Effects of mild physical exercise on serum lipoproteins and metabolites of arachidonic acid: a controlled randomised trial in middle aged men.

To study the effects of physical exercise on biochemical risk factors for ischaemic heart disease 31 healthy middle aged men undertook regular physical exercise for two months and 29 served as controls in a randomised trial. In the men taking regular exercise serum cholesterol concentrations increased 26% more in the high density lipoprotein subfraction two (HDL2) and decreased 31% more in the subfraction three (HDL3) and 9% more in the low density lipoprotein fraction than in the control group. A tendency towards increased plasma 6-keto-prostaglandin F1 alpha concentration and decreased serum thromboxane B2 concentration was found during the period of regular exercise, but prostaglandin E2 concentrations remained unchanged. The increase in plasma 6-keto-prostaglandin F1 alpha concentration was associated with an increase in serum HDL2 cholesterol concentration in the group taking regular exercise. Our data suggest that mild regular physical exercise favourably influences cholesterol distribution in serum lipoproteins in healthy middle aged men and may have beneficial effects on circulating metabolites of arachidonic acid.

[1]  C. Dollery,et al.  RELEASE OF PROSTACYCLIN IN VIVO AND ITS ROLE IN MAN , 1983, The Lancet.

[2]  W. Förster.  Interactions Between Lipoproteins and PGI2 Under Physiologic and Pathophysiologic Conditions , 1983 .

[3]  T. Nikkari,et al.  Exercise and Arachidonic Acid Metabolites: Effect of Adrenergic Beta Blockade , 1983 .

[4]  R. Krauss,et al.  Increased exercise level and plasma lipoprotein concentrations: a one-year, randomized, controlled study in sedentary, middle-aged men. , 1983, Metabolism: clinical and experimental.

[5]  M. Peterson,et al.  THROMBOXANE AND PROSTACYCLIN (EPOPROSTENOL) DURING EXERCISE IN DIFFUSE PULMONARY FIBROSIS , 1982, The Lancet.

[6]  P. Puska,et al.  Effect of diet on serum lipoproteins in a population with a high risk of coronary heart disease. , 1982, The New England journal of medicine.

[7]  A. Tall,et al.  Stimulation of arterial endothelial cell prostacyclin synthesis by high density lipoproteins. , 1982, The Journal of biological chemistry.

[8]  J. Salonen,et al.  Physical activity and risk of myocardial infarction, cerebral stroke and death: a longitudinal study in Eastern Finland. , 1982, American journal of epidemiology.

[9]  P. Kirstein,et al.  Determination of the cholesterol content of high density lipoprotein subfractions HDL2 and HDL3, without contamination of Lp(a), in human plasma. , 1981, Clinica chimica acta; international journal of clinical chemistry.

[10]  R. Santen,et al.  Effect of prolonged exercise on plasma prostaglandin levels. , 1981, Prostaglandins and medicine.

[11]  O. Burghuber,et al.  Decreased prostacyclin sensitivity of human platelets after jogging and squash. , 1981, Prostaglandins and medicine.

[12]  A. Szczeklik,et al.  Low density lipoproteins (LDL) are carriers for lipid peroxides and inhibit prostacyclin (PGI2) biosynthesis in arteries. , 1980, Artery.

[13]  R. Rauramaa,et al.  Effect of moderate physical exercise on serum lipoproteins. A controlled clinical trial with special reference to serum high-density lipoproteins. , 1979, Circulation.

[14]  H. Sinzinger,et al.  PROSTACYCLIN GENERATION IN ATHEROSCLEROTIC ARTERIES , 1979, The Lancet.

[15]  S Moncada,et al.  Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls. , 1979, The New England journal of medicine.

[16]  J. Hoak,et al.  Lipoproteins and the Inhibitory Effect of Human Endothelial Cells on Platelet Function , 1978, Circulation research.

[17]  D. Thelle,et al.  THE TROMSØHEART-STUDY HIGH-DENSITY LIPOPROTEIN AND CORONARY HEART-DISEASE: A PROSPECTIVE CASE-CONTROL STUDY , 1977, The Lancet.

[18]  N. Nie.  SPSS: statistical package for the social sciences , 1975 .

[19]  B. Jaffe,et al.  Methods of Hormone Radioimmunoassay , 1974 .

[20]  S. Chave,et al.  Vigorous exercise in leisure-time and the incidence of coronary heart-disease. , 1973, Lancet.

[21]  K. Carlson.  Lipoprotein fractionation. , 1973, Journal of clinical pathology. Supplement.

[22]  J. Albers,et al.  Human serum lipoproteins. Evidence for three classes of lipoproteins in S fO-2. , 1972, Biochemistry.

[23]  N. Nie,et al.  Statistical Package for the Social Sciences , 1970 .

[24]  R. Morfin,et al.  Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. , 1970, Journal of lipid research.

[25]  W Young,et al.  Ischemic Heart Disease, Atherosclerosis, and Longevity , 1966, Circulation.