Simultaneous temperature and regional blood volume measurements in human muscle using an MRI fast diffusion technique

The thermal dependence of the translational diffusion coefficient and of the regional blood volume was investigated in vivo by using a special MR pulsed gradient technique with reduced sensitivity to bulk tissue motion. Measurements were done at 0.5 T, using a small gradient insert. The diffusion coefficient of muscle water was calibrated against thermocouple‐measured temperature in vitro, both with the muscle fibers parallel and perpendicular to the diffusion gradient.

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