The core of practical course is to cultivate students' practical and creative abilities. In the problems existing in the practical course of Electronic Information Science and Technology in Harbin University of Science and Technology, the reform and reconstruction of the practical course are carried out based on the results of goal-oriented in order to improve the connotation and quality of the foster of creative talents. With the aim of cultivating students' creative ability, the multi-level practical course system is integrated. Through exploration and practice, the practical course system is effective in training creative talents. And students' creative and practical application ability is significantly improved.