- An efficient synthesis of new 6-pyridinylaminopurines was developed based on Buchwald-Hartwig coupling reaction between aminopyridines and 2,6-dichloro-9-iso-propylpurine. The reaction was best carried out in the presence of a limited load of palladium acetate (4 %) as catalyst, racemic 2,2'-bis(diphenylphosphanyl)-l,l'-binaphtyl (8 %) as ligand and potassium tert-butoxide as base. Rising the load of catalyst, or using other catalysts and bases led to the development of side reactions.