Contrast-enhanced dual mode imaging: photoacoustic imaging plus more

Conventional biomedical imaging modalities in wide clinical use, such as ultrasound imaging, X-ray computed tomography, magnetic resonance imaging, and positron emission tomography, can provide morphological, anatomical, and functional information about biological tissues. However, single mode imaging in conventional medicine provides only limited information for definitive diagnoses. Thus, combinational diagnosis using multiple imaging modalities has become increasingly important. Recently, photoacoustic imaging (PAI) has gained significant attention, and several PAI prototypes have been used in clinical trials. At the same time, PAI has been tested in combination with conventional imaging modalities. For all these imaging modalities, various contrast-enhancing agents have been developed for various purposes. In this review article, we will focus on recent progress in developing dual mode contrast agents for PAI in combination with other conventional imaging modalities.

[1]  R. Dacosta,et al.  Dual in vivo Photoacoustic and Fluorescence Imaging of HER2 Expression in Breast Tumors for Diagnosis, Margin Assessment, and Surgical Guidance , 2015, Molecular imaging.

[2]  Ick Chan Kwon,et al.  Multifunctional nanoparticles for multimodal imaging and theragnosis. , 2012, Chemical Society reviews.

[3]  Jeehyun Kim,et al.  In vivo non-ionizing photoacoustic mapping of sentinel lymph nodes and bladders with ICG-enhanced carbon nanotubes , 2012, Physics in medicine and biology.

[4]  Chulhong Kim,et al.  Sentinel lymph nodes and lymphatic vessels: noninvasive dual-modality in vivo mapping by using indocyanine green in rats--volumetric spectroscopic photoacoustic imaging and planar fluorescence imaging. , 2010, Radiology.

[5]  Jibin Song,et al.  Sequential Drug Release and Enhanced Photothermal and Photoacoustic Effect of Hybrid Reduced Graphene Oxide-Loaded Ultrasmall Gold Nanorod Vesicles for Cancer Therapy. , 2015, ACS nano.

[6]  M. Olivo,et al.  Single Molecule with Dual Function on Nanogold: Biofunctionalized Construct for In Vivo Photoacoustic Imaging and SERS Biosensing , 2015 .

[7]  Zhouyi Guo,et al.  Synergistic effect of chemo-photothermal therapy using PEGylated graphene oxide. , 2011, Biomaterials.

[8]  Todd N. Erpelding,et al.  Performance benchmarks of an array-based hand-held photoacoustic probe adapted from a clinical ultrasound system for non-invasive sentinel lymph node imaging , 2011, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[9]  Huang-Hao Yang,et al.  Co9Se8 Nanoplates as a New Theranostic Platform for Photoacoustic/Magnetic Resonance Dual‐Modal‐Imaging‐Guided Chemo‐Photothermal Combination Therapy , 2015, Advanced materials.

[10]  David W Townsend,et al.  Dual-Modality Imaging: Combining Anatomy and Function* , 2008, Journal of Nuclear Medicine.

[11]  Jesse V Jokerst,et al.  Gold nanorods for ovarian cancer detection with photoacoustic imaging and resection guidance via Raman imaging in living mice. , 2012, ACS nano.

[12]  Orazio Schillaci,et al.  Hybrid SPECT/CT: a new era for SPECT imaging? , 2005, European Journal of Nuclear Medicine and Molecular Imaging.

[13]  Alejandro Garcia-Uribe,et al.  A dual-modality photoacoustic and ultrasound imaging system for noninvasive sentinel lymph node detection: preliminary clinical results , 2014, Photonics West - Biomedical Optics.

[14]  Pengfei Wang,et al.  Red‐Emissive Carbon Dots for Fluorescent, Photoacoustic, and Thermal Theranostics in Living Mice , 2015, Advanced materials.

[15]  Vasilis Ntziachristos,et al.  Shedding light onto live molecular targets , 2003, Nature Medicine.

[16]  Liang Song,et al.  High-speed dynamic 3D photoacoustic imaging of sentinel lymph node in a murine model using an ultrasound array. , 2009, Medical physics.

[17]  Mrinmoy De,et al.  Ligand conjugation of chemically exfoliated MoS2. , 2013, Journal of the American Chemical Society.

[18]  Chulhong Kim,et al.  Porphyrin shell microbubbles with intrinsic ultrasound and photoacoustic properties. , 2012, Journal of the American Chemical Society.

[19]  Gang Zheng,et al.  In situ conversion of porphyrin microbubbles to nanoparticles for multimodality imaging. , 2015, Nature nanotechnology.

[20]  F. Mottaghy,et al.  Clinical value of 18F-fluorodihydroxyphenylalanine positron emission tomography/computed tomography (18F-DOPA PET/CT) for detecting pheochromocytoma , 2010, European Journal of Nuclear Medicine and Molecular Imaging.

[21]  Chulhong Kim,et al.  "Smart" gold nanoparticles for photoacoustic imaging: an imaging contrast agent responsive to the cancer microenvironment and signal amplification via pH-induced aggregation. , 2016, Chemical communications.

[22]  Peter T C So,et al.  High resolution live cell Raman imaging using subcellular organelle-targeting SERS-sensitive gold nanoparticles with highly narrow intra-nanogap. , 2015, Nano letters.

[23]  Xinjian Chen,et al.  Joint segmentation of anatomical and functional images: Applications in quantification of lesions from PET, PET-CT, MRI-PET, and MRI-PET-CT images , 2013, Medical Image Anal..

[24]  M W Vannier,et al.  Craniofacial measurements based on 3D-CT volume rendering: implications for clinical applications. , 2004, Dento maxillo facial radiology.

[25]  Nicole M Dudukovic,et al.  Altered neural substrates of cognitive control in childhood ADHD: evidence from functional magnetic resonance imaging. , 2005, The American journal of psychiatry.

[26]  D. Kobat,et al.  In vivo two-photon microscopy to 1.6-mm depth in mouse cortex. , 2011, Journal of biomedical optics.

[27]  Chulhong Kim,et al.  Organic Nanostructures for Photoacoustic Imaging , 2016 .

[28]  Mitsuharu Miwa,et al.  Fluorescence navigation with indocyanine green for detecting sentinel lymph nodes in breast cancer , 2005, Breast cancer.

[29]  Chulhong Kim,et al.  A Multifunctional Subphthalocyanine Nanosphere for Targeting, Labeling, and Killing of Antibiotic-Resistant Bacteria. , 2015, Angewandte Chemie.

[30]  Mads S. Bergholt,et al.  Development of a multiplexing fingerprint and high wavenumber Raman spectroscopy technique for real-time in vivo tissue Raman measurements at endoscopy , 2013, Journal of biomedical optics.

[31]  Yu-Chung N. Cheng,et al.  Magnetic Resonance Imaging: Physical Principles and Sequence Design , 1999 .

[32]  Hao Wang,et al.  Nano-confined squaraine dye assemblies: new photoacoustic and near-infrared fluorescence dual-modular imaging probes in vivo. , 2014, Bioconjugate chemistry.

[33]  Chulhong Kim,et al.  Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging. , 2010, Journal of biomedical optics.

[34]  Hatem Alkadhi,et al.  Cardiac Image Fusion from Stand-Alone SPECT and CT: Clinical Experience , 2007, Journal of Nuclear Medicine.

[35]  Zengli Liu,et al.  Ultrasound contrast agents and ultrasound molecular imaging. , 2014, Journal of nanoscience and nanotechnology.

[36]  Chulhong Kim,et al.  Acoustic resolution photoacoustic microscopy , 2014, Biomedical Engineering Letters.

[37]  Chulhong Kim,et al.  Biodegradable Photonic Melanoidin for Theranostic Applications. , 2016, ACS nano.

[38]  Gang Liu,et al.  PEGylated WS2 Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual‐Modal CT/Photoacoustic Imaging Guided Photothermal Therapy , 2014, Advanced materials.

[39]  Yu Wang,et al.  Integrated Photoacoustic and Fluorescence Confocal Microscopy , 2010, IEEE Transactions on Biomedical Engineering.

[40]  W. Denk,et al.  Deep tissue two-photon microscopy , 2005, Nature Methods.

[41]  Vasilis Ntziachristos,et al.  Looking and listening to light: the evolution of whole-body photonic imaging , 2005, Nature Biotechnology.

[42]  Hiroshi Ito,et al.  Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps). , 2014, Journal of the American College of Cardiology.

[43]  Marina Faerman,et al.  Comparison of common hard tissue cephalometric measurements between computed tomography 3D reconstruction and conventional 2D cephalometric images. , 2011, The Angle orthodontist.

[44]  Il-Kwon Oh,et al.  Graphene oxide-polyethylenimine nanoconstruct as a gene delivery vector and bioimaging tool. , 2011, Bioconjugate chemistry.

[45]  Xiaolong Liang,et al.  Prussian blue coated gold nanoparticles for simultaneous photoacoustic/CT bimodal imaging and photothermal ablation of cancer. , 2014, Biomaterials.

[46]  Xibo Ma,et al.  Encapsulating tantalum oxide into polypyrrole nanoparticles for X-ray CT/photoacoustic bimodal imaging-guided photothermal ablation of cancer. , 2014, Biomaterials.

[47]  Chengbo Liu,et al.  A facile synthesis of versatile Cu2-xS nanoprobe for enhanced MRI and infrared thermal/photoacoustic multimodal imaging. , 2015, Biomaterials.

[48]  Vasilis Ntziachristos,et al.  Combining microscopy with mesoscopy using optical and optoacoustic label-free modes , 2015, Scientific Reports.

[49]  Snehlata Oberoi,et al.  Three-dimensional assessment of impacted canines and root resorption using cone beam computed tomography. , 2012, Oral surgery, oral medicine, oral pathology and oral radiology.

[50]  Jiang Hsieh,et al.  Computed Tomography: Principles, Design, Artifacts, and Recent Advances, Fourth Edition , 2022 .

[51]  N. Zheng,et al.  Core–Shell Pd@Au Nanoplates as Theranostic Agents for In‐Vivo Photoacoustic Imaging, CT Imaging, and Photothermal Therapy , 2014, Advanced materials.

[52]  Jie Yu,et al.  Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging , 2015, Theranostics.

[53]  Liang Song,et al.  Dual-color photoacoustic lymph node imaging using nanoformulated naphthalocyanines. , 2015, Biomaterials.

[54]  Andrew J Saykin,et al.  Alterations in brain activation during working memory processing associated with breast cancer and treatment: a prospective functional magnetic resonance imaging study. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[55]  Jae Sung Lee,et al.  Predicting Brain Occupancy from Plasma Levels using PET: Superiority of Combining Pharmacokinetics with Pharmacodynamics while Modeling the Relationship , 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[56]  Lihong V. Wang,et al.  In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths. , 2010, Chemical reviews.

[57]  Weibo Cai,et al.  Iron oxide decorated MoS2 nanosheets with double PEGylation for chelator-free radiolabeling and multimodal imaging guided photothermal therapy. , 2015, ACS nano.

[58]  Gerald Antoch,et al.  Comparison of PET, CT, and dual-modality PET/CT imaging for monitoring of imatinib (STI571) therapy in patients with gastrointestinal stromal tumors. , 2004, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[59]  Daniel Razansky,et al.  Multimodal optoacoustic and multiphoton fluorescence microscopy , 2013, Photonics West - Biomedical Optics.

[60]  Manojit Pramanik,et al.  Sentinel lymph nodes in the rat: noninvasive photoacoustic and US imaging with a clinical US system. , 2010, Radiology.

[61]  Weibo Cai,et al.  Positron emission tomography imaging using radiolabeled inorganic nanomaterials. , 2015, Accounts of chemical research.

[62]  Qifa Zhou,et al.  In Vivo Near Infrared Virtual Intraoperative Surgical Photoacoustic Optical Coherence Tomography , 2016, Scientific Reports.

[63]  Chulhong Kim,et al.  Programmable Real-time Clinical Photoacoustic and Ultrasound Imaging System , 2016, Scientific Reports.

[64]  J. Reubi,et al.  N-Terminal Modifications Improve the Receptor Affinity and Pharmacokinetics of Radiolabeled Peptidic Gastrin-Releasing Peptide Receptor Antagonists: Examples of 68Ga- and 64Cu-Labeled Peptides for PET Imaging , 2014, The Journal of Nuclear Medicine.

[65]  S. Gambhir,et al.  Molecular imaging in living subjects: seeing fundamental biological processes in a new light. , 2003, Genes & development.

[66]  M Kortesniemi,et al.  Accuracy of linear measurements using dental cone beam and conventional multislice computed tomography. , 2008, Dento maxillo facial radiology.

[67]  Xin Cai,et al.  Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles. , 2011, ACS nano.

[68]  Chulhong Kim,et al.  Biodegradable Nitrogen-Doped Carbon Nanodots for Non-Invasive Photoacoustic Imaging and Photothermal Therapy , 2016, Theranostics.

[69]  J. Rao,et al.  Fluorescence imaging in vivo: recent advances. , 2007, Current opinion in biotechnology.

[70]  R. Shah,et al.  Introducing Parametric Fusion PET/MRI of Primary Prostate Cancer , 2012, The Journal of Nuclear Medicine.

[71]  Chulhong Kim,et al.  Photoacoustic imaging platforms for multimodal imaging , 2015, Ultrasonography.

[72]  Chulhong Kim,et al.  Methylene blue microbubbles as a model dual-modality contrast agent for ultrasound and activatable photoacoustic imaging , 2014, Journal of biomedical optics.

[73]  Samuel Achilefu,et al.  Multimodal sentinel lymph node mapping with single-photon emission computed tomography (SPECT)/computed tomography (CT) and photoacoustic tomography. , 2012, Translational research : the journal of laboratory and clinical medicine.

[74]  A novel folate-receptor targeted indocyanine green nanoprobe for in vivo photoacoustic/fluorescence dual-modality imaging of breast carcinoma , 2015 .

[75]  Mukund Seshadri,et al.  Non-invasive, Multimodal Functional Imaging of the Intestine with Frozen Micellar Naphthalocyanines , 2014, Nature nanotechnology.

[76]  Chulhong Kim,et al.  In Vivo Photoacoustic and Fluorescence Cystography Using Clinically Relevant Dual Modal Indocyanine Green , 2014, Sensors.

[77]  Chulhong Kim,et al.  Multimodal Photoacoustic Tomography , 2013, IEEE Transactions on Multimedia.

[78]  Wei Wang,et al.  Dual-Modality Noninvasive Mapping of Sentinel Lymph Node by Photoacoustic and Near-Infrared Fluorescent Imaging Using Dye-Loaded Mesoporous Silica Nanoparticles. , 2015, Molecular pharmaceutics.