GEOGRAPHICALLY LOCALIZED KNOWLEDGE: SPILLOVERS OR MARKETS?

Using detailed data on California biotechnology, the authors find that the positive impact of research universities on nearby firms relates to identifiable market exchange between particular university star scientists and firms and not to generalized knowledge spillovers. Poisson and two-stage Beckman regressions indicate the number of star-firm collaborations powerfully predicts success: for an average firm, five articles coauthored by academic stars and the firm's scientists imply about five more products in development, 3.5 more products on the market, and 860 more employees. Stars collaborating with or employed by firms, or who patent, have significantly higher citation rates than pure academic stars. Copyright 1998 by Oxford University Press.

[1]  R. Nelson,et al.  Factors behind cross-industry differences in technical progress , 1997 .

[2]  Larry Samuelson,et al.  The Growth and Failure of U. S. Manufacturing Plants , 1989 .

[3]  Ronald H. Coase,et al.  The Lighthouse in Economics , 1974, The Journal of Law and Economics.

[4]  Elhanan Helpman,et al.  International R&D spillovers , 1995 .

[5]  M.B. Lieberman,et al.  A literature citation study of science-technology coupling in electronics , 1978, Proceedings of the IEEE.

[6]  L. Zucker,et al.  Star scientists and institutional transformation: patterns of invention and innovation in the formation of the biotechnology industry. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[7]  Jeffrey M. Wooldridge,et al.  On the application of robust, regression- based diagnostics to models of conditional means and conditional variances , 1991 .

[8]  Richard R. Nelson,et al.  On the Sources and Significance of Interindustry Differences in Technological Opportunities , 1995 .

[9]  Michael R. Darby,et al.  Present at the Revolution: Transformation of Technical Identity for a Large Incumbent Pharmaceutical Firm after the Biotechnological Breakthrough , 1995 .

[10]  H. Zuckerman Nobel laureates in science: patterns of productivity, collaboration, and authorship. , 1967, American sociological review.

[11]  A. Cameron,et al.  Regression-based tests for overdispersion in the Poisson model☆ , 1990 .

[12]  Z. Griliches Patent Statistics as Economic Indicators: a Survey , 1990 .

[13]  B. Jones,et al.  Higher Education Policies and Economic Growth in the American States , 1988 .

[14]  S. Winter,et al.  An evolutionary theory of economic change , 1983 .

[15]  Josh Lerner,et al.  Venture Capitalists and the Oversight of Private Firms , 1995 .

[16]  R. Brandis The Limits of Organization , 1975 .

[17]  A. Jaffe,et al.  The Span of the Effect of R&D in the Firm and Industry , 1994 .

[18]  J. S. Long,et al.  Cumulative Advantage and Inequality in Science , 1982 .

[19]  A. Jaffe Real Effects of Academic Research , 1989 .

[20]  B. Klein,et al.  Vertical Integration, Appropriable Rents, and the Competitive Contracting Process , 1978, The Journal of Law and Economics.

[21]  Diana Crane,et al.  Invisible colleges. Diffusion of knowledge in scientific communities , 1972, Medical History.

[22]  M. Brewer,et al.  Collaboration Structure and Information Dilemmas in Biotechnology: Organizational Boundaries as Trust Production , 1994 .

[23]  Z. Griliches HYBRID CORN: AN EXPLORATION IN THE ECONOMIC OF TECHNOLOGICAL CHANGE , 1957 .

[24]  K. Head,et al.  Agglomeration Benefits and Location Choice: Evidence from Japanese Manufacturing Investment in the United States , 1994 .

[25]  G. Taubes Nobel Dreams: Power, Deceit, and the Ultimate Experiment , 1987 .

[26]  H. Demsetz The Theory of the Firm Revisited , 1988 .

[27]  L. Zucker,et al.  Intellectual Capital and the Firm: The Technology of Geographically Localized Knowledge Spillovers , 1994 .

[28]  A. C. Chang,et al.  Construction of biologically functional bacterial plasmids in vitro. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[29]  J. Brittain,et al.  The semiconductor industry. , 1978, Science.

[30]  Who's Who in Economics: a Biographical Dictionary of Major Economists 1700–1981 , 1984 .

[31]  R. Merton Science, Technology and Society in Seventeenth Century England , 1938, Osiris.

[32]  J. Eaton,et al.  International Patenting and Technology Diffusion , 1994 .

[33]  N. Dorfman,et al.  Route 128 : The Development of a Regional High Technology Economy : Research Policy , 1983 .

[34]  Robert G. Eccles,et al.  Doing Deals: Investment Banks at Work. , 1989 .

[35]  Nathan Rosenberg,et al.  Inside the Black Box: Technology and Economics , 1984 .

[36]  David C. Colander,et al.  Research on the Economics Profession , 1989 .

[37]  Rebecca S Eisenberg,et al.  Proprietary rights and the norms of science in biotechnology research. , 1987, The Yale law journal.

[38]  P. Romer Endogenous Technological Change , 1989, Journal of Political Economy.

[39]  James D. Thompson Organizations in Action , 1967 .

[40]  Elhanan Helpman,et al.  North-South R&D Spillovers , 1994, SSRN Electronic Journal.

[41]  Z. Griliches The Search for R&D Spillovers , 1991 .

[42]  Z. Griliches,et al.  Econometric Models for Count Data with an Application to the Patents-R&D Relationship , 1984 .

[43]  Amalya L. Oliver,et al.  Social Networks, Learning, and Flexibility: Sourcing Scientific Knowledge in New Biotechnology Firms , 1994 .

[44]  Robert R. Faulkner,et al.  Short-Term Projects and Emergent Careers: Evidence from Hollywood , 1987, American Journal of Sociology.

[45]  J. Heckman The Common Structure of Statistical Models of Truncation, Sample Selection and Limited Dependent Variables and a Simple Estimator for Such Models , 1976 .

[46]  S. Rosen The Economics of Superstars , 1981 .

[47]  K. Arrow Economic Welfare and the Allocation of Resources for Invention , 1962 .

[48]  Randall W. Eberts,et al.  Universities and the Startup of New Companies: Can We Generalize from Route 128 and Silicon Valley? , 1993 .

[49]  P. Romer Increasing Returns and Long-Run Growth , 1986, Journal of Political Economy.

[50]  George Kozmetsky,et al.  Creating the Technopolis: Linking Technology Commercialization and Economic Development , 1988 .

[51]  R. Nelson The Simple Economics of Basic Scientific Research , 1959, Journal of Political Economy.

[52]  M. Brewer,et al.  Intellectual Capital and the Birth of U.S. Biotechnology Enterprises , 1994 .

[53]  Gavin J. Wright An evolutionary theory of economic change , 1982 .

[54]  Jonathan Eaton,et al.  Trade in Ideas: Patenting and Productivity in the OECD , 1995 .

[55]  G. Grossman,et al.  Innovation and growth in the global economy , 1993 .