A case report : Akathisia and an unusual symptomatic treatment

We present a case of medication-induced akathisia in a 47-year-old woman with metastatic carcinoma of the ovary. Severe pacing and restlessness started after commencing a subcutaneous infusion with cyclizine 150mg, haloperidol 2.5 mg and oxycodone 20 mg. She was also taking levomepromazine and fluoxetine orally at the time. By making changes to her medication, her symptoms resolved gradually. During the time of convalescence, she gained great symptomatic relief from using exercise pedals and it allowed her to go about usual everyday activities, such as eating and reading, while continuously treading the pedals. Palliative Medicine 2007; 21 : 713—715

[1]  C. Fuchs,et al.  Low-Dose Mirtazapine: A New Option in the Treatment of Antipsychotic-Induced Akathisia. A Randomized, Double-Blind, Placebo- and Propranolol-Controlled Trial , 2006, Biological Psychiatry.

[2]  P. Chandra,et al.  Atypical Antipsychotic–Induced Akathisia with Depression: Therapeutic Role of Mirtazapine , 2006, The Annals of pharmacotherapy.

[3]  J. Eisenchlas,et al.  Low-dose levomepromazine in refractory emesis in advanced cancer patients: an open-label study , 2005, Palliative medicine.

[4]  R. A’Hern,et al.  An open study of methotrimeprazine in the management of nausea and vomiting in patients with advanced cancer , 2005, Supportive Care in Cancer.

[5]  M. Holi,et al.  Prevalence of neuroleptic-induced movement disorders in chronic schizophrenia inpatients. , 2004, The American journal of psychiatry.

[6]  Hee-Jung Byun,et al.  Prevalence and Characteristics of Subjective Akathisia, Objective Akathisia, and Mixed Akathisia in Chronic Schizophrenic Subjects , 2003, Clinical neuropharmacology.

[7]  N. Yasui-Furukori,et al.  Histamine H1-Receptor Antagonists, Promethazine and Homochlorcyclizine, Increase the Steady-State Plasma Concentrations of Haloperidol and Reduced Haloperidol , 2003, Therapeutic drug monitoring.

[8]  C. Fuchs,et al.  Efficacy of low-dose mirtazapine in neuroleptic-induced akathisia: A double-blind randomized placebo-controlled pilot study , 2002, European Neuropsychopharmacology.

[9]  T. Edeki,et al.  Inhibitory effects of H1-antihistamines on CYP2D6- and CYP2C9-mediated drug metabolic reactions in human liver microsomes , 2002, European Journal of Clinical Pharmacology.

[10]  L. Hansen A critical review of akathisia, and its possible association with suicidal behaviour , 2001, Human psychopharmacology.

[11]  J. Skinner,et al.  Levomepromazine for nausea and vomiting in advanced cancer. , 1999, Hospital medicine.

[12]  R. Lane SSRI-Induced extrapyramidal side-effects and akathisia: implications for treatment , 1998, Journal of psychopharmacology.

[13]  C. Caley,et al.  Extrapyramidal Reactions and the Selective Serotonin-Reuptake Inhibitors , 1997, The Annals of pharmacotherapy.

[14]  R. J. Leo,et al.  Movement disorders associated with the serotonin selective reuptake inhibitors. , 1996, The Journal of clinical psychiatry.

[15]  J. Darby,et al.  Haloperidol dose and blood level variability: toxicity and interindividual and intraindividual variability in the nonresponder patient in the clinical practice setting. , 1995, Journal of clinical psychopharmacology.

[16]  G. Williams,et al.  A retrospective study of risk factors of akathisia in terminally ill patients. , 1994, Journal of pain and symptom management.

[17]  S. Lal,et al.  Levomepromazine receptor binding profile in human brain—implications for treatment—resistant schizophrenia , 1993, Acta psychiatrica Scandinavica.

[18]  L. Opler,et al.  Akathisia, suicidality, and fluoxetine. , 1992, The Journal of clinical psychiatry.

[19]  M. Jann,et al.  Pharmacokinetics of Haloperidol , 1989, Clinical pharmacokinetics.

[20]  L. Hollister,et al.  Elimination half-life and bioavailability of haloperidol in schizophrenic patients. , 1985, The Journal of clinical psychiatry.

[21]  D. Stanski,et al.  Haloperidol kinetics after oral and intravenous doses , 1983, Clinical pharmacology and therapeutics.