Metal-binding sites in proteins.

A dramatic increase in the number of solved metalloprotein structures and recent breakthroughs in structural analysis have provided a sufficiently detailed understanding of the structural chemistry of some metal-binding sites to allow successful design. As a result, metal-binding site design is now one of the most powerful and promising approaches for influencing protein folding, assembly, stability and catalysis.

[1]  D. Matthews,et al.  Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase. , 1991, Science.

[2]  R. Fletterick,et al.  Regulation of serine protease activity by an engineered metal switch. , 1990, Biochemistry.

[3]  M. Gelb,et al.  Crystal structure of bee-venom phospholipase A2 in a complex with a transition-state analogue , 1990, Science.

[4]  P. Chakrabarti.  Systematics in the interaction of metal ions with the main-chain carbonyl group in protein structures. , 1990, Biochemistry.

[5]  J. Ibers,et al.  Modeling coordination sites in metallobiomolecules. , 1980, Science.

[6]  Hausinger Rp.  Mechanisms of metal ion incorporation into metalloproteins. , 1990 .

[7]  P. Chakrabarti,et al.  Geometry of interaction of metal ions with histidine residues in protein structures. , 1990, Protein engineering.

[8]  S. Sligar,et al.  Discrimination between oxygen and carbon monoxide and inhibition of autooxidation by myoglobin. Site-directed mutagenesis of the distal histidine. , 1989, The Journal of biological chemistry.

[9]  P E Wright,et al.  Three-dimensional solution structure of a single zinc finger DNA-binding domain. , 1989, Science.

[10]  W. Lipscomb,et al.  Crystal structure of fructose-1,6-bisphosphatase complexed with fructose 6-phosphate, AMP, and magnesium. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[11]  M. McPherson,et al.  Novel thioether bond revealed by a 1.7 Å crystal structure of galactose oxidase , 1994, Nature.

[12]  M. Summers,et al.  High-resolution structure of an HIV zinc fingerlike domain via a new NMR-based distance geometry approach. , 1990, Biochemistry.

[13]  J. Berg.  Zinc finger domains: hypotheses and current knowledge. , 1990, Annual review of biophysics and biophysical chemistry.

[14]  M Ikehara,et al.  Design and creation of a Ca2+ binding site in human lysozyme to enhance structural stability. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[15]  R J Fletterick,et al.  Engineered metalloregulation in enzymes. , 1992, Trends in biochemical sciences.

[16]  D. Christianson,et al.  Another catalytic triad? , 1990, Nature.

[17]  John A. Tainer,et al.  Protein metal-binding sites. , 1992 .

[18]  W. Lipscomb,et al.  Crystal structure of the complex of carboxypeptidase A with a strongly bound phosphonate in a new crystalline form: comparison with structures of other complexes. , 1990, Biochemistry.

[19]  G A Petsko,et al.  The structure of iron superoxide dismutase from Pseudomonas ovalis complexed with the inhibitor azide. , 1990, Protein engineering.

[20]  J. Tainer,et al.  Visualization of molecular flexibility and its effects on electrostatic recognition. , 1990, Journal of molecular graphics.

[21]  R. Lerner,et al.  Synthesis and characterization of a recombinant myohemerythrin protein encoded by a synthetic gene. , 1991, Gene.

[22]  K. Yamamoto,et al.  Solution structure of the glucocorticoid receptor DNA-binding domain. , 1990, Science.

[23]  W. Lipscomb,et al.  Binding of substrate CO2 to the active site of human carbonic anhydrase II: a molecular dynamics study. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[24]  B. Vallee,et al.  Zinc coordination, function, and structure of zinc enzymes and other proteins. , 1990, Biochemistry.

[25]  D E Koshland,et al.  Regulation of an enzyme by phosphorylation at the active site. , 1991, Science.

[26]  Robert J.P. Williams,et al.  The symbiosis of metal and protein functions , 1985 .

[27]  J. Richardson,et al.  Determination and analysis of the 2 A-structure of copper, zinc superoxide dismutase. , 1980, Journal of molecular biology.

[28]  D. Kurtz.  Oxo- and hydroxo-bridged diiron complexes: a chemical perspective on a biological unit , 1990 .

[29]  R. Huber,et al.  X-ray crystal structure of the blue oxidase ascorbate oxidase from zucchini. Analysis of the polypeptide fold and a model of the copper sites and ligands. , 1989, Journal of molecular biology.

[30]  J. Tainer,et al.  Enzyme motifs in antibodies , 1990, Nature.

[31]  P. Tomlinson,et al.  Book reviews , 2008, Brittonia.

[32]  R. Hodges,et al.  Calcium-induced peptide association to form an intact protein domain: 1H NMR structural evidence. , 1990, Science.

[33]  W G Hol,et al.  Crystal structure of hexameric haemocyanin from Panulirus interruptus refined at 3.2 A resolution. , 1994, Journal of molecular biology.

[34]  J. Tainer,et al.  Evolution of CuZn superoxide dismutase and the Greek Key β‐barrel structural motif , 1989, Proteins.

[35]  C. Cambillau,et al.  Three‐Dimensionnal structures of complexes of Lathyrus ochrus isolectin I with glucose and mannose: Fine specificity of the monosaccharide‐binding site , 1994, Proteins: Structure, Function, and Bioinformatics.

[36]  E T Adman,et al.  Copper protein structures. , 1991, Advances in protein chemistry.

[37]  P. Chakrabarti,et al.  Interaction of metal ions with carboxylic and carboxamide groups in protein structures. , 1990, Protein engineering.

[38]  A J Olson,et al.  Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c. , 1991, The Journal of biological chemistry.

[39]  D Eisenberg,et al.  Where metal ions bind in proteins. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[40]  D B Goodin,et al.  Identification by ENDOR of Trp191 as the free-radical site in cytochrome c peroxidase compound ES. , 1989, Science.

[41]  F. Arnold,et al.  Characterization of His-X3-His sites in α-helices of synthetic metal-binding bovine somatotropin , 1991 .

[42]  D. Christianson,et al.  Structural biology of zinc. , 1991, Advances in protein chemistry.

[43]  J. Lehn,et al.  DNH deoxyribonucleohelicates: self assembly of oligonucleosidic double-helical metal complexes , 1990, Nature.

[44]  John A. Tainer,et al.  Structure and mechanism of copper, zinc superoxide dismutase , 1983, Nature.

[45]  Hans Eklund,et al.  Three-dimensional structure of the free radical protein of ribonucleotide reductase , 1990, Nature.

[46]  J. W. Campbell,et al.  Calcium binding sites in tomato bushy stunt virus visualized by Laue crystallography. , 1990, Journal of molecular biology.

[47]  W. H. Armstrong.  Metalloprotein Crystallography Survey of Recent Results and Relationships to Model Studies , 1988 .

[48]  William F. DeGrado,et al.  De novo design of a Zn2+-binding protein , 1990 .

[49]  J. Tainer,et al.  Changes in crystallographic structure and thermostability of a Cu,Zn superoxide dismutase mutant resulting from the removal of a buried cysteine. , 1993, The Journal of biological chemistry.

[50]  L Regan,et al.  A tetrahedral zinc(II)-binding site introduced into a designed protein. , 1990, Biochemistry.