Overexpression of ORCA3 and G10H in Catharanthus roseus Plants Regulated Alkaloid Biosynthesis and Metabolism Revealed by NMR-Metabolomics
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Kexuan Tang | Robert Verpoorte | Young Hae Choi | Y. Choi | R. Verpoorte | K. Tang | Qifang Pan | Quan Wang | Fang Yuan | Shihai Xing | Yuesheng Tian | Jingya Zhao | Qi-Fang Pan | Quan Wang | Fang Yuan | Shihai Xing | Jingya Zhao | Yuesheng Tian | Guofeng Wang | Guofeng Wang | Qifang Pan | Jing-ya Zhao | Q. Pan
[1] A. Segre,et al. Nuclear Magnetic Resonance Spectroscopy-Based Metabolite Profiling of Transgenic Tomato Fruit Engineered to Accumulate Spermidine and Spermine Reveals Enhanced Anabolic and Nitrogen-Carbon Interactions1[W][OA] , 2006, Plant Physiology.
[2] Yixiong Tang,et al. Transcriptional response of the catharanthine biosynthesis pathway to methyl jasmonate/nitric oxide elicitation in Catharanthus roseus hairy root culture , 2010, Applied Microbiology and Biotechnology.
[3] H. Noteborn,et al. Chemical fingerprinting for the evaluation of unintended secondary metabolic changes in transgenic food crops. , 2000, Journal of biotechnology.
[4] J. Memelink,et al. Geraniol 10‐hydroxylase1, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis , 2001, FEBS letters.
[5] P. Gantet,et al. The basic helix-loop-helix transcription factor CrMYC2 controls the jasmonate-responsive expression of the ORCA genes that regulate alkaloid biosynthesis in Catharanthus roseus. , 2011, The Plant journal : for cell and molecular biology.
[6] V. De Luca,et al. The Leaf Epidermome of Catharanthus roseus Reveals Its Biochemical Specialization[W][OA] , 2008, The Plant Cell Online.
[7] P. Gantet,et al. Catharanthus roseus G-box binding factors 1 and 2 act as repressors of strictosidine synthase gene expression in cell cultures , 2001, Plant Molecular Biology.
[8] G. Pasquali,et al. Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus , 1998, Planta.
[9] R. Verpoorte,et al. Cell and tissue cultures ofCatharanthus roseus (L.) G. Don: a literature survey , 1989, Plant Cell, Tissue and Organ Culture.
[10] M. Clastre,et al. The iridoid pathway in Catharanthus roseus alkaloid biosynthesis , 2007, Phytochemistry Reviews.
[11] K. San,et al. The expression of 1-deoxy-D-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots. , 2011, Metabolic engineering.
[12] R. Verpoorte,et al. Chapter 3 Biosynthesis of Terpenoid Indole Alkaloids in Catharanthus roseus Cells , 1997 .
[13] T. Kutchan,et al. Alkaloid Biosynthesis[mdash]The Basis for Metabolic Engineering of Medicinal Plants. , 1995, The Plant cell.
[14] Hyung-Kyoon Choi,et al. Metabolic fingerprinting of wild type and transgenic tobacco plants by 1H NMR and multivariate analysis technique. , 2004, Phytochemistry.
[15] K. San,et al. Expression of a feedback‐resistant anthranilate synthase in Catharanthus roseus hairy roots provides evidence for tight regulation of terpenoid indole alkaloid levels , 2004, Biotechnology and bioengineering.
[16] J. Ward,et al. Assessment of 1H NMR spectroscopy and multivariate analysis as a technique for metabolite fingerprinting of Arabidopsis thaliana. , 2003, Phytochemistry.
[17] R. Verpoorte,et al. Cell and tissue cultures of Catharanthus roseus: A literature survey , 1995, Plant Cell, Tissue and Organ Culture.
[18] V. De Luca,et al. Localization of tabersonine 16-hydroxylase and 16-OH tabersonine-16-O-methyltransferase to leaf epidermal cells defines them as a major site of precursor biosynthesis in the vindoline pathway in Catharanthus roseus. , 2005, The Plant journal : for cell and molecular biology.
[19] J. Gills,et al. Stable Vindoline Production in Transformed Cell Cultures of Catharanthus roseus , 1997 .
[20] Y. Chun,et al. Metabolic Discrimination of Catharanthus roseus Calli According to Their Relative Locations Using 1H-NMR and Principal Component Analysis , 2009, Bioscience, biotechnology, and biochemistry.
[21] L. van der Fits,et al. Zinc Finger Proteins Act as Transcriptional Repressors of Alkaloid Biosynthesis Genes in Catharanthus roseus* , 2004, Journal of Biological Chemistry.
[22] K. San,et al. Effect of the Engineered Indole Pathway on Accumulation of Phenolic Compounds in Catharanthus roseus Hairy Roots , 2007, Biotechnology progress.
[23] Jianxin Chen,et al. Expression of deacetylvindoline-4-O-acetyltransferase in Catharanthus roseus hairy roots. , 2007, Phytochemistry.
[24] L. van der Fits,et al. ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism. , 2000, Science.
[25] Saifullah,et al. Metabolic classification of South American Ilex species by NMR-based metabolomics. , 2010, Phytochemistry.
[26] J. Memelink,et al. Biosynthesis of terpenoid indole alkaloids in Catharanthus roseus , 2010 .
[27] R. Verpoorte,et al. Role of vacuolar transporter proteins in plant secondary metabolism: Catharanthus roseus cell culture , 2007, Phytochemistry Reviews.
[28] K. San,et al. Transcriptional response of the terpenoid indole alkaloid pathway to the overexpression of ORCA3 along with jasmonic acid elicitation of Catharanthus roseus hairy roots over time. , 2009, Metabolic engineering.
[29] Maojun Xu,et al. Enhancing terpenoid indole alkaloid production by inducible expression of mammalian Bax in Catharanthus roseus cells , 2007, Science in China Series C: Life Sciences.
[30] Yixiong Tang,et al. Production and metabolic engineering of bioactive substances in plant hairy root culture , 2011, Applied Microbiology and Biotechnology.
[31] Kexuan Tang,et al. Effect of plant growth regulators on the biosynthesis of vinblastine, vindoline and catharanthine in Catharanthus roseus , 2010, Plant Growth Regulation.
[32] Santosh Kumar,et al. Ectopic overexpression of vacuolar and apoplastic Catharanthus roseus peroxidases confers differential tolerance to salt and dehydration stress in transgenic tobacco , 2011, Protoplasma.
[33] K. Tang,et al. Isolation and functional analysis of the Catharanthus roseus deacetylvindoline-4-O-acetyltransferase gene promoter , 2010, Plant Cell Reports.
[34] R. Verpoorte,et al. Strategies for the genetic modification of the medicinal plant Catharanthus roseus (L.) G. Don , 2007, Phytochemistry Reviews.
[35] R. Verpoorte,et al. Catharanthus terpenoid indole alkaloids: biosynthesis and regulation , 2007, Phytochemistry Reviews.
[36] Jean-Marc Nuzillard,et al. NMR metabolomics to revisit the tobacco mosaic virus infection in Nicotiana tabacum leaves. , 2006, Journal of natural products.
[37] V. Burlat,et al. Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-derived primary metabolites. , 2004, The Plant journal : for cell and molecular biology.
[38] R. Verpoorte,et al. Manipulating indole alkaloid production by Catharanthus roseus cell cultures in bioreactors: from biochemical processing to metabolic engineering , 2007, Phytochemistry Reviews.
[39] Santosh Kumar,et al. Overexpression of an apoplastic peroxidase gene CrPrx in transgenic hairy root lines of Catharanthus roseus , 2011, Applied Microbiology and Biotechnology.
[40] L. Qu,et al. Distinguishing transgenic from non-transgenic Arabidopsis plants by (1)H NMR-based metabolic fingerprinting. , 2009, Journal of genetics and genomics = Yi chuan xue bao.
[41] V. Courdavault,et al. Optimization of the transient transformation of Catharanthus roseus cells by particle bombardment and its application to the subcellular localization of hydroxymethylbutenyl 4-diphosphate synthase and geraniol 10-hydroxylase , 2009, Plant Cell Reports.
[42] Robert Verpoorte,et al. Metabolic Discrimination of Catharanthus roseus Leaves Infected by Phytoplasma Using 1H-NMR Spectroscopy and Multivariate Data Analysis1 , 2004, Plant Physiology.
[43] Ling Yuan,et al. Promoter analysis of the Catharanthus roseus geraniol 10-hydroxylase gene involved in terpenoid indole alkaloid biosynthesis. , 2007, Biochimica et biophysica acta.
[44] H. Pearce,et al. The evolution of cancer research and drug discovery at Lilly Research Laboratories. , 2005, Advances in enzyme regulation.
[45] Sarah Oehlschlager,et al. NMR profiling of transgenic peas. , 2004, Plant biotechnology journal.
[46] R. Verpoorte,et al. Phenolic compounds in Catharanthus roseus , 2007, Phytochemistry Reviews.
[47] M. Jolicoeur,et al. Analysis of Catharanthus roseus alkaloids by HPLC , 2007, Phytochemistry Reviews.
[48] Chunzhao Liu,et al. Light-enhanced caffeic acid derivatives biosynthesis in hairy root cultures of Echinacea purpurea , 2007, Plant Cell Reports.
[49] S. Rothstein,et al. Stable and heritable inhibition of the expression of nopaline synthase in tobacco expressing antisense RNA. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[50] R. Verpoorte,et al. Effect of precursor feeding on alkaloid accumulation by a strictosidine synthase over-expressing transgenic cell line S1 of Catharanthus roseus , 2002, Plant Cell, Tissue and Organ Culture.
[51] V. Courdavault,et al. Epidermis is a pivotal site of at least four secondary metabolic pathways in Catharanthus roseus aerial organs , 2006, Planta.
[52] K. Tang,et al. Enhanced accumulation of catharanthine and vindoline in Catharanthus roseus hairy roots by overexpression of transcriptional factor ORCA2 , 2011 .
[53] F. Vázquez-Flota,et al. Multicellular Compartmentation of Catharanthus roseus Alkaloid Biosynthesis Predicts Intercellular Translocation of a Pathway Intermediate , 1999, Plant Cell.
[54] R. Verpoorte,et al. Improved accumulation of ajmalicine and tetrahydroalstonine in Catharanthus cells expressing an ABC transporter. , 2009, Journal of plant physiology.
[55] R. Verpoorte,et al. The Catharanthus alkaloids: pharmacognosy and biotechnology. , 2004, Current medicinal chemistry.
[56] J. Mol,et al. An anti-sense chalcone synthase gene in transgenic plants inhibits flower pigmentation , 1988, Nature.
[57] H. Liu,et al. Overexpression of G10H and ORCA3 in the hairy roots of Catharanthus roseus improves catharanthine production , 2010, Plant Cell Reports.
[58] O. Hoekenga. Using metabolomics to estimate unintended effects in transgenic crop plants: problems, promises, and opportunities. , 2008, Journal of biomolecular techniques : JBT.