Imaging of metabolic activity adaptations to UV stress, drugs and differentiation at cellular resolution in skin and skin equivalents – Implications for oxidative UV damage

[1]  L. Eckhart,et al.  Cell aging and cellular senescence in skin aging — Recent advances in fibroblast and keratinocyte biology , 2019, Experimental Gerontology.

[2]  F. Gruber,et al.  The impact of recent advances in lipidomics and redox lipidomics on dermatological research. , 2019, Free radical biology & medicine.

[3]  A. V. van Kuilenburg,et al.  DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering , 2019, Nature Communications.

[4]  L. Eckhart,et al.  Autophagic Control of Skin Aging , 2019, Front. Cell Dev. Biol..

[5]  S. Ichinose,et al.  Stem cell competition orchestrates skin homeostasis and ageing , 2019, Nature.

[6]  L. Eckhart,et al.  The skin barrier: Epidermis vs environment , 2018, Experimental dermatology.

[7]  K. Drexler,et al.  UVA, metabolism and melanoma: UVA makes melanoma hungry for metastasis , 2018, Experimental dermatology.

[8]  T. Douki,et al.  Energy Metabolism Rewiring Precedes UVB-Induced Primary Skin Tumor Formation. , 2018, Cell reports.

[9]  M. Bergmann,et al.  Exploring Metabolic Configurations of Single Cells within Complex Tissue Microenvironments. , 2017, Cell metabolism.

[10]  K. Dittmann,et al.  Glucose starvation impairs DNA repair in tumour cells selectively by blocking histone acetylation. , 2017, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[11]  L. Eckhart,et al.  Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis , 2017, Scientific Reports.

[12]  C. Menck,et al.  Sunlight damage to cellular DNA: Focus on oxidatively generated lesions. , 2017, Free radical biology & medicine.

[13]  Nicola Zamboni,et al.  An integrative metabolomics and transcriptomics study to identify metabolic alterations in aged skin of humans in vivo , 2017, BMC Genomics.

[14]  J. Ramos-Martínez.  The regulation of the pentose phosphate pathway: Remember Krebs. , 2017, Archives of biochemistry and biophysics.

[15]  Yanping Zhang,et al.  p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway , 2016, Scientific Reports.

[16]  S. Kritchevsky,et al.  Metformin as a Tool to Target Aging. , 2016, Cell metabolism.

[17]  K. Kuratli,et al.  Mitochondrial and glycolytic activity of UV-irradiated human keratinocytes and its stimulation by a Saccharomyces cerevisiae autolysate. , 2016, Journal of photochemistry and photobiology. B, Biology.

[18]  M. Serrano,et al.  G6PD protects from oxidative damage and improves healthspan in mice , 2016, Nature Communications.

[19]  J. Hoeijmakers,et al.  Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis , 2016, Science.

[20]  M. Velarde,et al.  Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype. , 2016, Cell metabolism.

[21]  F. Domann,et al.  Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes , 2016, Archives of Toxicology.

[22]  M. Kastan,et al.  Chromatin perturbations during the DNA damage response in higher eukaryotes. , 2015, DNA repair.

[23]  K. Davies,et al.  Oxidative stress response and Nrf2 signaling in aging. , 2015, Free radical biology & medicine.

[24]  P. Wang,et al.  O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth , 2015, Nature Communications.

[25]  Horst Wenck,et al.  Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells. , 2015, Molecular cell.

[26]  M. Velarde,et al.  Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells , 2015, Proceedings of the National Academy of Sciences.

[27]  Z. Qin,et al.  TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway , 2015, Scientific Reports.

[28]  Joshua D. Rabinowitz,et al.  The return of metabolism: biochemistry and physiology of the pentose phosphate pathway , 2014, Biological reviews of the Cambridge Philosophical Society.

[29]  J. Hayes,et al.  The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. , 2014, Trends in biochemical sciences.

[30]  R. Deberardinis,et al.  Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development , 2013, Science Signaling.

[31]  M. Mildner,et al.  Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model , 2012, Allergy.

[32]  N. Braidy,et al.  Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue , 2012, PloS one.

[33]  B. Viollet,et al.  Role of AMPK in UVB-induced DNA damage repair and growth control , 2012, Oncogene.

[34]  R. Stanton.  Glucose‐6‐phosphate dehydrogenase, NADPH, and cell survival , 2012, IUBMB life.

[35]  Jun-Lae Cho,et al.  Hypoxia inducible factor-1α contributes to UV radiation-induced inflammation, epidermal hyperplasia and immunosuppression in mice , 2012, Photochemical & Photobiological Sciences.

[36]  B. Viollet,et al.  Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage , 2012, Cancer Prevention Research.

[37]  T. Langer,et al.  The Mitochondrial Electron Transport Chain Is Dispensable for Proliferation and Differentiation of Epidermal Progenitor Cells , 2011, Stem cells.

[38]  B. Manning,et al.  Transcriptional control of cellular metabolism by mTOR signaling. , 2011, Cancer research.

[39]  L. Mullenders,et al.  UV-induced photolesions elicit ATR-kinase-dependent signaling in non-cycling cells through nucleotide excision repair-dependent and -independent pathways , 2011, Journal of Cell Science.

[40]  A. Kim,et al.  XPC silencing in normal human keratinocytes triggers metabolic alterations that drive the formation of squamous cell carcinomas. , 2011, The Journal of clinical investigation.

[41]  V. Costanzo,et al.  ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair , 2010, The EMBO journal.

[42]  Qianzheng Zhu,et al.  Hsp27 Protects Adenocarcinoma Cells from UV-Induced Apoptosis by Akt and p21-Dependent Pathways of Survival , 2010, Molecular Cancer Research.

[43]  M. Mildner,et al.  Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model. , 2010, The Journal of investigative dermatology.

[44]  S. Werner,et al.  Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis. , 2010, Genes & development.

[45]  S. Choi,et al.  Reduced mitochondrial properties in putative progenitor/stem cells of human keratinocytes. , 2009, Annals of dermatology.

[46]  B. Berk,et al.  Glucose 6-Phosphate Dehydrogenase Is Regulated Through c-Src–Mediated Tyrosine Phosphorylation in Endothelial Cells , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[47]  R. Moll,et al.  The human keratins: biology and pathology , 2008, Histochemistry and Cell Biology.

[48]  C. Grant,et al.  Metabolic reconfiguration is a regulated response to oxidative stress , 2008, Journal of biology.

[49]  M. Mildner,et al.  Photooxidation Generates Biologically Active Phospholipids That Induce Heme Oxygenase-1 in Skin Cells* , 2007, Journal of Biological Chemistry.

[50]  R. Wiesner,et al.  Human epidermal keratinocytes accumulate superoxide due to low activity of Mn-SOD, leading to mitochondrial functional impairment. , 2007, The Journal of investigative dermatology.

[51]  M. Ziegler,et al.  The power to reduce: pyridine nucleotides--small molecules with a multitude of functions. , 2007, The Biochemical journal.

[52]  H. Gröne,et al.  Integrity and Barrier Function of the Epidermis Critically Depend on Glucosylceramide Synthesis* , 2007, Journal of Biological Chemistry.

[53]  D. Bickers,et al.  Oxidative stress in the pathogenesis of skin disease. , 2006, The Journal of investigative dermatology.

[54]  Eyal Gottlieb,et al.  TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis , 2006, Cell.

[55]  V. Natale,et al.  H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[56]  A. Favier,et al.  Age-dependent DNA repair and cell cycle distribution of human skin fibroblasts in response to UVA irradiation. , 2006, Journal of photochemistry and photobiology. B, Biology.

[57]  R. Ecker,et al.  Microscopy‐based multicolor tissue cytometry at the single‐cell level , 2004, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[58]  N. Bendsøe,et al.  Human epidermal energy metabolism is functionally anaerobic , 2003, Experimental dermatology.

[59]  M. Davies.  Singlet oxygen-mediated damage to proteins and its consequences. , 2003, Biochemical and biophysical research communications.

[60]  C. V. van Noorden,et al.  Post-translational Regulation of Glucose-6-phosphate Dehydrogenase Activity in (Pre)neoplastic Lesions in Rat Liver , 2003, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[61]  E. Tschachler,et al.  Organization and formation of the tight junction system in human epidermis and cultured keratinocytes. , 2002, European journal of cell biology.

[62]  Margaret S. Wu,et al.  Role of AMP-activated protein kinase in mechanism of metformin action. , 2001, The Journal of clinical investigation.

[63]  D. Accili,et al.  Glucose effects on skin keratinocytes: implications for diabetes skin complications. , 2001, Diabetes.

[64]  W. Weninger,et al.  Topically applied lactic acid increases spontaneous secretion of vascular endothelial growth factor by human reconstructed epidermis , 2001, The British journal of dermatology.

[65]  K. Davies,et al.  Mitochondrial free radical generation, oxidative stress, and aging. , 2000, Free radical biology & medicine.

[66]  T. Krieg,et al.  Activation of p70 Ribosomal Protein S6 Kinase Is an Essential Step in the DNA Damage-dependent Signaling Pathway Responsible for the Ultraviolet B-mediated Increase in Interstitial Collagenase (MMP-1) and Stromelysin-1 (MMP-3) Protein Levels in Human Dermal Fibroblasts* , 2000, The Journal of Biological Chemistry.

[67]  M. Totani,et al.  [Glucose-6-phosphate dehydrogenase]. , 1999, Nihon rinsho. Japanese journal of clinical medicine.

[68]  B. Halliwell,et al.  Free radicals in biology and medicine , 1985 .

[69]  I. Mackenzie,et al.  An examination of the relationship between experimentally altered rates of epidermal proliferations and rates of epidermal metabolism assayed in vitro. , 1980, The Journal of investigative dermatology.

[70]  P. Wang,et al.  O-GlcNAcylation of G 6 PD Promotes the Pentose Phosphate Pathway and Tumor Growth , 2017 .

[71]  J. Bouwstra,et al.  Stratum Corneum Lipids: Their Role for the Skin Barrier Function in Healthy Subjects and Atopic Dermatitis Patients. , 2016, Current problems in dermatology.

[72]  S. Kežić,et al.  Filaggrin and Skin Barrier Function. , 2016, Current problems in dermatology.

[73]  L. Eckhart,et al.  Increased sensitivity of histidinemic mice to UVB radiation suggests a crucial role of endogenous urocanic acid in photoprotection. , 2011, The Journal of investigative dermatology.

[74]  K. Wittern,et al.  Aging skin is functionally anaerobic: Importance of coenzyme Q10 for anti aging skin care , 2008, BioFactors.

[75]  L. Packer,et al.  The antioxidant network of the stratum corneum. , 2001, Current problems in dermatology.

[76]  L. Packer,et al.  Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin. , 1994, The Journal of investigative dermatology.

[77]  M. Pathak,et al.  Characterization of superoxide dismutase from mammalian skin epidermis. , 1988, The Journal of investigative dermatology.

[78]  A D Pearse,et al.  Epidermal changes in human skin following irradiation with either UVB or UVA. , 1987, The Journal of investigative dermatology.