Cardioprotection by gene therapy: A review paper on behalf of the Working Group on Drug Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology.

[1]  M. Mayr,et al.  Functional Genomics of Cardioprotection by Ischemic Conditioning and the Influence of Comorbid Conditions: Implications in Target Identification. , 2015, Current drug targets.

[2]  P. Pagliaro,et al.  Redox signalling and cardioprotection: translatability and mechanism , 2015, British journal of pharmacology.

[3]  J. Sluijter,et al.  Novel therapeutic strategies for cardioprotection. , 2014, Pharmacology & therapeutics.

[4]  P. Ferdinandy,et al.  Interaction of Risk Factors, Comorbidities, and Comedications with Ischemia/Reperfusion Injury and Cardioprotection by Preconditioning, Postconditioning, and Remote Conditioning , 2014, Pharmacological Reviews.

[5]  Joseph C. Wu,et al.  Cross Talk of Combined Gene and Cell Therapy in Ischemic Heart Disease: Role of Exosomal MicroRNA Transfer , 2014, Circulation.

[6]  P. Ferdinandy,et al.  MicroRNAs associated with ischemia-reperfusion injury and cardioprotection by ischemic pre- and postconditioning: protectomiRs. , 2014, American journal of physiology. Heart and circulatory physiology.

[7]  Z. Giricz,et al.  Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles. , 2014, Journal of molecular and cellular cardiology.

[8]  P. Ferdinandy,et al.  Ischemic postconditioning alters the gene expression pattern of the ischemic heart , 2014, Experimental biology and medicine.

[9]  L. V. Van Laake,et al.  Translating cardioprotection for patient benefit: position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology. , 2013, Cardiovascular research.

[10]  T. Libermann,et al.  Microarray and proteomic analysis of the cardioprotective effects of cold blood cardioplegia in the mature and aged male and female. , 2012, Physiological genomics.

[11]  R. Schilling,et al.  Current Genomics in Cardiovascular Medicine , 2012, Current genomics.

[12]  Jin Han,et al.  Identification of potential target genes of cardioprotection against ischemia-reperfusion injury by express sequence tags analysis in rat hearts. , 2012, Journal of cardiology.

[13]  Z. Giricz,et al.  Autophagy, Myocardial Protection, and the Metabolic Syndrome , 2012, Journal of cardiovascular pharmacology.

[14]  F. Roubille,et al.  Down-regulation of the transcription factor ZAC1 upon pre- and postconditioning protects against I/R injury in the mouse myocardium. , 2012, Cardiovascular research.

[15]  R. de Caterina,et al.  Hepatocyte growth factor: Molecular biomarker and player in cardioprotection and cardiovascular regeneration , 2012, Thrombosis and Haemostasis.

[16]  R. Madonna,et al.  Cell-Based Gene Therapies and Stem Cells for Regeneration of Ischemic Tissues , 2011 .

[17]  N. Chen,et al.  Gene transfer as a strategy to achieve permanent cardioprotection I: rAAV-mediated gene therapy with inducible nitric oxide synthase limits infarct size 1 year later without adverse functional consequences , 2011, Basic Research in Cardiology.

[18]  Z. Giricz,et al.  Role of iNOS and peroxynitrite-matrix metalloproteinase-2 signaling in myocardial late preconditioning in rats. , 2010, American journal of physiology. Heart and circulatory physiology.

[19]  Z. Giricz,et al.  Autophagy Induced by Ischemic Preconditioning is Essential for Cardioprotection , 2010, Journal of cardiovascular translational research.

[20]  J. Egido,et al.  Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis. , 2010, Cardiovascular research.

[21]  R. Bolli,et al.  Hepatocyte growth factor/Met gene transfer in cardiac stem cells—potential for cardiac repair , 2010, Basic Research in Cardiology.

[22]  M. Siddiqui,et al.  Signaling networks regulating cardiac myocyte survival and death. , 2009, Current opinion in investigational drugs.

[23]  F. McGowan,et al.  Transcriptomic and proteomic analysis of global ischemia and cardioprotection in the rabbit heart. , 2009, Physiological genomics.

[24]  J. Mehta,et al.  Overexpression of TGFβ1 by adeno-associated virus type-2 vector protects myocardium from ischemia–reperfusion injury , 2008, Gene Therapy.

[25]  P. Ferdinandy,et al.  Interaction of Cardiovascular Risk Factors with Myocardial Ischemia/Reperfusion Injury, Preconditioning, and Postconditioning , 2007, Pharmacological Reviews.

[26]  M. Arai,et al.  In vivo hepatocyte growth factor gene transfer reduces myocardial ischemia-reperfusion injury through its multiple actions. , 2007, Journal of cardiac failure.

[27]  H. Duan,et al.  Adenoviral gene transfer of sphingosine kinase 1 protects heart against ischemia/reperfusion-induced injury and attenuates its postischemic failure. , 2007, Human gene therapy.

[28]  K. Brunt,et al.  Preemptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function 1 yr after acute myocardial infarction. , 2007, American journal of physiology. Heart and circulatory physiology.

[29]  N. Nagy,et al.  Protection against myocardial ischemia-reperfusion injury by the angiogenic Masterswitch protein PR 39 gene therapy: the roles of HIF1alpha stabilization and FGFR1 signaling. , 2007, Antioxidants & redox signaling.

[30]  K. Fukuda,et al.  G-CSF and HGF: combination of vasculogenesis and angiogenesis synergistically improves recovery in murine hind limb ischemia. , 2007, Journal of molecular and cellular cardiology.

[31]  K. Fukunaga,et al.  Inhibition of HtrA2/Omi ameliorates heart dysfunction following ischemia/reperfusion injury in rat heart in vivo. , 2007, European journal of pharmacology.

[32]  B. Gloss,et al.  In vivo gene delivery of HSP70i by adenovirus and adeno-associated virus preserves contractile function in mouse heart following ischemia-reperfusion. , 2006, American journal of physiology. Heart and circulatory physiology.

[33]  M. Shakibaei,et al.  Mechanisms of apoptosis after ischemia and reperfusion: Role of the renin-angiotensin system , 2006, Apoptosis.

[34]  S. Solomon,et al.  Chronic recurrent myocardial ischemic injury is significantly attenuated by pre-emptive adeno-associated virus heme oxygenase-1 gene delivery. , 2006, Journal of the American College of Cardiology.

[35]  M. Gnecchi,et al.  Heme oxygenase‐1 (HO‐1) inhibits postmyocardial infarct remodeling and restores ventricular function , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[36]  R. Bolli,et al.  Gene therapy with iNOS provides long-term protection against myocardial infarction without adverse functional consequences. , 2006, American journal of physiology. Heart and circulatory physiology.

[37]  P. Csermely,et al.  Heat shock proteins as emerging therapeutic targets , 2005, British journal of pharmacology.

[38]  Y. Tang,et al.  A Vigilant, Hypoxia-Regulated Heme Oxygenase-1 Gene Vector in the Heart Limits Cardiac Injury After Ischemia-Reperfusion In Vivo , 2005, Journal of cardiovascular pharmacology and therapeutics.

[39]  L. Argaud,et al.  Fas-independent mitochondrial damage triggers cardiomyocyte death after ischemia-reperfusion. , 2005, American journal of physiology. Heart and circulatory physiology.

[40]  Seng H. Cheng,et al.  Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury. , 2005, American journal of physiology. Cell physiology.

[41]  S. Ogawa,et al.  Powerful and controllable angiogenesis by using gene-modified cells expressing human hepatocyte growth factor and thymidine kinase. , 2004, Journal of the American College of Cardiology.

[42]  Z. Oltvai,et al.  Network biology: understanding the cell's functional organization , 2004, Nature Reviews Genetics.

[43]  W. Birchmeier,et al.  Met, metastasis, motility and more , 2003, Nature Reviews Molecular Cell Biology.

[44]  H. Hamada,et al.  Bcl-xL gene transfer protects the heart against ischemia/reperfusion injury. , 2003, Biochemical and biophysical research communications.

[45]  J. Lee.  What was genomics? , 2003, The Lancet. Oncology.

[46]  R. Kloner,et al.  Brief episode of ischemia activates protective genetic program in rat heart: a gene chip study. , 2003, Cardiovascular research.

[47]  Y. Ahn,et al.  Strategic advantages of insulin‐like growth factor‐I expression for cardioprotection , 2003, The journal of gene medicine.

[48]  P. Ferdinandy,et al.  Effect of classic preconditioning on the gene expression pattern of rat hearts: a DNA microarray study , 2003, FEBS letters.

[49]  L. Kedes,et al.  Gene activity changes in ischemically preconditioned rabbit heart gene: discovery array study. , 2002, Heart disease.

[50]  M. Goldberg,et al.  Gene expression profiles in human cardiac cells subjected to hypoxia or expressing a hybrid form of HIF-1α , 2002 .

[51]  J. Oyama,et al.  Gene Therapy Strategy for Long-Term Myocardial Protection Using Adeno-Associated Virus-Mediated Delivery of Heme Oxygenase Gene , 2002, Circulation.

[52]  J. Isner,et al.  Genetic targeting for cardiovascular therapeutics: are we near the summit or just beginning the climb? , 2001, Physiological genomics.

[53]  R. Bolli.  Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research. , 2001, Journal of molecular and cellular cardiology.

[54]  M. Amrani,et al.  Heat Shock Protein 70 Gene Transfection Protects Mitochondrial and Ventricular Function Against Ischemia-Reperfusion Injury , 2001, Circulation.

[55]  J. Mehta,et al.  TGF-beta(1) modulates NOS expression and phosphorylation of Akt/PKB in rat myocytes exposed to hypoxia-reoxygenation. , 2001, American journal of physiology. Heart and circulatory physiology.

[56]  P. Ferdinandy,et al.  Delayed preconditioning of myocardium: current perspectives , 2001, Basic Research in Cardiology.

[57]  B. A. French,et al.  Gene Therapy With Extracellular Superoxide Dismutase Protects Conscious Rabbits Against Myocardial Infarction , 2001, Circulation.

[58]  M. Hess,et al.  Gene Transfer of Heat-Shock Protein 70 Reduces Infarct Size In Vivo After Ischemia/Reperfusion in the Rabbit Heart , 2001, Circulation.

[59]  K. Matsumoto,et al.  Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF. , 2000, The Journal of clinical investigation.

[60]  R. Bolli,et al.  The Late Phase of Preconditioning , 2000, Circulation research.

[61]  J. Lammers,et al.  Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1 , 2000, Current Biology.

[62]  Y. Taniyama,et al.  Potential contribution of a novel antifibrotic factor, hepatocyte growth factor, to prevention of myocardial fibrosis by angiotensin II blockade in cardiomyopathic hamsters. , 2000, Circulation.

[63]  J. Mehta,et al.  Hypoxia-reoxygenation-induced apoptosis in cultured adult rat myocytes and the protective effect of platelets and transforming growth factor-beta(1). , 1999, The Journal of pharmacology and experimental therapeutics.

[64]  Y. Kaneda,et al.  Myocardial protection with endogenous overexpression of manganese superoxide dismutase. , 1999, The Annals of thoracic surgery.

[65]  P. Ping,et al.  The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[66]  K. Matsumoto,et al.  Gene transfection of hepatocyte growth factor attenuates reperfusion injury in the heart. , 1999, The Annals of thoracic surgery.

[67]  R. Bolli,et al.  Nitric oxide synthase is the mediator of late preconditioning against myocardial infarction in conscious rabbits. , 1998, Circulation.

[68]  R. Bolli,et al.  The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase. Evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning. , 1997, Circulation research.

[69]  Y. Kaneda,et al.  [In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat]. , 1997, Journal of cardiology.

[70]  A. M. Lefer,et al.  Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[71]  R. Bolli,et al.  Demonstration of free radical generation in the "stunned" myocardium in the conscious dog and identification of major differences between conscious and open-chest dogs. , 1993, The Journal of clinical investigation.

[72]  M. Hori,et al.  Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia. , 1993, Circulation research.

[73]  R. Bolli.  Preconditioning: a paradigm shift in the biology of myocardial ischemia. , 2007, American journal of physiology. Heart and circulatory physiology.

[74]  D. Yellon,et al.  Myocardial Infarction , 2005 .

[75]  P. Carmeliet,et al.  PR39, a peptide regulator of angiogenesis , 2000, Nature Medicine.

[76]  M. Bond,et al.  Differential distribution of 70-kD heat shock protein in atherosclerosis. Its potential role in arterial SMC survival. , 1995, Arteriosclerosis, thrombosis, and vascular biology.