Survey on evolutionary models of protein-protein interaction network

The research on the evolutionary mechanisms and models of Protein-Protein Interaction(PPI) network is significant for understanding the evolution of the biological systems as well as the formation process of the organisms.So far,there have been kinds of models based on different evolutionary mechanisms.All of these models exhibit certain topological characteristics emerging from the protein-protein interaction networks,while some limitations exist simultaneously.This paper focused on several classic protein-protein interaction network models,analyzing the main ideas of these models and comparing the topological characteristics derived from them with those of real protein-protein interaction networks.A summary of the features for each model was given based on the experiments.At last,several viewpoints for the future research of protein-protein interaction network models were also proposed to provide a useful reference for further studies.