Reduction in nicotine intake and oral mucosal changes among users of Swedish oral moist snuff after switching to a low-nicotine product.

The purpose of this investigation was to assess nicotine regulation among users of portion-bag Swedish oral moist snuff (snus) when switching from an ordinary snus product (Brand A) to a low-nicotine product having only half the concentration of nicotine (Brand B). Two studies were performed to compare the short-term effects on consumption and nicotine intake of switching to low-nicotine snus with those of long-term effects. In Study 1, consumption data, soft tissue changes and nicotine intake were measured in a group of 24 habitual users of Swedish portion-bag snus, both during use of their ordinary snus (Brand A) for 2 weeks and during consumption of the low-nicotine product (Brand B) for 10 weeks. In study 2, the same data were measured during 2 weeks in a reference group of 18 snus users who had been habitual users of the low-nicotine snus (Brand B) for at least one year. Although there was no increase in number of hours of daily consumption, the amount of snus consumed increased on average by 2 grams a day (+15%) when switching from Brand A to the low-nicotine Brand B (Study 1). The Brand B reference group (Study 2) consumed about 3 grams less snus a day during the same number of hours as the subjects in Study 1 who had switched to Brand B. These results indicate that snus users compensate to a small extent for the lower nicotine delivery by increasing their consumption on short-term switching but the same does not apply to long-term users.(ABSTRACT TRUNCATED AT 250 WORDS)

[1]  G. Andersson,et al.  Oral mucosal changes and nicotine disposition in users of Swedish smokeless tobacco products: a comparative study. , 1994, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[2]  M. Curvall,et al.  Nicotine and metabolites: analysis and levels in body fluids , 1993 .

[3]  R. Pacifici,et al.  How the steady‐state cotinine concentration in cigarette smokers is directly related to nicotine intake , 1992, Clinical pharmacology and therapeutics.

[4]  G. Englund,et al.  Conjugation Pathways in Nicotine Metabolism , 1991 .

[5]  G. Andersson Snuff-induced changes associated with the use of loose and portion-bag-packed Swedish moist snuff. A clinical, histological and follow-up study. , 1991, Swedish dental journal. Supplement.

[6]  C. Feyerabend,et al.  A rapid gas‐liquid chromatographic method for the determination of cotinine and nicotine in biological fluids , 1990, The Journal of pharmacy and pharmacology.

[7]  J. Wahren,et al.  Simulation and evaluation of nicotine intake during passive smoking: Cotinine measurements in body fluids of nonsmokers given intravenous infusions of nicotine , 1990, Clinical pharmacology and therapeutics.

[8]  T. Axéll,et al.  Clinical picture of snuff dipper's lesion in Swedes. , 1989, Community dentistry and oral epidemiology.

[9]  G. Garrington,et al.  Chondrosarcoma. I. A selected literature review. , 1988, Journal of oral pathology.

[10]  N. Benowitz,et al.  Spontaneous cigarette brand switching: consequences for nicotine and carbon monoxide exposure. , 1987, American journal of public health.

[11]  S. Hecht,et al.  Induction of oral cavity tumors in F344 rats by tobacco-specific nitrosamines and snuff. , 1986, Cancer research.

[12]  N. Benowitz,et al.  Nicotine and carbon monoxide intake from high‐ and low‐yield cigarettes , 1984, Clinical pharmacology and therapeutics.

[13]  M. Curvall,et al.  Simultaneous determination of nicotine and cotinine in plasma using capillary column gas chromatography with nitrogen-sensitive detection. , 1982, Journal of chromatography.

[14]  C. Feyerabend,et al.  Long-term switching to low-tar low-nicotine cigarettes. , 1982, British journal of addiction.

[15]  F. Mehta,et al.  Tobacco‐induced changes in oral leukoplakic epithelium , 1980, Cancer.

[16]  T. Axéll,et al.  The relation of the clinical picture to the histopathology of snuff dipper"s lesions in a Swedish population. , 1976, Journal of oral pathology.