Chapter 3 – Fundamentals

Abstract : This chapter focuses on important issues related to the flowing sample, such as the flow pattern, sample dispersion and interactions between flowing solutions, which are essential for system design, optimisation and operation. Strategies for visualisation of a flowing sample are also discussed, the commutation principle is highlighted, and guidelines for characterising a flow analyser and related methodologies are provided. The chapter concludes by emphasising the different strategies for obtaining the analytical results.

[1]  L. Danielsson,et al.  Dispersion in phase separators for flow-injection extraction systems , 1986 .

[2]  Jeong‐long Lin,et al.  Measurement of diffusion coefficients of some indoles and ascorbic acid by flow injection analysis , 1990 .

[3]  A. Griffiths.  On the Movement of a Coloured Index along a Capillary Tube, and its Application to the Measurement of the Circulation of Water in a Closed Circuit , 1910 .

[4]  T. J. Cardwell,et al.  Pulsed flow chemistry. A new approach to the generation of concentration profiles in flow analysis , 1998 .

[5]  Miguel Valcárcel Cases,et al.  Flow-injection analysis : principles and applications , 1987 .

[6]  Gary D. Christian,et al.  Split zone flow-injection analysis: an approach to automated dilutions , 1989 .

[7]  G. Taylor.  Dispersion of soluble matter in solvent flowing slowly through a tube , 1953, Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences.

[8]  B. Reis,et al.  The concept of volumetric fraction in flow-injection analysis , 1989 .

[9]  L. Gorton,et al.  Flow injection analysis for glucose and urea with enzyme reactors and on-line dialysis , 1981 .

[10]  E. Toren,et al.  AXIAL DISPERSION IN COILED TUBULAR REACTORS , 1986 .

[11]  W. Gill,et al.  Laminar dispersion in capillaries: Part I. Mathematical analysis , 1965 .

[12]  B. Massey,et al.  Mechanics of Fluids , 2018 .

[13]  A. Yuchi,et al.  Sample dispersion with chemical reaction in a flow-injection system , 1986 .

[14]  J. M. Calatayud,et al.  Multi-insertion of small controlled volumes of solutions in a flow assembly for determination of nitrate (photoreduction) and nitrite with proflavin sulfate , 1998 .

[15]  J. Ruzicka,et al.  Flow injection analysis. principles, applications and trends , 1980 .

[16]  H. Pardue,et al.  Kinetic treatment of unsegmented flow systems : Part 3. Flow-injection system with gradient chamber evaluated with a linearly responding detector , 1986 .

[17]  Hideaki Tokuyama,et al.  Development of a novel moving bed with liquid-pulse and experimental analysis of nickel removal from acidic solution , 2004 .

[18]  F. Krug,et al.  Merging zones in flow injection analysis: Part 6. determination of calcium in natural waters, soil and plant materials with glyoxal bis(2-hydroxyanil) , 1981 .

[19]  D. J. Malcolme-Lawes,et al.  A novel approach to non-segmented flow analysis: Part 3. Nitrate, nitrite and ammonium in waters , 1988, The Journal of automatic chemistry.

[20]  F. Krug,et al.  Zone-sampling processes in flow injection analysis , 1981 .

[21]  T. Korenaga,et al.  Computer-controlled micropump suitable for precise microliter delivery and complete in-line mixing , 1994 .

[22]  H. Poppe,et al.  Dispersion in open tubes and tubes packed with large glass beads , 1981 .

[23]  Á. Ríos,et al.  Kinetics of ion-pair extraction in continuous flow systems , 1989 .

[24]  G. D. Marshall,et al.  Zone fluidics in flow analysis: potentialities and applications , 2003 .

[25]  M. Gisin,et al.  Extensive flow-injection dilution for in-line sample pretreatment , 1988 .

[26]  L. Danielsson,et al.  The analysis of aqueous solutions with ethanol-soluble reagents in a flow injection system , 1984 .

[27]  Paul S. Francis,et al.  Flow analysis based on a pulsed flow of solution: theory, instrumentation and applications. , 2002, Talanta.

[28]  P. B. Oates,et al.  Control of dispersion and variation of reaction coil length in flow injection analyzers by flow reversals , 1987 .

[29]  F. Krug,et al.  Confluent streams in flow injection analysis , 1987 .

[30]  D. Higgs,et al.  Laminar dispersion in flow-injection analysis. , 1981, Talanta.

[31]  K. Johnson,et al.  Determination of phosphate in seawater by flow injection analysis with injection of reagent , 1982 .

[32]  W. Gill,et al.  MECHANISMS AFFECTING DISPERSION AND MISCIBLE DISPLACEMENT , 1969 .

[33]  A Bertsch,et al.  Static micromixers based on large-scale industrial mixer geometry. , 2001, Lab on a chip.

[34]  B. Reis,et al.  Solvent extraction in continuous flow injection analysis , 1978 .

[35]  P. Worsfold,et al.  A critical examination of the components of the Schlieren effect in flow analysis. , 2006, Talanta.

[36]  J. Ruzicka,et al.  The principles and theory of high-speed titrations by flow injection analysis , 1981 .

[37]  D. Betteridge,et al.  A random walk simulation of flow injection analysis , 1984 .

[38]  H. Poppe,et al.  Some theoretical aspects of flow injection analysis , 1980 .

[39]  P. Stockwell.  Automatic Chemical Analysis , 1996 .

[40]  R. Hull,et al.  Dispersion phenomena in flow-injection systems , 1992 .

[41]  A. Townshend,et al.  Flow injection-chemiluminescence determination of propranolol in pharmaceutical preparations , 2003 .

[42]  John Tasman Davies.  Turbulence phenomena;: An introduction to the eddy transfer of momentum, mass, and heat, particularly at interfaces , 1972 .

[43]  G. Beecher,et al.  Laminar-flow bolus shapes in flow injection analysis , 1986 .

[44]  Jaromir Růžička,et al.  Flow injection analysis , 1981 .

[45]  N. Campillo,et al.  Use of submicroliter-volume samples for extending the dynamic range of flow-injection flame atomic absorption spectrometry , 1995 .

[46]  E. Zagatto,et al.  A novel flow-based strategy for implementing differential kinetic analysis. , 2006, Analytica chimica acta.

[47]  A. Fogg,et al.  Flow injection sandwich technique applied to indirect visible spectrophotometric determinations. bromimetric and iodimetric determination of sulphite , 1995 .

[48]  José L. F. C. Lima,et al.  Multicommutation in flow analysis: concepts, applications and trends , 2002 .

[49]  J. Lima,et al.  Multicommutation in flow analysis. Part 1. Binary sampling: concepts, instrumentation and spectrophotometric determination of iron in plant digests , 1994 .

[50]  E H Hansen,et al.  Flow injection analysis: Part VII. Use of ion-selective electrodes for rapid analysis of soil extracts and blood serum. Determination of potassium, sodium and nitrate , 1977 .

[51]  Teruo Takahashi,et al.  Study of sample dispersionin flow injection analysis , 1988 .

[52]  J. Ruzicka,et al.  Flow injection analyses , 1975 .

[53]  E. Zagatto,et al.  An improved flow injection determination of nitrite in waters by using intermittent flows , 1980 .

[54]  Liang-Shih Fan,et al.  Summary paper on fluidization and transport phenomena , 1996 .

[55]  I. Pepe,et al.  Evaluation of transversal and longitudinal dispersion in a flow injection system by exploiting laser induced fluorescence: influence of flow-cell positioning , 2004 .

[56]  B. Reis,et al.  A new device for improving sensitivity and stabilization in flow-injection analysis , 1978 .

[57]  Francisco José Krug,et al.  Sequential injections in flow system as an alternative to gradient exploitation , 1985 .

[58]  J. A. Pulgarín,et al.  Automatic chemiluminescence-based determination of carbaryl in various types of matrices. , 2006, Talanta.

[59]  G. Horvai,et al.  Injection techniques in dynamic flow-through analysis with electroanalytical sensors , 1979 .

[60]  G. Taylor.  Diffusion and Mass Transport in Tubes , 1954 .

[61]  B. Fields,et al.  Kinetic treatment of unsegmented flow systems : Part 2. Detailed Treatment of Flow-Injection Systems with Gradient Chamber , 1981 .

[62]  J. Lima,et al.  Multi-pumping in flow analysis: concepts, instrumentation, potentialities , 2002 .

[63]  I. A. Rufini,et al.  The use of ion exchange resin for reagent immobilization and concentration in flow systems: determination of nickel in steel alloys and iron speciation in waters , 1997 .

[64]  R. Thiers,et al.  A bubble-gating flow cell for continuous-flow analysis. , 1969, Clinical chemistry.

[65]  A. Nogueira,et al.  Multi-site detection in flow analysis , 1993 .

[66]  M. Valcárcel,et al.  Integrated reaction/spectrophotometric detection in unsegmented flow systems , 1988 .

[67]  Elo Harald Hansen,et al.  Flow injection analysis : Part X. theory, techniques and trends , 1978 .

[68]  Á. Ríos,et al.  Continuous sample monitoring by flow reversal methodology , 1992 .

[69]  R. Cattrall,et al.  Time-division multiplex technique for producing concentration profiles in flow analysis , 1998 .

[70]  U. Neue,et al.  Reaction detector with three dimensional coiled open tubes in HPLC , 1982 .

[71]  Víctor Cerdà,et al.  A robust multisyringe system for process flow analysis. Part I. On-line dilution and single point titration of protolytes , 1999 .

[72]  M. Bos,et al.  Dispersion behaviour of solid particles in flow-injection analysis , 1997 .

[73]  Paula R. Fortes,et al.  Mixing chambers in flow analysis: A review , 2009 .

[74]  J. Burguera,et al.  Flow injection and microwave-oven sample decomposition for determination of copper, zinc and iron in whole blood by atomic absorption spectrometry , 1986 .

[75]  Albert Renken,et al.  Modelling of heavy metals adsorption to a chelating resin in a fluidized bed reactor 1 Dedicated to , 1998 .

[76]  Amarjeet S. Bassi,et al.  Radial solids flow structure in a liquid–solids circulating fluidized bed , 2002 .

[77]  S. Kolev,et al.  Description of an axially-dispersed plug flow model for the flow pattern in elements of fluid systems , 1986 .

[78]  M. Gisin,et al.  Hydrodynamically limited precision of gradient techniques in flow injection analysis , 1986 .

[79]  Bo Karlberg,et al.  Comparison of various peak evaluation techniques for limited and extended dynamic ranges in flow injection systems , 1998 .

[80]  J. Ruzicka,et al.  Flow injection analysis : Part III. Comparison of continuous flow spectrophotometry and potentiometry for the rapid determination of the total nitrogen content in plant digests , 1976 .

[81]  J. Toei.  Determination of glucose in clinical samples by flow reversal flow injection analysis. , 1988, The Analyst.

[82]  R. Tijssen.  Axial dispersion and flow phenomena in helically coiled tubular reactors for flow analysis and chromatography , 1980 .

[83]  M. Valcárcel,et al.  Formation of two reaction zones in flow-injection systems for kinetic determinations of cobalt and nickel , 1987 .

[84]  J. Tyson,et al.  Comparison of mixing devices for flow-inection determinations based on doublet peak formation , 1994 .

[85]  J. W. Bridges,et al.  Automation of an energy-transfer immunoassay by using stopped-flow injection analysis with merging zones , 1980 .

[86]  G. D. Owens,et al.  Pulsed-flow instrument for measurement of fast reactions in solution , 1980 .

[87]  H. Mottola,et al.  Kinetics in continuous flow sample processing Chemical Contributions to Dispersion in Flow-Injection Techniques , 1984 .

[88]  J. Tyson.  A simple lecture demonstration of flow injection analysis , 1988 .

[89]  J. Lima,et al.  A critical comparison of analytical flow systems exploiting streamlined and pulsed flows , 2007, Analytical and Bioanalytical Chemistry.

[90]  J. Tyson,et al.  Models for dispersion in flow injection. Part 2. Two tanks in parallel model , 1989 .

[91]  J. Lima,et al.  Evidences of turbulent mixing in multi-pumping flow systems. , 2009, Talanta.

[92]  R. Aris.  On the dispersion of a solute in a fluid flowing through a tube , 1956, Proceedings of the Royal Society of London. Series A. Mathematical and Physical Sciences.

[93]  J. Tyson.  Peak width and reagent dispersion in flow injection analysis , 1986 .

[94]  C. Pasquini.  Mechanical removal of the central sample zone to avoid air bubbles in monosegmented continuous flow analysis , 1986 .

[95]  Elias A.G. Zagatto,et al.  FLOW ANALYSIS | Overview , 2013 .

[96]  D. Betteridge,et al.  A random-walk simulation of flow-injection systems with merging zones , 1987 .

[97]  W. Gill,et al.  Laminar dispersion in capillaries: Part IV. The slug stimulus , 1967 .

[98]  J. Lima,et al.  Fluidized beds in flow analysis: use with ion-exchange separation for spectrophotometric determination of zinc in plant digests , 2006, Analytical and bioanalytical chemistry.

[99]  H. Pardue,et al.  Experimental evaluation of theoretical response equations for an unsegmented flow system with a well-stirred mixing chamber , 1992 .

[100]  Flow injection analysis , 1978 .

[101]  C. Pasquini,et al.  Spectrophotometric Determination of Chromium ( VI ) , Ammonia , and Phosphorus , 2022 .

[102]  D. Betteridge,et al.  Construction of pH gradients in flow-injection analysis and their potential use for multielement analysis in a single sample bolus , 1978 .

[103]  J. Tyson,et al.  Determination of rate constants by a double-line flow injection method incorporating a well-stirred tank reactor. , 1994, Talanta.

[104]  B. P. Lim,et al.  Flow injection determination of anisidine value in palm oil samples using a triiodide potentiometric detector. , 2007, Analytica chimica acta.

[105]  H. Poppe,et al.  A possible approach to the optimization of flow injectin analysis , 1983 .

[106]  J. W. Hofstraat,et al.  Fluidized-bed solid-phase extraction: A novel approach to time-integrated sampling of trace metals in surface water , 1991 .

[107]  Erno Pungor,et al.  Theoretical Backgrounds of Flow Analysis , 1987 .

[108]  S. Kolev,et al.  Mathematical modeling of single-line flow-injection analysis systems without chemical reaction , 1988 .

[109]  J. Ruzicka.  Lab-on-valve: universal microflow analyzer based on sequential and bead injection , 2000 .

[110]  E. Zagatto,et al.  Recording the real sample distribution and concentration/time functions in flow injection analysis , 1987 .

[111]  J. Ruzicka,et al.  Stopped flow and merging zones — a new approach to enzymatic assay by flow injection analysis , 1979 .

[112]  J. Tyson.  Analytical information from doublet peaks in flow injection analysis. Part I. Basic equation and applications to flow injection titrations , 1987 .

[113]  F. Krug,et al.  Merging zones in flow injection analysis: Part 3. Spectrophotometric determination of aluminium in plant and soil materials with sequential addition of pulsed reagents , 1979 .

[114]  G. Christian,et al.  Chemical kinetics with reagent dispersion in single-line flow-injection systems , 1987 .

[115]  B. Reis,et al.  Detecting and circumventing sources of inaccuracy in flow analysis , 2001 .

[116]  B. Fields,et al.  Kinetic treatment of unsegmented flow systems : Part 1. Subjective and semiquantitative evaluations of flow-injection systems with gradient chamber , 1981 .

[117]  Ricardo S. Honorato,et al.  A flow-batch titrator exploiting a one-dimensional optimisation algorithm for end point search , 1999 .

[118]  K. Stewart,et al.  Exponential dilution chambers for scale expansion in flow injection analysis , 1982 .

[119]  O. Levenspiel.  Chemical Reaction Engineering , 1972 .

[120]  L. Gouveia,et al.  Binary search in flow titration employing photometric end-point detection , 1995 .

[121]  J. Chen,et al.  The hydrodynamic behavior of the liquid-solid circulating fluidized bed ion exchange system for cesium removal , 2003 .

[122]  P. Fielden,et al.  Flow injection analysis , 1975 .

[123]  Gary D. Christian,et al.  Variable flow rates and a sinusoidal flow pump for flow injection analysis , 1990 .

[124]  R. Barnes,et al.  On-line dilution, steady-state concentrations for inductively coupled plasma atomic emission and mass spectrometry achieved by tandem injection and merging-stream flow injection , 1989 .

[125]  J. Ruzicka,et al.  Flow injection analysis : Part IX. A New Approach to Continuous Flow Titrations , 1977 .

[126]  J. Janata,et al.  Heterogeneous samples in flow-injection systems , 1985 .

[127]  I. Raimundo.  Automated Monosegmented Flow Analyser. Determination of Glucose, Creatinine and Urea , 1997 .