humphrey,et al.  Real‐time estimation of aerobic batch fermentation biomass concentration by component balancing , 1978 .

[4]  G. Corrieu,et al.  Acquisition and handling of data by computer in fermentation installations , 1974 .

[5]  A Constantinides,et al.  Application of the continuous maximum principle to fermentation processes. , 1974, Biotechnology and bioengineering symposium.

[6]  Petar V. Kokotovic,et al.  A nonlinear regulator problem for a model of biological waste treatment , 1971 .

[7]  Henry Y. Wang,et al.  Computer‐aided baker's yeast fermentations , 1977, Biotechnology and bioengineering.

[8]  V M Fishman,et al.  Kinetic model of secondary metabolite production and its use in computation of optimal conditions. , 1974, Biotechnology and bioengineering symposium.

[9]  Arthur E. Humphrey,et al.  Computer Applications in Fermentation Technology , 1979 .

[10]  Marvin Charles,et al.  On‐line measurement of gas‐exchange conditions in fermentation processes , 1975 .

[11]  L. K. Nyiri,et al.  Application of computers in biochemical engineering , 1972 .

[12]  C. Wells,et al.  On the practical application of "A nonlinear regulator problem for a model of biological waste treatment" , 1971 .

[13]  D. D. Dobry,et al.  Computer Applications to Fermentation Operations , 1977 .

[14]  A Constantinides,et al.  Optimization of batch fermentation processes. II. Optimum temperature profiles for batch penicillin fermentations , 1970, Biotechnology and bioengineering.

[15]  G J FULD,et al.  Control applications in fermentation processes. , 1960, Advances in applied microbiology.

[16]  C L Cooney,et al.  Computer‐aided material balancing for prediction of fermentation parameters , 1977, Biotechnology and bioengineering.

[17]  A Constantinides,et al.  Optimization of batch fermentation processes. I. Development of mathematical models for batch penicillin fermentations. , 1970, Biotechnology and bioengineering.