The problem of magnesium deficiency and metabolic syndrome

The epidemic of obesity, insulin resistance and diabetes mellitus currently observed in developed countries requires new approaches to the prevention and treatment. Besides the hypercaloric diet micronutrient deficiency is involved in the development of metabolic disorders. Recent diet changes due to the agrarian and food technological revolutions has led to the emergence of new micronutrient deficiencies, primarily magnesium. While its hypotonic action is well studied, magnesium’s positive effects on metabolism, anti-inflammatory and antioxidant effects are currently the focus of researchers’ attention. The magnesium preparations reduce insulin resistance, improves anthropometric and laboratory markers of the metabolic syndrome. Detection of magnesium deficiency, including subclinical one, and correction of magnesium status are important tasks for the prevention and complex therapy of the metabolic syndrome. Given the higher bioavailability and lower incidence of side effects, organic magnesium salts are preferable.

[1]  C. Tack,et al.  Hypomagnesemia and Cardiovascular Risk in Type 2 Diabetes , 2022, Endocrine reviews.

[2]  P. Bogdański,et al.  The Role of Magnesium in the Pathogenesis of Metabolic Disorders , 2022, Nutrients.

[3]  O. Kytikova,et al.  Prevalence and biomarkers in metabolic syndrome , 2021, Obesity and metabolism.

[4]  R. Costello,et al.  Effectively Prescribing Oral Magnesium Therapy for Hypertension: A Categorized Systematic Review of 49 Clinical Trials , 2021, Nutrients.

[5]  Alireza Jafari,et al.  The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trials , 2020, Critical reviews in food science and nutrition.

[6]  Yiping Wei,et al.  Association of magnesium consumption with type 2 diabetes and glucose metabolism: A systematic review and pooled study with trial sequential analysis , 2019, Diabetes/metabolism research and reviews.

[7]  F. Bellone,et al.  Magnesium disorders: Myth or facts? , 2019, European journal of internal medicine.

[8]  K. Kostov Effects of Magnesium Deficiency on Mechanisms of Insulin Resistance in Type 2 Diabetes: Focusing on the Processes of Insulin Secretion and Signaling , 2019, International journal of molecular sciences.

[9]  A. Ismail,et al.  Chronic magnesium deficiency and human disease; time for reappraisal? , 2018, QJM : monthly journal of the Association of Physicians.

[10]  Andrea M P Romani Beneficial Role of Mg2+ in Prevention and Treatment of Hypertension , 2018, International journal of hypertension.

[11]  M. M. Joosten,et al.  Magnesium and Blood Pressure: A Physiology-Based Approach. , 2018, Advances in chronic kidney disease.

[12]  A. Sahebkar,et al.  Effect of Magnesium Supplementation on Plasma C-reactive Protein Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. , 2017, Current pharmaceutical design.

[13]  X. Fang,et al.  Dose-response relationship between dietary magnesium intake, serum magnesium concentration and risk of hypertension: a systematic review and meta-analysis of prospective cohort studies , 2017, Nutrition Journal.

[14]  M. Rodríguez-Moran,et al.  Magnesium in metabolic syndrome: a review based on randomized, double-blind clinical trials. , 2016, Magnesium research.

[15]  A. Folsom,et al.  Serum and dietary magnesium and the risk for type 2 diabetes mellitus: the Atherosclerosis Risk in Communities Study. , 1999, Archives of internal medicine.