Breast Density Classification with Convolutional Neural Networks

Breast Density Classification is a problem in Medical Imaging domain that aims to assign an American College of Radiology’s BIRADS category (I-IV) to a mammogram as an indication of tissue density. This is performed by radiologists in an qualitative way, and thus subject to variations from one physician to the other. In machine learning terms it is a 4-ordered-classes classification task with highly unbalance training data, as classes are not equally distributed among populations, even with variations among ethnicities. Deep Learning techniques in general became the state-of-the-art for many imaging classification tasks, however, dependent on the availability of large datasets. This is not often the case for Medical Imaging, and thus we explore Transfer Learning and Dataset Augmentationn. Results show a very high squared weighted kappa score of 0.81 (0.95 C.I. [0.77,0.85]) which is high in comparison to the 8 medical doctors that participated in the dataset labeling 0.82 (0.95 CI [0.77, 0.87]).

[1]  Benjamin Castaneda,et al.  Characterization of breast density in women from Lima, Peru , 2015, Medical Imaging.

[2]  Nicolas Pinto,et al.  Beyond simple features: A large-scale feature search approach to unconstrained face recognition , 2011, Face and Gesture 2011.

[3]  N. Boyd,et al.  Mammographic density and breast cancer risk: current understanding and future prospects , 2011, Breast Cancer Research.

[4]  David D. Cox,et al.  A High-Throughput Screening Approach to Discovering Good Forms of Biologically Inspired Visual Representation , 2009, PLoS Comput. Biol..

[5]  X. Castells,et al.  Inter- and intraradiologist variability in the BI-RADS assessment and breast density categories for screening mammograms. , 2012, The British journal of radiology.

[6]  Robert Marti,et al.  A Comparison of Breast Tissue Classification Techniques , 2006, MICCAI.

[7]  Susan M. Astley,et al.  Local mammographic density as a predictor of breast cancer , 2015, Medical Imaging.

[8]  Joseph Pinto,et al.  Experimental assessment of an automatic breast density classification algorithm based on principal component analysis applied to histogram data , 2015, Other Conferences.

[9]  Robert Marti,et al.  A Novel Breast Tissue Density Classification Methodology , 2008, IEEE Transactions on Information Technology in Biomedicine.

[10]  Jacques Wainer,et al.  Automatic breast density classification using a convolutional neural network architecture search procedure , 2015, Medical Imaging.

[11]  J. R. Landis,et al.  The measurement of observer agreement for categorical data. , 1977, Biometrics.

[12]  Geoffrey E. Hinton,et al.  ImageNet classification with deep convolutional neural networks , 2012, Commun. ACM.

[13]  Trevor Darrell,et al.  Caffe: Convolutional Architecture for Fast Feature Embedding , 2014, ACM Multimedia.

[14]  Celia MT Greenwood,et al.  A genome-wide linkage study of mammographic density, a risk factor for breast cancer , 2011, Breast Cancer Research.

[15]  Giske Ursin,et al.  Mammographic density - a useful biomarker for breast cancer risk in epidemiologic studies , 2009 .

[16]  J. Wolfe Risk for breast cancer development determined by mammographic parenchymal pattern , 1976, Cancer.