Deformable and durable phantoms with controlled density of scatterers

We have developed deformable and durable optical tissue phantoms with a simple and well-defined microstructure including a novel combination of scatterers and a matrix material. These were developed for speckle and elastography investigations in optical coherence tomography, but should prove useful in many other fields. We present in detail the fabrication process which involves embedding silica microspheres in a silicone matrix. We also characterize the resulting phantoms with scanning electron microscopy and optical measurements. To our knowledge, no such phantoms were proposed in the literature before. Our technique has a wide range of applicability and could also be adapted to fabricate phantoms with various optical and mechanical properties.

[1]  N. Ghosh,et al.  Depolarization of light in tissue phantoms - effect of a distribution in the size of scatterers. , 2003, Optics express.

[2]  G. Lamouche,et al.  On the speckle size in optical coherence tomography , 2008, SPIE BiOS.

[3]  Yingcai Long,et al.  Investigation of poly(dimethyl siloxane) (PDMS)–solvent interactions by DSC , 2000 .

[4]  D. Delpy,et al.  A design for a stable and reproducible phantom for use in near infra-red imaging and spectroscopy , 1993 .

[5]  V. Tuchin.  Tissue Optics: Light Scattering Methods and Instruments for Medical Diagnosis , 2000 .

[6]  J. Goodman.  Speckle Phenomena in Optics: Theory and Applications , 2020 .

[7]  R Marchesini,et al.  A phantom with tissue‐like optical properties in the visible and near infrared for use in photomedicine , 2001, Lasers in surgery and medicine.

[8]  Bernard Gelebart,et al.  Phase function simulation in tissue phantoms: a fractal approach , 1996 .

[9]  David Huang,et al.  Handbook of optical coherence tomography. , 2003, Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye.

[10]  Guy Lamouche,et al.  LOW-COHERENCE INTERFEROMETRY, AN ADVANCED TECHNIQUE FOR OPTICAL METROLOGY IN INDUSTRY , 2004 .

[11]  David D Sampson,et al.  Correlation of static speckle with sample properties in optical coherence tomography. , 2006, Optics letters.

[12]  A. Rück,et al.  Design and Characterisation of a Tissue Phantom System for Optical Diagnostics , 1998, Lasers in Medical Science.

[13]  H. Rinneberg,et al.  Preparation of solid phantoms with defined scattering and absorption properties for optical tomography. , 1996, Physics in medicine and biology.

[14]  Brian W. Pogue,et al.  Near-infrared breast tomography calibration with optoelastic tissue simulating phantoms , 2003, J. Electronic Imaging.

[15]  D. Delpy,et al.  An improved design for a stable and reproducible phantom material for use in near-infrared spectroscopy and imaging. , 1995, Physics in medicine and biology.

[16]  Joseph M. Schmitt,et al.  MODEL OF OPTICAL COHERENCE TOMOGRAPHY OF HETEROGENEOUS TISSUE , 1997 .

[17]  T. Tkaczyk,et al.  Texture analysis of optical coherence tomography images: feasibility for tissue classification. , 2003, Journal of biomedical optics.

[18]  B. Pogue,et al.  Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry. , 2006, Journal of biomedical optics.

[19]  Stuart K Williams,et al.  Texture analysis of speckle in optical coherence tomography images of tissue phantoms. , 2006, Physics in medicine and biology.

[20]  S. Kohjiya,et al.  Chemical modification of silicone elastomers for optics , 1990 .